Correlation of the Expression of miR-192 in Serum Expression with Left Ventricular Hypertrophy in Patients with Essential Hypertension

Gaobo DU; Xiaofeng JIA; Qiang YU; Xiaojuan LI

doi:10.12259/j.issn.2095-610X.S20230204

Volume 44 Issue 2

Feb. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(2): 139-143

Gaobo DU, Xiaofeng JIA, Qiang YU, Xiaojuan LI. Correlation of the Expression of miR-192 in Serum Expression with Left Ventricular Hypertrophy in Patients with Essential Hypertension[J]. Journal of Kunming Medical University, 2023, 44(2): 139-143. doi: 10.12259/j.issn.2095-610X.S20230204

Citation:

Gaobo DU, Xiaofeng JIA, Qiang YU, Xiaojuan LI. Correlation of the Expression of miR-192 in Serum Expression with Left Ventricular Hypertrophy in Patients with Essential Hypertension[J]. Journal of Kunming Medical University, 2023, 44(2): 139-143. doi: 10.12259/j.issn.2095-610X.S20230204

Citation:

Gaobo DU, Xiaofeng JIA, Qiang YU, Xiaojuan LI. Correlation of the Expression of miR-192 in Serum Expression with Left Ventricular Hypertrophy in Patients with Essential Hypertension[J]. Journal of Kunming Medical University, 2023, 44(2): 139-143. doi: 10.12259/j.issn.2095-610X.S20230204

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Correlation of the Expression of miR-192 in Serum Expression with Left Ventricular Hypertrophy in Patients with Essential Hypertension

doi: 10.12259/j.issn.2095-610X.S20230204

Dept. of Cardiovascular Medicine，Huangshi Central Hospital，Affiliated Hospital of Hubei Institute of Technology，Huangshi Hebei 435000，China

Received Date: 2022-12-14
Available Online: 2023-01-31
Publish Date: 2023-02-25

Abstract

Abstract

Objective To investigate the correlation between the expression of miR-192 in serum and left ventricular hypertrophy in patients with essential hypertension. Methods The clinical data of 187 patients with essential hypertension treated from June 2018 to December 2019 were selected. All patients were accepted echocardiography to obtain the indexes of LVPWd, IVST, LVEDD, LVESD, LVEDV, LVESV, LAD, LVEF and LVMI. And according to the results of echocardiography, the patients were divided into the hypertrophic group and control group. The expression of miR-192 in serum was detected by real-time fluorescence quantitative PCR. The levels of TGF-β1, type I procollagen carboxy terminal peptide （PⅠCP） and type III procollagen amino terminal peptide （PⅢNP） were detected by using ELISA. Results According to the results of echocardiography, 76 cases of patients had left ventricular hypertrophy （hypertrophy group）, and 111 cases had no left ventricular hypertrophy （control group）. Compared with the control group, LVPWT, IVST, LVEDD, LVESD, LVEDV, LVESV, LAD, LVMI, and hs-CRP in the hypertrophic group were all increased （P < 0.05）, the serum levels of miR-192, TGF-β1, PⅢNP and PⅠCP in the hypertrophic group were increased （P < 0.05）. Pearson correlation analysis showed that the serum level of miR-192 in patients with essential hypertension was positively correlated with the LVPWT, IVST, LVEDD, LVESD, LVEDV, LVESV, LAD, LVMI, TGF-β1, PⅠCP and PⅢNP （P < 0.05）. The results of multiple linear regression analysis showed that the LVPWT, IVST, LVEDD, LVESV, TGF-β1, PⅠCP, and PⅢNP were related factors that affected serum level of miR-192 in patients with essential hypertension （P < 0.05）. Conclusion The serum level of miR-192 is elevated in patients with essential hypertension and left ventricular hypertrophy, and is related to the degree of left ventricular hypertrophy and myocardial fibrosis.
- miR-192,
- Left ventricular hypertrophy,
- Myocardial fibrosis,
- Essential hypertension

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