Volume 44 Issue 2
Feb.  2023
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Yupeng LI, Xinglong CHEN, Shengxing YUAN, Yajuan CHEN, Rongping ZHANG. Chemical Compounds Isolated from Cremastra Appendiculata and Their Bioactive Activity[J]. Journal of Kunming Medical University, 2023, 44(2): 1-6. doi: 10.12259/j.issn.2095-610X.S20230209
Citation: Yupeng LI, Xinglong CHEN, Shengxing YUAN, Yajuan CHEN, Rongping ZHANG. Chemical Compounds Isolated from Cremastra Appendiculata and Their Bioactive Activity[J]. Journal of Kunming Medical University, 2023, 44(2): 1-6. doi: 10.12259/j.issn.2095-610X.S20230209
shu

Chemical Compounds Isolated from Cremastra Appendiculata and Their Bioactive Activity

doi: 10.12259/j.issn.2095-610X.S20230209
  • 1.

    School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500

  • 2.

    School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization，Yunnan University of Chinese Medicine y，Kunming Yunnan 650500

  • 3.

    Dept. of Ultrasound，the First People’s Hospital of Qujing City，Yunnan Province，Kunming Yunnan 655000

  • 4.

    School of Rehabilitation，Kunming Medical University， Kunming Yunnan 650500，China

  • Received Date: 2022-12-16
    Available Online: 2023-01-31
  • Publish Date: 2023-02-25
    Abstract
  •   Objective  To study the chemical compounds from the medicinal plants of Cremastra appendiculata and find its antitumor bioactive compounds.   Methods  The compounds were extracted by alcohol （95%） and isolated by column chromatography on silica gel and Sephadex LH-20. Their structures were identified by spectroscopic analysis （1H NMR, 13CNMR and EIMS）. The antitumor activity of the compounds was studied by MTT assay in vitro.   Results  Twelve compounds were obtained and identified as bisbenzopyran （1）, （22E）-ergosta-6, 22-dien-3β, 5α, 8α-triol （2）, 3β-hydroxycholesta-5-ene （3）, β-sistosterol （4）, pinoresinol （5）, 5, 4′-dihydroxy-7- （4-hydroxybenzoyl） -3′- methoxyflavone （6）, 4-methoxy-2, 3, 7- trihydroxyphenanthrene （7）, 2-hydroxy-4, 7-dimethoxyphenanthrene （8）, 4, 4′-dimethoxy-[1, 1′-biphenanthrene]- 2, 2′, 7, 7′-tetrol （9）, 4, 7, 4′, 9′-tetramethoxy-[1, 1′-biphenanthrene] 2, 2′, 7, 7′-tetrol （10）, Bavachinine （11）, 3-hydroxyphenpropionic acid- （2′-methoxy-4′- carboxy-phenol） ester （12）; . The results of anti-tumor activity test of compounds 7～12 showed that 9 and 10 showed good inhibitory activity on MCF-7/S cell line.  Conclusions   Compounds 2, 3, 5, 7, 10 and 12 were isolated from this plant for the first time. IC50 of 9 and 10 on MCF-7/S cell lines were 2.16 and 5.09 respectively μmol/L.
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