Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma

Yao ZOU; Ziyu WANG; Jiao LI; Xingxin LI; Yaqiong SHEN; Jing XU; Yan JIN

doi:10.12259/j.issn.2095-610X.S20221215

Volume 43 Issue 12

Dec. 2022

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Yao ZOU, Ziyu WANG, Jiao LI, Xingxin LI, Yaqiong SHEN, Jing XU, Yan JIN. Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(12): 81-87. doi: 10.12259/j.issn.2095-610X.S20221215

Citation:

Yao ZOU, Ziyu WANG, Jiao LI, Xingxin LI, Yaqiong SHEN, Jing XU, Yan JIN. Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(12): 81-87. doi: 10.12259/j.issn.2095-610X.S20221215

Citation:

Yao ZOU, Ziyu WANG, Jiao LI, Xingxin LI, Yaqiong SHEN, Jing XU, Yan JIN. Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(12): 81-87. doi: 10.12259/j.issn.2095-610X.S20221215

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Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma

doi: 10.12259/j.issn.2095-610X.S20221215

Dept. of Hepatobiliary Surgery，The 1st People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

Received Date: 2022-08-22
Available Online: 2022-12-05
Publish Date: 2022-12-25

Abstract

Abstract

Objective To investigate the expression of lysoxygenase-like protein 2 （LOXL2） and Snail in the tissues of cholangiocarcinoma （CCA） and their association with clinicopathological features and postoperative survival. Methods 31 patients with cholangiocarcinoma who underwent surgical removal in the First People’s Hospital of Yunnan Province from 2014 to 2021 and their follow-up data were collected. The expression of LOXL2 and Snail in cancer tissues and adjacent normal tissues of patients was detected by immunohistochemical staining, and the association between the expression of the two proteins and clinicopathological data and prognosis was analyzed. Results The expression levels of LOXL2 and Snail in tumor tissues were significantly higher than those in adjacent tissues, and there was a positive correlation between LOXL2 expression and Snail expression （r = 0.430, P = 0.016）. Snail expression was associated with lymph node metastasis （P = 0.025）. Compared with patients with high expression of LOXL2 and Snail, patients with low expression of LOXL2 and Snail had higher overall survival rate （all P < 0.05）. Univariate survival analysis showed that high expression of Snail and lymph node metastasis were associated with worse prognosis in patients with cholangiocarcinoma （all P < 0.05）. Multivariate Cox survival analysis showed that lymph node metastasis might be an independent prognostic factor for patients with cholangiocarcinoma （P = 0.017）. Conclusion The expression of LOXL2 and Snail is increased in cholangiocarcinoma tissues, and the expression of LOXL2 and Snail is closely related. The overexpression of Snail may be more prone to lymph node metastasis and promote the invasive behavior of tumor cells, and lymph node metastasis may be an independent factor affecting the prognosis of cholangiocarcinoma patients. Patients with LOXL2 and Snail overexpression have a relatively low postoperative survival rate.Therefore, the combined detection of LOXL2 and Snail is of great significance for the prognosis of patients with cholangiocarcinoma.
- Cholangiocarcinoma,
- LOXL2,
- Snail,
- Invasive metastasis,
- Epithelial mesenchymal transition,
- Prognosis

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References(35)

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