Effects of Perindopril on Intestinal Microecology in Obese Rats

Yandong GUO; Rudan HONG; Yanjiao WANG; Teng ZHANG; Yuemei FENG; Nishang ZHANG; Ying QIAN; Zaogai YANG; Fei MI; Jianzhong YIN

doi:10.12259/j.issn.2095-610X.S20221101

Volume 43 Issue 11

Nov. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(11): 9-16

Yandong GUO, Rudan HONG, Yanjiao WANG, Teng ZHANG, Yuemei FENG, Nishang ZHANG, Ying QIAN, Zaogai YANG, Fei MI, Jianzhong YIN. Effects of Perindopril on Intestinal Microecology in Obese Rats[J]. Journal of Kunming Medical University, 2022, 43(11): 9-16. doi: 10.12259/j.issn.2095-610X.S20221101

Citation:

Yandong GUO, Rudan HONG, Yanjiao WANG, Teng ZHANG, Yuemei FENG, Nishang ZHANG, Ying QIAN, Zaogai YANG, Fei MI, Jianzhong YIN. Effects of Perindopril on Intestinal Microecology in Obese Rats[J]. Journal of Kunming Medical University, 2022, 43(11): 9-16. doi: 10.12259/j.issn.2095-610X.S20221101

Citation:

Yandong GUO, Rudan HONG, Yanjiao WANG, Teng ZHANG, Yuemei FENG, Nishang ZHANG, Ying QIAN, Zaogai YANG, Fei MI, Jianzhong YIN. Effects of Perindopril on Intestinal Microecology in Obese Rats[J]. Journal of Kunming Medical University, 2022, 43(11): 9-16. doi: 10.12259/j.issn.2095-610X.S20221101

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Effects of Perindopril on Intestinal Microecology in Obese Rats

doi: 10.12259/j.issn.2095-610X.S20221101

1.
Basic Medical College of Baoshan College of Traditional Chinese Medicine，Baoshan Yunnan 678000
2.
School of Public Health，Kunming Medical University， Kunming Yunnan 650500，China

Received Date: 2022-03-28
Publish Date: 2022-11-25

Abstract

Abstract

Objective To study the effect of perindopril on body weight, blood lipids and intestinal flora of obese rats. Methods SPF Wistar rats were randomly divided into normal group, model group, perindopril low-dose and high-dose groups （0.4, 2 mg/（kg·d））. Changes in LDL-C, HDL-C, UA, GLU and intestinal flora in feces were compared. Results Compared with the normal group, the final body weight, body weight gain and Lee's index of the rats in the model group increased （P < 0.01）, indicating that the model was successfully established; compared with the model group, the body weight of the rats in the perindopril low and high dose groups significantly decreased （ P < 0.05, 0.01）. The results of 16S rRNA sequencing showed that perindopril could improve the level of intestinal flora diversity in rats, and the total number of OTUs in the perindopril low-dose group increased by 4.56%; at the phylum and genus levels, the perindopril low-dose group The species composition of Firmicutes was significantly decreased （P < 0.01）, and the species composition of Alloprevotella, NK4A214_group, no_rank_f__Erysipelotrichaceae, norank_f__Eubacterium_coprostanoligenes_group were significantly increased （P < 0.05, 0.01）, and The species compositions of Actinobacteriota, norank_f__Erysipelotrichaceae, Enterorhabdus and Staphylococcus were significantly increased in the perindopril high-dose group （P < 0.01）. Conclusion Perindopril can reduce the body weight of obese rats, and its effect may be related to the regulation of intestinal flora composition of rats.
- Perindopril,
- Obesity,
- Rats,
- Intestinal microecology

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References(24)

