Research Progress of Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis

Yunxin ZHAO; Fanyuan MENG; Wei LIU; Huidong WU; Changliang LUO; Bin LI; Lijuan AO; Moxian CHEN

doi:10.12259/j.issn.2095-610X.S20221121

Volume 43 Issue 11

Nov. 2022

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Yunxin ZHAO, Fanyuan MENG, Wei LIU, Huidong WU, Changliang LUO, Bin LI, Lijuan AO, Moxian CHEN. Research Progress of Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis[J]. Journal of Kunming Medical University, 2022, 43(11): 156-164. doi: 10.12259/j.issn.2095-610X.S20221121

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Yunxin ZHAO, Fanyuan MENG, Wei LIU, Huidong WU, Changliang LUO, Bin LI, Lijuan AO, Moxian CHEN. Research Progress of Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis[J]. Journal of Kunming Medical University, 2022, 43(11): 156-164. doi: 10.12259/j.issn.2095-610X.S20221121

Citation:

Yunxin ZHAO, Fanyuan MENG, Wei LIU, Huidong WU, Changliang LUO, Bin LI, Lijuan AO, Moxian CHEN. Research Progress of Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis[J]. Journal of Kunming Medical University, 2022, 43(11): 156-164. doi: 10.12259/j.issn.2095-610X.S20221121

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Research Progress of Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis

doi: 10.12259/j.issn.2095-610X.S20221121

1.
School of Rehabilitation，Kunming Medical University，Kunming Yunnan 650500
2.
Dept. of Children’s Health，Kaiyuan People’s Hospital，Kaiyuan Yunnan 661600，China

Received Date: 2022-01-24
Publish Date: 2022-11-25

Abstract

Abstract

The incidence of adolescent idiopathic scoliosis （AIS） worldwide is 1%～3%, the base of the diseased population is large, and it causes both physical and psychological pains to patients. Numerous studies have shown that genetic factors may play an important role in the occurrence and development of AIS. The correlation between single nucleotide polymorphisms （SNPs） and AIS is the focus of medical molecular research in recent years. In-depth research on the SNPs of susceptibility genes will help to explore new strategies for the prevention, diagnosis and treatment of AIS. This article reviews the research advances concerning gene SNPs and AIS susceptibility.
- Adolescent idiopathic scoliosis,
- Genes,
- Polymorphism,
- Single nucleotide,
- Nationality

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References(49)

