Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population

Yanfen MA; Jian HU; Depei CAI; Yongfeng QIAO; Xiaoqin WANG

doi:10.12259/j.issn.2095-610X.S20221001

Volume 43 Issue 10

Oct. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(10): 115-121

Yanfen MA, Jian HU, Depei CAI, Yongfeng QIAO, Xiaoqin WANG. Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population[J]. Journal of Kunming Medical University, 2022, 43(10): 115-121. doi: 10.12259/j.issn.2095-610X.S20221001

Citation:

Yanfen MA, Jian HU, Depei CAI, Yongfeng QIAO, Xiaoqin WANG. Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population[J]. Journal of Kunming Medical University, 2022, 43(10): 115-121. doi: 10.12259/j.issn.2095-610X.S20221001

Citation:

Yanfen MA, Jian HU, Depei CAI, Yongfeng QIAO, Xiaoqin WANG. Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population[J]. Journal of Kunming Medical University, 2022, 43(10): 115-121. doi: 10.12259/j.issn.2095-610X.S20221001

PDF( 1329 KB)

Correlation between Serum Gamma-glutamyl Transferase Level and Blood Lipid Indexes in 3137 Checkup Population

doi: 10.12259/j.issn.2095-610X.S20221001

1.
Dept. of Clinical Laboratory，The 1st Affiliated Hospital of Xi’an Jiaotong University，Xi’an Shaanxi 710061
2.
Dept. of Clinical Laboratory，Xi’an Aerospace General Hospital，Xi’an Shaanxi 710199
3.
Dept. of Clinical Laboratory，Hanzhong Central Hospital， Hanzhong Shaanxi 723099，China

Received Date: 2022-05-07
Available Online: 2022-06-25
Publish Date: 2022-10-31

Abstract

Abstract

Objectives To explore the relationship between the increase of Gamma-glutamyl transferase （GGT） and dyslipidemia in checkup population. Methods 3137 subjects were selected from April 2020 to August 2021. The baseline data, GGT, and four serum lipid indexes of total cholesterol （TC）, triglyceride （TG）, high lipoprotein （HDL） and low density lipoprotein （LDL） were collected. First of all, according to the quartile of GGT concentration, the levels of the four indexes of blood lipids were compared; secondly, the correlation between the concentration of GGT and the four indexes of blood lipids was analyzed; again, the differences of GGT levels among different groups of dyslipidemia were compared; finally, the risk factors affecting the increase of GGT were screened out by binary Logistic regression analysis. Results With the increase of GGT concentration, the abnormal rate and abnormal level of TC, TG and LDL increased significantly, and the abnormal rate of HDL increased and the abnormal level decreased significantly, and the differences were statistically significant （all P < 0.05）; Spearman correlation analysis showed that GGT was positively correlated with TC, TG and LDL （r = 0.200, 0.395, 0.186, all P < 0.05）, and negatively correlated with HDL （r = -0.144, P < 0.05）; The concentration of GGT increased with the increase of abnormal indexes in the four indexes （all P < 0.05）; The multivariate analysis of binary Logistic regression showed that TG was an independent risk factor for the increase of GGT concentration, regardless of the median or reference value of GGT positive, and the OR values were 2.360 （95%CI: 2.068～2.695） and 1.635 （95%CI: 1.481～1.805）, respectively. Conclusions The increase of GGT can be caused by the disorder of blood lipid metabolism, and the degree of increase is closely related to the severity of dyslipidemia. Persistent elevated GGT associated with dyslipidemia may be helpful in the diagnosis and treatment of dyslipidemia-related diseases.
- Gamma-glutamyl transferase,
- Physical examination,
- Triglyceride,
- Dyslipidemia,
- Correlation

FullText(HTML)

References(18)

