Efficacy of Xinmailong Injection on Septic Cardiomyopathy

Wenzhuo LI; Li YANG; Jing XIA

doi:10.12259/j.issn.2095-610X.S20221221

Volume 43 Issue 12

Dec. 2022

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Wenzhuo LI, Li YANG, Jing XIA. Efficacy of Xinmailong Injection on Septic Cardiomyopathy[J]. Journal of Kunming Medical University, 2022, 43(12): 111-116. doi: 10.12259/j.issn.2095-610X.S20221221

Citation:

Wenzhuo LI, Li YANG, Jing XIA. Efficacy of Xinmailong Injection on Septic Cardiomyopathy[J]. Journal of Kunming Medical University, 2022, 43(12): 111-116. doi: 10.12259/j.issn.2095-610X.S20221221

Wenzhuo LI, Li YANG, Jing XIA. Efficacy of Xinmailong Injection on Septic Cardiomyopathy[J]. Journal of Kunming Medical University, 2022, 43(12): 111-116. doi: 10.12259/j.issn.2095-610X.S20221221

Citation:

Wenzhuo LI, Li YANG, Jing XIA. Efficacy of Xinmailong Injection on Septic Cardiomyopathy[J]. Journal of Kunming Medical University, 2022, 43(12): 111-116. doi: 10.12259/j.issn.2095-610X.S20221221

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Efficacy of Xinmailong Injection on Septic Cardiomyopathy

doi: 10.12259/j.issn.2095-610X.S20221221

Dept. of Emergency Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-06-19
Publish Date: 2022-12-25

Abstract

Abstract

Objective To explore the efficacy of Xinmailong injection on septic cardiomyopathy. Methods A randomized controlled, single-blind study was conducted. 36 patients diagnosed with septic cardiomyopathy were randomly divided into control group （n = 19） and cardiomyopathy group （n = 17）. All patients in the 2 groups were given standardized treatment according to the 2018 International Guidelines for the Management of Sepsis and Septic Shock, and hemodynamic monitoring was performed by PICCO monitor during treatment. The experimental group was treated with Xinmailong injection on the basis of standard treatment, and the control group was injected with 0.9% sodium chloride injection at the same time. Peripheral venous blood was extracted from patients before treatment, 24 h, 72 h and 120 h after treatment, respectively, to detect troponin I and B brain natriuretic peptide, Doppler echocardiography was used to evaluate cardiac function, and hemodynamic blood related indexes showed by PICCO were compared.The experimental data were statistically analyzed by SPSS 19.0 statistical software. Results Compared with the control group, the levels of Cardiac Troponin I and brain natriuretic peptide B in experimental groups were significantly decreased. Left ventricular ejection fraction （LVEF）, tricuspid annular plane systolic excursion （TAPSE）, E/A increased, E peak deceleration time decreased; Stroke volume index （SVI） and cardiac function index （CFI） increased, and the difference was statistically significant （P < 0.05）. Conclusion Xinmailong injection can improve the cardiac function of patients with septic cardiomyopathy.
- Xinmailong injection,
- Sepsis,
- Myocardial suppression

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References(21)

References

[1]	田慈,谢苗荣. 脓毒症心肌损伤机制的研究进展[J]. 临床和实验医学杂志,2013,12(2):148-150.
[2]	Lv X,Wang H. Pathophysiology of sepsis-induced myocardial dysfunction[J]. Military Medical Research,2016,3(4):202-211.
[3]	Wacharasint P,Nakada T A,Boyd J H. Normal-range blood lactate concentration in septic shock is prognostic and predictive[J]. Shock,2012,38(1):4-10. doi: 10.1097/SHK.0b013e318254d41a
[4]	黄小春. 心脉隆注射液联合常规临床干预治疗冠心病并发心力衰竭患者的效果[J]. 中外医学研究,2022,20(28):134-137.
[5]	周杨,彭芳. 心脉隆注射液与多种药物治疗心力衰竭的疗效和安全性分析[J]. 当代医药论丛,2020,18(13):60-63.
[6]	李真玉,陈兵,李广平. 脓毒症心肌抑制的诊治进展[J]. 中国循环杂志,2015,30(07):705-707.
[7]	肖军,唐发宽,王洪叶. 心脉隆注射液对急性心肌梗死患者脑钠肽的影响及其临床意义[J]. 医学综述,2010,16(17):2679-2681.
[8]	Rognoni A,Lupi A,Lazzero M. Levosimendan:From basic science to clinical trials[J]. Recent Pat Cardiovasc Drug Discov,2011,6(1):9-15. doi: 10.2174/157489011794578455
[9]	Morgan P,Al-Subaie N,Rhodes A. Minimally invasive cardiac output monitoring[J]. Curr Opin Crit Care,2008,14(3):322-326. doi: 10.1097/MCC.0b013e3282fd6e4a
[10]	Lena M Napolitano. Sepsis 2018:Definitions and guideline changes[J]. Surg Infect (Larchmt),2018,19(2):117-125. doi: 10.1089/sur.2017.278
[11]	样雪婷, 张惠锋. 补产超广谱β-内酰胺酶肠杆菌科细菌感染患者使用抗菌药物的药物评价[J]昆明医科大学学报, 2022, 43 （6）: 74-78.
[12]	Hochstadt A,Meroz Y,Landesberg G. Myocardial dysfunction in severe sepsis and septic shock:More questions than answers[J]. J Cardiothorac Vasc Anesth,2011,25(3):526-535.
[13]	潘小进,孙华. 兔脓毒症早期心肌功能的变化[J]. 中国危重病急救医学,2004,16(6):355-357.
[14]	江利冰,李瑞杰,张斌,等. 2016年脓毒症与脓毒性休克处理国际指南[J]. 中华急诊医学杂志,2017,26(3):263-266.
[15]	刘峰宇,孙同文. 脓毒症心肌病的诊疗进展[J]. 中华急诊医学杂志,2022,31(7):858-861.
[16]	耿丽娟,李素玮,张永利,等. 脓毒症心肌损伤发病机制的研究进展[J]. 中华内科杂志,2015,54(1):77-80.
[17]	王维雯,李德霞,张杰,等. 射血分数降低的心力衰竭患者血清可溶性ST2与心脏重构的相关性[J]. 昆明医科大学学报,2021,42(08):71-77.
[18]	Kakihana Y,Ito T,Nakahara M,et al. Sepsis-induced myocardial dysfunction:Pathophysiology and management[J]. J Intensive Care,2016,4(1):22. doi: 10.1186/s40560-016-0148-1
[19]	Esper A M,Martin G S. Extending international sepsis epidemiology:The impact of organ dysfunction[J]. Crit Care,2009,13(1):120. doi: 10.1186/cc7704
[20]	Rhodes A,Evans L E,Alhazzani W,et al. Surviving sepsis campaign: International guidelines for management of sepsis and septic shock:2016[J]. Intensive Care Med,2017,43(3):304-377.
[21]	卢年芳,於江泉,邵俊,等. 超声心动图心室功能指标与脓毒症患者预后关系的研究[J]. 中华危重病急救医学,2022,34(7):740-745.

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