Progress in Etiology and Pathogenesis of Liver Fibrosis

Di HE; Peng CHEN; Feng LIU; Yang XU; Lei HAN; Wenjing DING

doi:10.12259/j.issn.2095-610X.S20221122

Volume 43 Issue 11

Nov. 2022

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Di HE, Peng CHEN, Feng LIU, Yang XU, Lei HAN, Wenjing DING. Progress in Etiology and Pathogenesis of Liver Fibrosis[J]. Journal of Kunming Medical University, 2022, 43(11): 165-171. doi: 10.12259/j.issn.2095-610X.S20221122

Citation:

Di HE, Peng CHEN, Feng LIU, Yang XU, Lei HAN, Wenjing DING. Progress in Etiology and Pathogenesis of Liver Fibrosis[J]. Journal of Kunming Medical University, 2022, 43(11): 165-171. doi: 10.12259/j.issn.2095-610X.S20221122

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Progress in Etiology and Pathogenesis of Liver Fibrosis

doi: 10.12259/j.issn.2095-610X.S20221122

Di HE¹,
Peng CHEN^{1
,
,},
Feng LIU¹,
Yang XU¹,
Lei HAN¹,
Wenjing DING²

1.
Dept. of Hepatobiliary and Pancreatic Surgery，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
2.
Dept. of Clinical Medicine，Advanced School of Chinese Medicine in Baoshan，Baoshan Yunnan 678000，China

Received Date: 2022-01-16
Available Online: 2022-10-29
Publish Date: 2022-11-14

Abstract

Abstract

Liver fibrosis （HF） is the result of abnormal deposition of various extracellular matrix （ECM） caused by the over-repair response of various chronic liver diseases, such as genetic-related diseases, chronic viral hepatitis, alcoholic hepatitis, cholestasis and drug-induced liver injury. The pathogenesis of hepatic fibrosis is related to hepatic stellate cell （HSC）, hepatic macrophage, endoplasmic reticulum stress （ERs） and autophagy. Liver fibrosis is a dynamic process that can progress to cirrhosis or even hepatocellular carcinoma without intervention. Therefore, delaying or reversing the occurrence of liver fibrosis has very important clinical significance. The purpose of this review is to summarize the etiology, occurrence and development mechanism of liver fibrosis and provide a reference for the research of anti-liver fibrosis drugs.
- Liver fibrosis,
- Etiology,
- Hepatic stellate cell,
- Endoplasmic reticulum stress

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References(49)

References

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