Efficacy and Safety of rhTPO Combined with High-dose Short-cycle Dexamethasone Regimen in Treatment of ANa-positive Adult Immune Thrombocytopenia

Yanling JIN; Jianmei LI

doi:10.12259/j.issn.2095-610X.S20221119

Volume 43 Issue 11

Nov. 2022

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Yanling JIN, Jianmei LI. Efficacy and Safety of rhTPO Combined with High-dose Short-cycle Dexamethasone Regimen in Treatment of ANa-positive Adult Immune Thrombocytopenia[J]. Journal of Kunming Medical University, 2022, 43(11): 146-150. doi: 10.12259/j.issn.2095-610X.S20221119

Citation:

Yanling JIN, Jianmei LI. Efficacy and Safety of rhTPO Combined with High-dose Short-cycle Dexamethasone Regimen in Treatment of ANa-positive Adult Immune Thrombocytopenia[J]. Journal of Kunming Medical University, 2022, 43(11): 146-150. doi: 10.12259/j.issn.2095-610X.S20221119

Citation:

Yanling JIN, Jianmei LI. Efficacy and Safety of rhTPO Combined with High-dose Short-cycle Dexamethasone Regimen in Treatment of ANa-positive Adult Immune Thrombocytopenia[J]. Journal of Kunming Medical University, 2022, 43(11): 146-150. doi: 10.12259/j.issn.2095-610X.S20221119

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Efficacy and Safety of rhTPO Combined with High-dose Short-cycle Dexamethasone Regimen in Treatment of ANa-positive Adult Immune Thrombocytopenia

doi: 10.12259/j.issn.2095-610X.S20221119

Yanling JIN,
Jianmei LI^,

Dept. of Hematology，The First People’s Hospital of Qujing，Qujing Yunnan 655099，China

Received Date: 2022-04-22
Available Online: 2022-10-28
Publish Date: 2022-11-14

Abstract

Abstract

Objective To investigate the combination of recombinant human thrombopoietin （rhTPO） combined with high-dose short-cycle dexamethasone （hexadecadrol, HDD） regimen in the treatment of anti-nuclear antibody （ANA） positive adults with immune thrombocytopenia （immune thrombocytopenia, ITP） efficacy and safety. Methods A total of 66 adult patients with ANA-positive immune thrombocytopenia diagnosed in Qujing First People's Hospital from August 2020 to December 2021 were selected and divided into HDD alone group （n = 22）, rhTPO alone group （n = 22） and combination group （n = 22） by random number table method. The HDD alone group was treated with high-dose short-cycle dexamethasone （HDD）, the rhTPO alone group was treated with rhTPO, and the combination group was treated with HDD and rhTPO. The liver and kidney-related indexes, platelet count, clinical efficacy including total effective rate, recurrence rate, time to effective standard of platelet count and adverse reactions were compared between the three groups before and after treatment. Results The total effective rate of the combination group was significantly higher than that of HDD alone group and rhTPO alone group （P < 0.05）. The platelet count of combination group was higher than that of HDD alone group and rhTPO alone group, and the effective time of platelet count was shorter than that of HDD alone group and rhTPO alone group （P < 0.05）. There was no significant difference in platelet transfusion rate among the three groups （P > 0.05）. There was no significant difference in the incidence of total adverse reactions among the three groups （P > 0.05）. There were no significant differences in ALT, AST, BUM and Scr levels among the three groups before and after treatment （P > 0.05）. Compared with before treatment, there were no significant differences in ALT, AST, BUM and Scr levels among the three groups after treatment （P > 0.05）. After the course of treatment, there was no significant difference in the recurrence rate among the three groups （P > 0.05）. Conclusion The use of rhTPO combined with high-dose short-cycle HDD therapy can significantly improve the clinical efficacy of ANA-positive adult ITP, increase the number of platelets, and has good safety.
- Thrombopoietin,
- Dexamethasone,
- Immune thrombocytopenia,
- Antinuclear antibodies

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