Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace

Huajun ZHAO; Guoqing PAN; Ying TANG; Zhiyuan WANG; Xiaowei ZHAO; Xiaoyu TUO

doi:10.12259/j.issn.2095-610X.S20221128

Volume 43 Issue 11

Nov. 2022

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Huajun ZHAO, Guoqing PAN, Ying TANG, Zhiyuan WANG, Xiaowei ZHAO, Xiaoyu TUO. Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace[J]. Journal of Kunming Medical University, 2022, 43(11): 22-29. doi: 10.12259/j.issn.2095-610X.S20221128

Citation:

Huajun ZHAO, Guoqing PAN, Ying TANG, Zhiyuan WANG, Xiaowei ZHAO, Xiaoyu TUO. Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace[J]. Journal of Kunming Medical University, 2022, 43(11): 22-29. doi: 10.12259/j.issn.2095-610X.S20221128

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Expressions of ROR1 in Lung Adenocarcinoma and Its Relationship with Spread Through Air Apace

doi: 10.12259/j.issn.2095-610X.S20221128

1.
Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
2.
Dept. of Pathology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
Electron Microscopy Lab，School of Basic Medicine，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2022-07-18
Available Online: 2022-10-28
Publish Date: 2022-11-14

Abstract

Abstract

Objective To study the relationship between the expression of receptor tyrosine kinase-like orphan receptor 1 （ROR1） and spread through air space （STAS） in lung adenocarcinoma tissues. Methods We collected 618 cases of lung adenocarcinoma from June 2017 to January 2, 2022, HE staining section was used to determine pathological subtypes and pathological characteristics, count STAS number and grade. The expression of ROR1 was detected by immunohistochemistry staining in different pathological subtypes of lung adenocarcinoma and the relationship with STAS quantity was analyzed. Results ROR1 expressions were higher in micropapillary and solid lung adenocarcinoma （poorly differentiated）（P < 0.001）; ROR1 expression rates were 88.0%, 94.1% in low STAS and high STAS groups, significantly higher than no STAS group （P < 0.001）. Conclusions ROR1 is highly expressed in poorly differentiated lung adenocarcinoma and suggests a higher incidence of STAS. ROR1 is expected to be a new diagnostic biomarker of lung adenocarcinoma for guiding clinical treatment and assisting prognostic judgment, and may be a potential therapeutic target for STAS-positive lung adenocarcinoma.
- Lung adenocarcinoma,
- ROR1,
- Spread through air space,
- Pathological subtypes,
- Immunohistochemistry

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References(27)

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