References

[1]	Yang J D,Hainaut P,Gores G J,et al. A global view of hepatocellular carcinoma:trends,risk,prevention and management[J]. Nat Rev Gastroenterol Hepatol,2019,16(10):589-604. doi: 10.1038/s41575-019-0186-y
[2]	Choi E J,Lee S Y. Index of cardiac age index and cardiometabolic biomarkers in adults with metabolic syndrome[J]. Metab Syndr Relat Disord,2021,19(5):288-295. doi: 10.1089/met.2020.0095
[3]	Neuman M G,Malnick S,Chertin L. Gamma glutamyl transferase - an underestimated marker for cardiovascular disease and the metabolic syndrome[J]. J Pharm Pharm Sci,2020,23(1):65-74. doi: 10.18433/jpps30923
[4]	Cruz M A,Cruz J F,Macena L B,et al. Association of the nonalcoholic hepatic steatosis and its degrees with the values of liver enzymes and homeostasis model assessment-insulin resistance index[J]. Gastroenterology Res,2015,8(5):260-264. doi: 10.14740/gr685w
[5]	Lee J H,Lee H S,Lee Y J. Serum gamma-glutamyltransferase as an independent predictor for incident type 2 diabetes in middle-aged and older adults:Findings from the KoGES over 12 years of follow-up[J]. Nutr Metab Cardiovasc Dis,2020,30(9):1484-1491. doi: 10.1016/j.numecd.2020.04.027
[6]	Hong N,Lee E Y,Kim C O. Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults:Results from the fifth Korea national health and nutrition examination survey,2010-2011[J]. Endocr J,2015,62(7):585-592. doi: 10.1507/endocrj.EJ15-0119
[7]	Ryoo J H,Oh C M,Kim H S,et al. Clinical association between serum gamma-glutamyltransferase levels and the development of insulin resistance in Korean men:a 5-year follow-up study[J]. Diabet Med,2014,31(4):455-461. doi: 10.1111/dme.12315
[8]	Rytz C L,Pialoux V,Mura M,et al. Impact of aerobic exercise,sex,and metabolic syndrome on markers of oxidative stress:results from the brain in motion study[J]. J Appl Physiol (1985),2020,128(4):748-756.
[9]	Panchal S K,Poudyal H,Iyer A,et al. High-carbohydrate,high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats[J]. J Cardiovasc Pharmacol,2011,57(5):611-624.
[10]	Feng G,Feng L,Zhao Y. Association between ratio of gamma-glutamyl transpeptidase to high-density lipoprotein cholesterol and prevalence of nonalcoholic fatty liver disease and metabolic syndrome:a cross-sectional study[J]. Ann Transl Med,2020,8(10):634. doi: 10.21037/atm-19-4516
[11]	Defilippis A P,Blaha M J,Martin S S,et al. Nonalcoholic fatty liver disease and serum lipoproteins:the multi-ethnic study of atherosclerosis[J]. Atherosclerosis,2013,227(2):429-436. doi: 10.1016/j.atherosclerosis.2013.01.022
[12]	Barbalho S M,Tofano R J,de Oliveira M B,et al. HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters[J]. J Vasc Bras,2019,18(1):e20180109.
[13]	Dowla S,Aslibekyan S,Goss A,et al. Dyslipidemia is associated with pediatric nonalcoholic fatty liver disease[J]. J Clin Lipidol,2018,12(4):981-987. doi: 10.1016/j.jacl.2018.03.089
[14]	Jakobsdottir S,van Nieuwpoort I C,van Bunderen C C,et al. Acute and short-term effects of caloric restriction on metabolic profile and brain activation in obese,postmenopausal women[J]. Int J Obes (Lond),2016,40(11):1671-1678. doi: 10.1038/ijo.2016.103
[15]	Wu K T,Kuo P L,Su S B,et al. Nonalcoholic fatty liver disease severity is associated with the ratios of total cholesterol and triglycerides to high-density lipoprotein cholesterol[J]. J Clin Lipidol,2016,10(2):420-425. doi: 10.1016/j.jacl.2015.12.026
[16]	Kaneko K,Yatsuya H,Li Y,et al. Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men:12-year follow up[J]. J Diabetes Investige,2019,10(3):837-845. doi: 10.1111/jdi.12930
[17]	Fang Y L,Chen H,Wang C L,et al. Pathogenesis of non-alcoholic fatty liver disease in children and adolescence:from "two hit theory" to "multiple hit model"[J]. World J Gastroenterol,2018,24(27):2974-2983. doi: 10.3748/wjg.v24.i27.2974
[18]	Marra F,Svegliati-Baroni G. Lipotoxicity and the gut-liver axis in NASH pathogenesis[J]. J Hepatol,2018,68(2):280-295. doi: 10.1016/j.jhep.2017.11.014

Relative Articles(20)

