Effects of Ranibizumab and Odix on the Microvascular Structure of the Macular Region

Jian ZHAO; Jiubing XIE; Liankai ZHAO

doi:10.12259/j.issn.2095-610X.S20220930

Volume 43 Issue 9

Sep. 2022

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Jian ZHAO, Jiubing XIE, Liankai ZHAO. Effects of Ranibizumab and Odix on the Microvascular Structure of the Macular Region[J]. Journal of Kunming Medical University, 2022, 43(9): 141-146. doi: 10.12259/j.issn.2095-610X.S20220930

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Jian ZHAO, Jiubing XIE, Liankai ZHAO. Effects of Ranibizumab and Odix on the Microvascular Structure of the Macular Region[J]. Journal of Kunming Medical University, 2022, 43(9): 141-146. doi: 10.12259/j.issn.2095-610X.S20220930

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Effects of Ranibizumab and Odix on the Microvascular Structure of the Macular Region

doi: 10.12259/j.issn.2095-610X.S20220930

1.
Fundus Disease Department of Shenyang Aier Optometry Hospital，Shenyang Liaoning 110003
2.
Tangshan Eye Hospital，Tangshan Hebei 063000
3.
Dept. of Ophthalmology，The 1st Hospital of Dandong，Dandong Liaoning 118000，China

Received Date: 2022-06-27
Available Online: 2022-09-08
Publish Date: 2022-09-29

Abstract

Abstract

Objective To investigate the effect of ranibizumab and odix on the microvascular structure of the macular region in patients with retinal vein occlusion-macular edema （RVO-ME）. Methods All patients with RVO-ME admitted and diagnosed in the ophthalmology department of our hospital were included in the screening scope, and 101 of them were selected as the research subjects. The inclusion time was from January 2020 to December 2021, and they were divided into the observation group and the control group according to the differences in treatment methods, with 51 cases and 50 cases in each group. The observation group was given intravitreal injection of ranibizumab, and the control group was given intravitreal injection of AODEX. The age, gender, best corrected visual acuity （BCVA）, macular fovea thickness （CMT）, shallow retinal capillary layer （SCP）, deep capillary layer blood flow density （DCP） and other effective rates of the two groups before and after the treatment were included in spss21.0 software to compare the treatment differences. Results （1） There was no significant difference in BCVA, CMT, SCP, and DCP between the two groups before the treatment （P > 0.05）. With the delay of treatment time, BCVA, CMT, SCP and DCP of the two groups were significantly improved ,the control group was better than the observation group and the difference was statistically significant （P < 0.05） and （2） The total effective rates of the observation group were 94.12% and 98.04% at 3 and 6 months after the treatment while the total effective rates of the control group were 84.00% and 88.00%, showing that the control group was better than the observation group and the difference was statistically significant （P < 0.05）. Conclusion Autodix treatment can effectively improve the macular microvascular structure in RVO-ME patients.
- Ranibizumab,
- AODIX,
- Retinal vein occlusion,
- Macular edema,
- Microvascular structure of macular region

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References(16)

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