Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy

Rong QIN; Gang SU; Yu ZHANG; Wei YIN; zhen ZHAO

doi:10.12259/j.issn.2095-610X.S20230215

Volume 44 Issue 2

Feb. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(2): 156-160

Rong QIN, Gang SU, Yu ZHANG, Wei YIN, zhen ZHAO. Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy[J]. Journal of Kunming Medical University, 2023, 44(2): 156-160. doi: 10.12259/j.issn.2095-610X.S20230215

Citation:

Rong QIN, Gang SU, Yu ZHANG, Wei YIN, zhen ZHAO. Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy[J]. Journal of Kunming Medical University, 2023, 44(2): 156-160. doi: 10.12259/j.issn.2095-610X.S20230215

Citation:

Rong QIN, Gang SU, Yu ZHANG, Wei YIN, zhen ZHAO. Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy[J]. Journal of Kunming Medical University, 2023, 44(2): 156-160. doi: 10.12259/j.issn.2095-610X.S20230215

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Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy

doi: 10.12259/j.issn.2095-610X.S20230215

Dept. of Anesthesiology，Kunming First People’s Hospital，Kunming Yunnan 650034，China

Received Date: 2022-12-28
Available Online: 2023-02-01
Publish Date: 2023-02-25

Abstract

Abstract

Objective To observe the effect of dolisetron mesylate combined with dexmedetomidine on plasma motilin levels and postoperative complications nausea and vomiting in patients undergoing laparoscopic sleeve gastrectomy. Methods One hundred and twenty ASA Ⅰ-Ⅱ patients, aged 18-60 years, scheduled for elective laparoscopic sleeve gastrectomy, were randomly divided into four groups, each group of 30 patients. Group A: dexmedetomidine+dolasetron mesylate group; Group B: dexmedetomidine group; Group C: dolasetron mesylate group; group D: Saline control group. The general situation, time of operation, blood loss and fluid infusion volume of the four groups were recorded. The plasma motilin level was detected by phletometry before operation （T0） and 24 hours after operation （T1）. The degree and incidence rate of nausea and vomiting after 24 hours and 48 hours were recorded. Results （1） There were no obvious differences in age, gender, BMI, operation time, intraoperative blood loss and intraoperative infusion volume among the four groups. （2） The incidence of grade III and IV postoperative nausea and vomiting and the use of postoperative antiemetics in group A, B and C were lower than those in group D at 24 and 48 hours after operation, and the differences among the four groups were statistically significant （P < 0.01）. （3） The plasma motilin levels in groups A, B and C 24 h after operation were lower than those before operation, and the differences among the three groups were statistically significant （P < 0.01, P < 0.05, P < 0.05）. The motilin levels in groups A, B and C were lower than those in group D 24 hours after operation, and the differences were statistically significant （P < 0.01, P < 0.05, P < 0.05）. Conclusion Dolasetron mesylate combined with dexmedetomidine can significantly reduce the plasma motilin level 24 hours after laparoscopic sleeve gastrectomy, and effectively reduce the severity and incidence of postoperative nausea and vomiting, and is worthy of clinical application.
- Dolisetron mesylate,
- Dexmedetomidine,
- Laparoscopic sleeve gastrectomy,
- Motilin,
- Surgery after nausea and vomiting

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