Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin

Yue XU; Chan WANG; Shucheng LIN; Huijie ZHANG; Yi TAN; Shuwei ZHANG; Xiaofeng ZENG; Zhen LI

doi:10.12259/j.issn.2095-610X.S20221228

Volume 43 Issue 12

Dec. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(12): 153-158

Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin[J]. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228

Citation:

Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin[J]. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228

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Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin

doi: 10.12259/j.issn.2095-610X.S20221228

School of Forensic Science，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2022-04-19
Available Online: 2022-12-06
Publish Date: 2022-12-25

Abstract

Abstract

Amanita is a genus of mushrooms that can cause acute poisoning, and more than 90% of wild mushroom poisoning deaths are caused by its toxins. α-amanitin （α-AMA） is the most toxic component, and the liver is the major target of its toxicity. Transcriptional inhibition of RNA polymerase Ⅱ （RNA polⅡ） is a recognized mechanism of α-amanita toxin-induced hepatocyte injury, but other possible toxicological mechanisms are yet to be identified. The article reviews the toxic mechanisms of α-amanitin induced apoptosis, autophagy, inflammation and oxidative stress in hepatocytes, and the clinical treatment after poisoning, aiming to provide new directions for the research and prevention of Amanita poisoning.
- α-amanitin,
- Hepatotoxicity,
- Mechanism of action,
- Clinical treatment

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References(44)

References

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