Effect of Early Interventional Therapy with Bronchoscopic Alveolar Lavage on AIDS Patients Complicated with Severe Pneumonia

Le ZHANG; Yuanqiang HE; Jiawei XIA; Shu LIU; Bin BAI; Xing LIU

doi:10.12259/j.issn.2095-610X.S20221120

Volume 43 Issue 11

Nov. 2022

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Le ZHANG, Yuanqiang HE, Jiawei XIA, Shu LIU, Bin BAI, Xing LIU. Effect of Early Interventional Therapy with Bronchoscopic Alveolar Lavage on AIDS Patients Complicated with Severe Pneumonia[J]. Journal of Kunming Medical University, 2022, 43(11): 151-155. doi: 10.12259/j.issn.2095-610X.S20221120

Citation:

Le ZHANG, Yuanqiang HE, Jiawei XIA, Shu LIU, Bin BAI, Xing LIU. Effect of Early Interventional Therapy with Bronchoscopic Alveolar Lavage on AIDS Patients Complicated with Severe Pneumonia[J]. Journal of Kunming Medical University, 2022, 43(11): 151-155. doi: 10.12259/j.issn.2095-610X.S20221120

Citation:

Le ZHANG, Yuanqiang HE, Jiawei XIA, Shu LIU, Bin BAI, Xing LIU. Effect of Early Interventional Therapy with Bronchoscopic Alveolar Lavage on AIDS Patients Complicated with Severe Pneumonia[J]. Journal of Kunming Medical University, 2022, 43(11): 151-155. doi: 10.12259/j.issn.2095-610X.S20221120

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Effect of Early Interventional Therapy with Bronchoscopic Alveolar Lavage on AIDS Patients Complicated with Severe Pneumonia

doi: 10.12259/j.issn.2095-610X.S20221120

Le ZHANG^{1, 2},
Yuanqiang HE^{2, 3},
Jiawei XIA^{1, 2},
Shu LIU^{1, 2},
Bin BAI^{1, 2},
Xing LIU^{2, 4
,
,}

1.
Dept. of Intensive Care Unit，The Third People’s Hospital of Kunming，Kunming Yunnan 650041
2.
Clinical Medical Centre for Infectious Diseases in Yunnan Province，Kunming Yunnan 650041
3.
Dept. of Cardiology
4.
Dept. of Pharmacy，The Third People’s Hospital of Kunming， Kunming Yunnan 650041，China

Received Date: 2022-08-14
Available Online: 2022-10-28
Publish Date: 2022-11-14

Abstract

Abstract

Objective To explore the effect of early interventional therapy with bronchoscopic alveolar lavage on AIDS patients complicated with severe pneumonia. Methods Adult AIDS patients complicated with severe pneumonia （44 cases） who were hospitalized in the Department of Intensive Care Unit of the Third People’s Hospital of Kunming from January 2018 to June 2021 and needed invasive mechanical ventilation support were selected. They were divided into observation group and control group , with 22 cases in each group. The observation group was treated with bronchoscopic alveolar lavage on the basis of conventional treatment, the control group received conventional treatment. We compared the efficacy of the two groups before and after treatment such as infectivity index, arterial oxygen saturation, arterial oxygen partial pressure and oxygenation index, APACHE II, hospitalization days in the intensive care unit, 28-day mortality, mechanical ventilation time and the time of body temperature returns to normal. Results （1）After one-week treatment, the procalcitonin and c-reactive protein levels in the observation group were significantly lower than those in the control group （P < 0.05）. （2）The levels of SaO₂, PaO₂, PaO₂/FiO₂ in the observation group were higher than those in the control group after one-week treatment, the difference was statistically significant （P < 0.05）. （3）After one-week treatment, the score of APACHE II in the observation group is decrease than the control group, the difference was statistically significant （P < 0.05）. In the observation group, the data about mechanical ventilation time and the time of body temperature returns to normal all lower than those in the control group, the difference was statistically significant （P < 0.05）. The 28-day mortality of the observation group was significantly lower than that of the control group, but the difference was not statistically significant （P > 0.05）. There was no statistically significant difference in Hospitalization days between the two groups （P > 0.05）. Conclusions Early interventional therapy with bronchoscopic alveolar lavage can effectively reduce the infection index, reduce the inflammatory reaction of the body, improve oxygenation, and reduce the time of invasive mechanical ventilation in the treatment of AIDS patients complicated with severe pneumonia. Bronchofiberscope alveolar lavage is of great significance to reduce mortality and improve clinical rescue efficiency, and is worthy of clinical application and popularization.
- Bronchoscopic alveolar lavage,
- Early intervention,
- AIDS,
- Severe pneumonia

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References(24)

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