References

[1]	Menger R P, Sin A H. Adolescent and idiopathic scoliosis [M]. Treasure Island （FL）: StatPearls, 2021: 29763083.
[2]	Essex R,Bruce G,Dibley M,et al. A systematic scoping review and textual narrative synthesis of long-term health-related quality of life outcomes for adolescent idiopathic scoliosis[J]. International Journal of Orthopaedic and Trauma Nursing,2021,40(3):100844.
[3]	Zamborsk R,Liščák B,Trepáč M,et al. Adolescent idiopathic scoliosis - future molecular-based diagnostic and prognostic testing[J]. Ortop Traumatol Rehabil,2019,21(4):253-260. doi: 10.5604/01.3001.0013.5070
[4]	Mukhtar M,Sargazi S,Barani M,et al. Application of nanotechnology for sensitive detection of low-abundance single-nucleotide variations in genomic DNA:A review[J]. Nanomaterials (Basel),2021,11(6):1384. doi: 10.3390/nano11061384
[5]	Zhao L,Roffey D M,Chen S. Association between the estrogen receptor beta (ESR2) rs1256120 single nucleotide polymorphism and adolescent idiopathic scoliosis:A systematic review and meta-analysis[J]. Spine,2017,42(11):871-878. doi: 10.1097/BRS.0000000000001932
[6]	Janusz P,Kotwicki T,Andrusiewicz M,et al. XbaI and PvuII polymorphisms of estrogen receptor 1 gene in females with idiopathic scoliosis:No association with occurrence or clinical form[J]. PLoS One,2013,8(10):e76806. doi: 10.1371/journal.pone.0076806
[7]	Takahashi Y,Matsumoto M,Karasugi T,et al. Replication study of the association between adolescent idiopathic scoliosis and two estrogen receptor genes[J]. J Orthop Res,2011,29(6):834-837. doi: 10.1002/jor.21322
[8]	Sobhan M R,Mahdinezhad-Yazdi M,Dastgheib S A,et al. Association of ESRα XbaI A > G,ESRα PvuII T > C and ESRβ AlwNI T > C Polymorphisms with the risk of developing adolescent idiopathic scoliosis:A systematic review and genetic meta-analysis[J]. Revista Brasileira de Ortopedia,2020,55(1):8-16. doi: 10.1016/j.rboe.2018.03.001
[9]	高军胜,张陆,刘志昂,等. IL-6基因多态性与青少年特发性脊柱侧凸易感性及支具矫形疗效的相关性研究[J]. 中国修复重建外科杂志,2018,32(6):678-684. doi: 10.7507/1002-1892.201710054
[10]	Murakami M,Nishimoto N. IL-6 inhibitors prevent bone loss and cartilage degeneration in rheumatoid arthritis[J]. Clin Calcium,2015,25(12):1851-1857.
[11]	Teles Filho R V,Abe G D M,Daher M T. Genetic Influence in disc degeneration - systematic review of literature[J]. Revista Brasileira de Ortopedia,2020,55(2):131-138. doi: 10.1055/s-0039-1692626
[12]	Dai Z,Wang Y,Wu Z,et al. Female-specific susceptibility locus in BOC and SEC16B are associated with adolescent idiopathic scoliosis[J]. Spine (Phila Pa,1976),2021,46(22):e1178-e1184.
[13]	Sui W,Yang J,Huang Z,et al. Polymorphisms in promoter regions of MMP-3 and IL-6 genes are not associated to adolescent idiopathic scoliosis (AIS) gender bias[J]. Journal of Back and Musculoskeletal Rehabilitation,2017,30(3):559-563. doi: 10.3233/BMR-150309
[14]	Mórocz M,Czibula A,Grózer Z B,et al. Association study of BMP4,IL6,Leptin,MMP3,and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis[J]. Spine (Phila Pa,1976),2011,36(2):E123-E130.
[15]	Aulisa L,Papaleo P,Pola E,et al. Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis:A case-control study[J]. Spine (Phila Pa,1976),2007,32(24):2700-2702.
[16]	Sobhan M R,Mahdinezhad-Yazdi M,Dastgheib S A,et al. Association of the IL-6 -174G > C (rs1800795) polymorphism with adolescent idiopathic scoliosis:Evidence from a case-control study and meta-analysis[J]. Revista Brasileira De Ortopedia,2020,55(1):17-26. doi: 10.1055/s-0039-1700813
[17]	周传坤,高书涛,王鹏,等. MMP-3 rs3025058和IL-6 rs1800795单核苷酸多态性与特发性脊柱侧凸相关性的Meta分析[J]. 中国脊柱脊髓杂志,2018,28(3):219-227. doi: 10.3969/j.issn.1004-406X.2018.03.05
[18]	Luo M,Zhang Y,Huang S,et al. The susceptibility and potential functions of the LBX1 gene in adolescent idiopathic scoliosis[J]. Front Genet,2020,11(1):614984.
[19]	Kou I,Takahashi Y,Johnson T A,et al. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis[J]. Nat Genet,2013,45(6):676-679. doi: 10.1038/ng.2639
[20]	Zhao J,Li M,Bradfield J P,et al. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature[J]. BMC Med Genet,2010,11(6):96.
[21]	Lettre G,Jackson A U,Gieger C,et al. Identification of ten loci associated with height highlights new biological pathways in human growth[J]. Nat Genet,2008,40(5):584-591. doi: 10.1038/ng.125
[22]	Li Y L, Gao S J, Xu H, et al. The association of rs11190870 near LBX1 with the susceptibility and severity of AIS, a meta-analysis [J]. Int J Surg, 2018, 54（Pt A）: 193-200.
[23]	Man G C,Tang N L,Chan T F,et al. Replication study for the association of GWAS-associated loci with adolescent idiopathic scoliosis susceptibility and curve progression in a chinese population[J]. Spine (Phila Pa,1976),2019,44(7):464-471.
