Correlation between KRAS Gene Polymorphism and Non-small Cell Lung Cancer in Yunnan Han Population

Yan LIANG; Lei WANG; Ming LEI; Benchao CHEN; Ping SUN; Shuai LI; Li LIU; Qianrong WANG; Manlin LIAO; Qianli MA

doi:10.12259/j.issn.2095-610X.S20230210

Volume 44 Issue 2

Feb. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(2): 52-60

Yan LIANG, Lei WANG, Ming LEI, Benchao CHEN, Ping SUN, Shuai LI, Li LIU, Qianrong WANG, Manlin LIAO, Qianli MA. Correlation between KRAS Gene Polymorphism and Non-small Cell Lung Cancer in Yunnan Han Population[J]. Journal of Kunming Medical University, 2023, 44(2): 52-60. doi: 10.12259/j.issn.2095-610X.S20230210

Citation:

Yan LIANG, Lei WANG, Ming LEI, Benchao CHEN, Ping SUN, Shuai LI, Li LIU, Qianrong WANG, Manlin LIAO, Qianli MA. Correlation between KRAS Gene Polymorphism and Non-small Cell Lung Cancer in Yunnan Han Population[J]. Journal of Kunming Medical University, 2023, 44(2): 52-60. doi: 10.12259/j.issn.2095-610X.S20230210

Citation:

Yan LIANG, Lei WANG, Ming LEI, Benchao CHEN, Ping SUN, Shuai LI, Li LIU, Qianrong WANG, Manlin LIAO, Qianli MA. Correlation between KRAS Gene Polymorphism and Non-small Cell Lung Cancer in Yunnan Han Population[J]. Journal of Kunming Medical University, 2023, 44(2): 52-60. doi: 10.12259/j.issn.2095-610X.S20230210

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Correlation between KRAS Gene Polymorphism and Non-small Cell Lung Cancer in Yunnan Han Population

doi: 10.12259/j.issn.2095-610X.S20230210

1.
College of Nursing Health Sciences，Yunnan Open University，Kunming Yunnan 650500
2.
Dept. of Thoracic Surgery，The Third Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
3.
Kunming Children’s Hospital，Kunming Yunnan 650228，China

Received Date: 2022-12-22
Available Online: 2023-01-31
Publish Date: 2023-02-25

Abstract

Abstract

Objective To investigate the correlation between KRAS gene polymorphism and the occurrence and development of non-small cell lung cancer in Yunnan Han population. Methods In this study, 455 patients with non-small cell lung cancer and 391 healthy controls were selected as the research objects. Three single nucleotide polymorphism （SNP） sites rs12587 （G > T）, rs12245 （A > C）, rs1137282 （A > G） in the 3′UTR region of KRAS gene were identified by Taqman probe genotyping. According to the typing results, the correlations of alleles, genotypes and haplotypes with the occurrence, pathological types （squamous cell carcinoma, adenocarcinoma） and clinical stages （I+II, III+IV） of non-small cell lung cancer were analyzed. Results The distribution frequency of rs12587 （G > T） allele G in the non-small cell lung cancer group was significantly higher than that in the control group （P = 0.008, OR = 1.365, 95%CI 1.086～1.716）. It was carried in the dominant mode Individuals with the T allele （G/T+T/T） had a significantly lower risk of developing non-small cell lung cancer （P = 0.011, OR = 0.70, 95%CI 0.53～0.92）. Case stratification analysis found that the allele and genotype frequencies of the rs12587 （G > T） locus were significantly different between the squamous cell carcinoma group and the control group （P < 0.001, P = 0.001）; Individuals with the T allele （G/T+T/T） had a significantly lower risk of lung squamous cell carcinoma （P < 0.001, OR = 0.45, 95%CI 0.30～0.68）. There was no significant difference in the distribution frequency of the rs12245 （A > C） locus allele and genotype between the non-small cell lung cancer case group and the control group （P > 0.05）; Individuals （A/T+A/A） had a significantly lower risk of developing non-small cell lung cancer （P = 0.028, OR = 0.73, 95%CI 0.55～0.97）. Case stratification analysis found that the allele and genotype frequencies of the rs12245 （A > C） locus were significantly different between the squamous cell carcinoma group and the control group （P = 0.003, P = 0.001）; Individuals with genotype A/T had a significantly lower risk of lung squamous cell carcinoma （P < 0.001, OR = 0.43, 95%CI 0.28～0.67）. Conclusions The G allele of the SNP site rs12587 （G > T） in the 3′UTR region of KRAS gene may be a risk factor for the occurrence of non-small cell lung cancer and squamous cell carcinoma in Yunnan Han population. SNP rs12245 （A > C） allele A may be a protective factor for the occurrence of non-small cell lung cancer in Yunnan Han population.
- Non-small cell lung cancer,
- KRAS,
- SNPs,
- Correlation,
- Yunnan Han population

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