References

[1]	Bl ü her M. Obesity:global epidemiology and pathogenesis[J]. Nat Rev Endocrino,2019,15(5):288-298. doi: 10.1038/s41574-019-0176-8
[2]	World Health Organization. Obesity and overweight[EB/OL]. （2021-06-09）[2022-12-10]. https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight.
[3]	Zhang X,Zhang M,Zhao Z P,et al. Geographic variation in prevalence of adult obesity in China:Results from the 2013-2014 national chronic disease and risk factor surveillance[J]. Ann Intern Med,2019,172(4):291-293.
[4]	Wang Y,Zhao L,Gao L,et al. Health policy and public health implications of obesity in China[J]. Lancet Diabetes Endocrinol,2021,9(7):446-461.
[5]	Gasmi A,Mujawdiya P K,Pivina L,et al. Relationship between gut microbiota,gut hyperpermeability,and obesity[J]. Curr Med Chem,2020,28(28):827-839.
[6]	Canfora E E,Meex R C R,Venema K,et al. Gut microbial metabolites in obesity,NAFLD and T2DM[J]. Nature Reviews Endocrinology,2019,15(5):261-273. doi: 10.1038/s41574-019-0156-z
[7]	Li R,Huang X,Liang X,et al. Integrated omics analysis reveals the alteration of gut microbe -metabolites in obese adults[J]. Briefings in Bioinformatics,2020,22(3):1-16.
[8]	Kootte R S, Levin E, Salojarvi J, et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition[J]. Cell Metabolism, 2017, 26（4）: 611-619.
[9]	郭艳东. 云南高原偏寒地区汉族PPARγ2基因Pro12Ala、C161-T多态性与肥胖的关联研究[D]. 昆明: 昆明医科大学, 2020.
[10]	Jones B H,Standridgr M K,Moustaid N. Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells[J]. Endocrinolog,1997,138(4):1512-1519. doi: 10.1210/endo.138.4.5038
[11]	Barton M, Carmona R, Morawietz H. Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: Evidence for a regulatory role of endothelin[J]. Hypertension, 2000, 35（1）: 329-336.
[12]	Rankinen T,Zuberi A,Chagnon Y C,et al. The human obesity gene map:The 2005 update[J]. Obesity,2006,14(4):529-644. doi: 10.1038/oby.2006.71
[13]	Masuo K,Mikami H,Ogihara T,et al. Weight reduction and pharmacologic treatment in obese hypertensives[J]. Am J Hypertens,2001,14(6):530-538. doi: 10.1016/S0895-7061(00)01279-6
[14]	Scholze J,Grimm E,Herrmann D,et al. Optimal treatment of obesity-related hypertension:the Hypertension-Obesity-Sibutramine (HOS) study[J]. Circulation,2007,115(15):1991-1998. doi: 10.1161/CIRCULATIONAHA.106.625400
[15]	吐克孜. 吾守尔,王茹,张姣姣,等. 樱桃李果实提取物对小鼠高脂膳食诱导肥胖的预防作用[J]. 中国食品学报,2021,21(6):144-149.
[16]	Katta N,Loethen T,Lavie C J,et al. Obesity and coronary heart disease:Epidemiology,pathology,and coronary artery imaging[J]. Current Problems in Cardiology,2020,46(3):1-43.
[17]	Ussar S,Griffin N W,Bezy O,et al. Interactions between gut microbiota,host genetics and diet modulate the predisposition to oObesity and metabolic syndrome[J]. Cell Metabolism,2015,22(3):516-530. doi: 10.1016/j.cmet.2015.07.007
[18]	叶晓琳,马亚楠,刘洋,等. 肠道菌群在肥胖发病中的作用[J]. 中国微生态学杂志,2020,32(11):1349-1353.
[19]	Chakraborti C K. New-found link between microbiota and obesity[J]. World J Gastrointest Pathophysiol,2015,6(4):110-119. doi: 10.4291/wjgp.v6.i4.110
[20]	Jumpertz R,Le D S,Turnbaugh P J,et al. Energy-balance studies reveal associations between gut microbes,caloric load,and nutrient ab- sorption in humans[J]. Am J Clin Nutr,2011,94(1):58-65. doi: 10.3945/ajcn.110.010132
[21]	Da Silva C C,Monteil M A,Davis E M. Overweight and obesity in chil- dren are associated with an abundance of firmicutes and reduction of Bifidobacterium in their gastrointestinal microbiota[J]. Child Obes,2020,16(3):204-210. doi: 10.1089/chi.2019.0280
[22]	Ivarsson E,Roos S,Liu H Y,et al. Fermentable non-starch polysaccharides increases the abundance of Bacteroides-PrevotellaPorphyromonas in ileal microbial community of growing pigs[J]. Animal,2014,8(11):1777-1787. doi: 10.1017/S1751731114001827
[23]	Chambers E S,Viardot A,Psichas A,et al. Effects of targeted delivery of propionate to the human colon on appetite regulation,body weight maintenance and adiposity in overweight adults[J]. Gut,2015,64(11):1-10.
[24]	Murugesan S,Nirmalkar K,Hoyovadillo C,et al. Gut microbiome production of short-chain fatty acids and obesity in children[J]. Eur J Clin Microbiol Infect Dis,2018,37(4):1-5.

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