Application of NICS Testing at Different Stages in PGT Treatment of Patients with Reciprocal Translocation

Mingying LI; Minyao LI; Jiacong YAN; Mei TIAN; Yonggang LI

doi:10.12259/j.issn.2095-610X.S20230207

Volume 44 Issue 2

Feb. 2023

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Mingying LI, Minyao LI, Jiacong YAN, Mei TIAN, Yonggang LI. Application of NICS Testing at Different Stages in PGT Treatment of Patients with Reciprocal Translocation[J]. Journal of Kunming Medical University, 2023, 44(2): 69-74. doi: 10.12259/j.issn.2095-610X.S20230207

Citation:

Mingying LI, Minyao LI, Jiacong YAN, Mei TIAN, Yonggang LI. Application of NICS Testing at Different Stages in PGT Treatment of Patients with Reciprocal Translocation[J]. Journal of Kunming Medical University, 2023, 44(2): 69-74. doi: 10.12259/j.issn.2095-610X.S20230207

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Application of NICS Testing at Different Stages in PGT Treatment of Patients with Reciprocal Translocation

doi: 10.12259/j.issn.2095-610X.S20230207

1.
Dept. of Reproduction medicine，First People’s Hospital of Yunnan Province，Kunming Yunnan 650032
2.
School of Life Sciences，Yunnan University， Kunming Yunnan 650500，China

Received Date: 2022-12-26
Available Online: 2023-01-31
Publish Date: 2023-02-25

Abstract

Abstract

Objective To study the application of NICS of different stages in the PGT treatment for patients with balanced translocation. Methods The parameters analyzed included testing results （tested successfully and rested failed） and CNVs results （normal and abnormal）; the samples were divided into D3 NICS, D5 NICS, whole embryos and biopsied cells （embryo /TE） groups according to the samples types. The testing failure rate and CNVs results distribution were compared among the groups. Results There were significant differences between D3 NICS group and embryo/TE group on testing failure rate and CNVs results distribution （P < 0.001/P < 0.01）, while no significant difference was shown in results between D5 NICS group and embryo /TE group （P > 0.05）. Conclusions Compared with D3 NICS, D5 NICS has more advantages in the application of balanced translocation embryos diagnosis. As a non-invasive test, D5 NICS is expected to replace the traditional biopsy technique in treatment of balanced translocation patients with the progress of manipulation methods and sequencing technology.
- Reciprocal translocation,
- NICS,
- PGT

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References(18)

References

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