[24]	Liu S,Wu N,Zuo Y,et al. Genetic polymorphism of LBX1 is associated with adolescent idiopathic scoliosis in northern chinese Han population[J]. Spine (Phila Pa,1976),2017,42(15):1125-1129.
[25]	Grauers A,Wang J,Einarsdottir E,et al. Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis[J]. Spine J,2015,15(10):2239-2246. doi: 10.1016/j.spinee.2015.05.013
[26]	Nada D,Julien C,Samuels M E,et al. A replication study for association of LBX1 locus with adolescent idiopathic scoliosis in French-Canadian population[J]. Spine (Phila Pa,1976),2018,43(3):172-178.
[27]	Chettier R,Nelson L,Ogilvie J W,et al. Haplotypes at LBX1 have distinct inheritance patterns with opposite effects in adolescent idiopathic scoliosis[J]. PLoS One,2015,10(2):e0117708. doi: 10.1371/journal.pone.0117708
[28]	Kou I,Watanabe K,Takahashi Y,et al. A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis[J]. Sci Rep,2018,8(1):11575. doi: 10.1038/s41598-018-29011-7
[29]	Londono D,Kou I,Johnson T A,et al. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups[J]. J Med Genet,2014,51(6):401-406. doi: 10.1136/jmedgenet-2013-102067
[30]	Jiang H,Yang Q,Liu Y,et al. Association between ladybird homeobox 1 gene polymorphisms and adolescent idiopathic scoliosis:A moose-compliant meta-analysis[J]. Medicine (Baltimore),2019,98(27):e16314.
[31]	Kruse L M,Buchan J G,Gurnett C A,et al. Polygenic threshold model with sex dimorphism in adolescent idiopathic scoliosis:The carter effect[J]. J Bone Joint Surg Am,2012,94(16):1485-1491. doi: 10.2106/JBJS.K.01450
[32]	Regitz-Zagrosek V,Kararigas G. Mechanistic pathways of sex differences in cardiovascular disease[J]. Physiol Rev,2017,97(1):1-37. doi: 10.1152/physrev.00021.2015
[33]	Chowdhury N U,Guntur V P,Newcomb D C,et al. Sex and gender in asthma[J]. Eur Respir Rev,2021,30(162):210067. doi: 10.1183/16000617.0067-2021
[34]	Nebel R A,Aggarwal N T,Barnes L L,et al. Understanding the impact of sex and gender in Alzheimer's disease:A call to action[J]. Alzheimers Dement,2018,14(9):1171-1183. doi: 10.1016/j.jalz.2018.04.008
[35]	Sharma S,Londono D,Eckalbar W L,et al. A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females[J]. Nature Communications,2015,6(1):6452. doi: 10.1038/ncomms7452
[36]	Sizar O, Khare S, Goyal A, et al. Vitamin D Deficiency [M]. Treasure Island （FL）: StatPearls, 2021: 30335299.
[37]	Schwenk R W,Vogel H,Schürmann A. Genetic and epigenetic control of metabolic health[J]. Mol Metab,2013,2(4):337-347. doi: 10.1016/j.molmet.2013.09.002
[38]	Sivakamasundari V,Kraus P,Sun W,et al. A developmental transcriptomic analysis of PAX1 and PAX9 in embryonic intervertebral disc development[J]. Biol Open,2017,6(2):187-199.
[39]	Xu L,Sheng F,Xia C,et al. Genetic variant of PAX1 gene is functionally associated with adolescent idiopathic scoliosis in the Chinese population[J]. Spine,2018,43(7):492-496. doi: 10.1097/BRS.0000000000002475
[40]	Liu G,Liu S,Li X,et al. Genetic polymorphisms of PAX1 are functionally associated with different PUMC types of adolescent idiopathic scoliosis in a northern Chinese Han population[J]. Gene,2019,688(3):215-220.
[41]	Kou I,Otomo N,Takeda K,et al. Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese[J]. Nature Communications,2019,10(1):3685-3685. doi: 10.1038/s41467-019-11596-w
[42]	Yin X,Cheng H,Lin Y,et al. A weighted polygenic risk score using 14 known susceptibility variants to estimate risk and age onset of psoriasis in Han Chinese[J]. PLoS One,2015,10(5):e0125369. doi: 10.1371/journal.pone.0125369
[43]	Sabik O L,Farber C R. Using GWAS to identify novel therapeutic targets for osteoporosis[J]. Transl Res,2017,181(5):15-26.
[44]	Zhang F R,Liu H,Irwanto A,et al. HLA-B*13:01 and the dapsone hypersensitivity syndrome[J]. N Engl J Med,2013,369(17):1620-1628. doi: 10.1056/NEJMoa1213096
[45]	Ma X,Yang W,Gao Y,et al. Genetic origins and sex-biased admixture of the huis[J]. Mol Biol Evol,2021,38(9):3804-3819. doi: 10.1093/molbev/msab158
[46]	杨昭庆,禇嘉祐. 中国人类遗传多样性研究进展[J]. 遗传,2012,34(11):1351-1364.
[47]	Li Y H,Luo J Y,Fang B B,et al. Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations[J]. Hereditas,2021,158(1):16. doi: 10.1186/s41065-021-00180-2
[48]	Wang T,Sun L,Xu L,et al. Prevalence of dyslipidemia and gene polymorphisms of ABCB1 and SLCO1B1 in Han,Uygur,Kazak,Hui,Tatar,Kirgiz,and Sibe populations with coronary heart disease in Xinjiang,China[J]. Lipids Health Dis,2021,20(1):116. doi: 10.1186/s12944-021-01544-3
[49]	Peng Y,Wang S R,Qiu G X,et al. Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis[J]. Chin Med J (Engl),2020,133(4):483-493. doi: 10.1097/CM9.0000000000000652

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