Relative Articles

[1]	Yuyun YOU, Yunfei HONG, Xia ZHENG, Feifei LIU, Jinsong YIN. The Association between Serum Homocysteine to High-Density Lipoprotein Cholesterol Ratio and Premature Coronary Heart Disease. Journal of Kunming Medical University, 2025, 46(4): 1-7.
[2]	Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population. Journal of Kunming Medical University, 2024, 45(5): 8-15. doi: 10.12259/j.issn.2095-610X.S20240502
[3]	Yanfen MA, Sasa LIU, Jian HU, Depei CAI, Yongfeng QIAO, Xiaoqin WANG. Analysis of the Predictive Effects of Lipid Metabolism and Liver Function Indicators on Prediabetes. Journal of Kunming Medical University, 2024, 46(): 1-7.
[4]	Yan DONG, Wenwen LI, Wenlong CUI, Jie LIU, Weihong BI. Correlation Analysis of Chronic Diseases and Physical Labor Intensity among the Rural Elderly in Two Counties of Yunnan Province. Journal of Kunming Medical University, 2023, 44(3): 68-73. doi: 10.12259/j.issn.2095-610X.S20230303
[5]	Yan LIANG, Lei WANG, Ming LEI, Benchao CHEN, Ping SUN, Shuai LI, Li LIU, Qianrong WANG, Manlin LIAO, Qianli MA. Correlation between KRAS Gene Polymorphism and Non-small Cell Lung Cancer in Yunnan Han Population. Journal of Kunming Medical University, 2023, 44(2): 52-60. doi: 10.12259/j.issn.2095-610X.S20230210
[6]	Jianheng AO, Lei MIAO, Huiying WANG, Tianyun ZHANG, Tao WANG, Yonghang TANG, Liping HU, Shengjie NIE. Correlation between DNA Detection Rate and Sweat Pore Density of Palm Touch Biological Samples. Journal of Kunming Medical University, 2023, 44(6): 136-142. doi: 10.12259/j.issn.2095-610X.S20230601
[7]	Xiaohua LU, Hongxin YUAN. The Analysis of the Correlation between BTLA，CTLA-4 Gene Polymorphisms and the Efficacy and Prognosis of TACE Combined Targeted Therapy for Liver Cancer. Journal of Kunming Medical University, 2023, 44(9): 126-135. doi: 10.12259/j.issn.2095-610X.S20230927
[8]	Jingshan CHEN, Li LI, Shili SHANG, Guoyong HE, Wenjing ZHOU, Sha LI, Di ZHANG, Yonglan LIU, Jun LI. Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia. Journal of Kunming Medical University, 2023, 44(1): 47-53. doi: 10.12259/j.issn.2095-610X.S20230111
[9]	Rong LIU, Yang SUN, Fameng LUO, Dezhi TAO, Haiyan ZHANG. Correlation between the Acceptance of Illness and Quality of Life in Patients with Inflammatory Bowel Disease. Journal of Kunming Medical University, 2022, 43(5): 173-178. doi: 10.12259/j.issn.2095-610X.S20220507
[10]	Jia YANG, Ya-xian LI, Ying-ying WANG, Lin XIAO, Chuan-yin LI, Fang TAN, Qian-li MA, Shu-yuan LIU. Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province. Journal of Kunming Medical University, 2021, 42(10): 22-28. doi: 10.12259/j.issn.2095-610X.S20211037
[11]	Pu-mei CUI, Tai-fang CHEN, Chao CHEN, Yong-mei LIANG, Yue XU. Correlation Analysis of Antimicrobial Use and Common Bacterial Resistance in a Hospital in Yunnan From 2016 to 2019. Journal of Kunming Medical University, 2021, 42(11): 140-147. doi: 10.12259/j.issn.2095-610X.S20211127
[12]	Xin WU, Yun LI, Pin-fei ZOU, Mei-ling LI, Yong-bin PU. The Detection Rate of Musculoskeletal Ultrasound in Patients with Rheumatic Knee Arthritis and Its Correlation with Knee Function. Journal of Kunming Medical University, 2021, 42(8): 78-82. doi: 10.12259/j.issn.2095-610X.S20210814
[13]	Ying HUANG, Xiang LI, Shan JIANG, Bing LIU, Yan-ling ZHANG, Yang LI, Hua HE, Yan WU, Yun LUO, Jun XU. Correlation Analysis of Chest Imaging and Laboratory Indicators in Patients with 2019-nCoV Infection. Journal of Kunming Medical University, 2021, 42(12): 129-134. doi: 10.12259/j.issn.2095-610X.S20211232
[14]	Li-jia ZHU, Xiao-dan MA, Jiang DUAN, Meng LI, Yong-kun HUANG. Difference Analysis of First Liver Function Indexes of Newborns with Different Gestational Age and Birth Weight. Journal of Kunming Medical University, 2021, 42(3): 121-126. doi: 10.12259/j.issn.2095-610X.S20210330
[15]	Juan-juan WANG, Yu-qing CHEN, Qian DENG, Jian GAO. The Correlation between Myocardial Enzymes and the Severity of Ketoacidosis in Children with Type 1 Diabetes. Journal of Kunming Medical University, 2021, 42(1): 147-151. doi: 10.12259/j.issn.2095-610X.S20210129
[16]	Chang Wei , Zhang Xue Hui , Wang Yang , Wang Qi , Wang Song Mei , Xu Fang . The Correlation Analysis between Hyperuricemia and Dyslipidemia in Rural Areas, Yunnan Province. Journal of Kunming Medical University, 2018, 39(06): 124-127.
[17]	Zhang Hong . . Journal of Kunming Medical University,
[18]	Mei Xue . . Journal of Kunming Medical University,
[19]	Zhao Jin You . . Journal of Kunming Medical University,
[20]	Zheng Hong Mei . . Journal of Kunming Medical University,