Jiadai TANG, Jing YANG, Hongli SONG, Jiaojiao CHEN, Zhonghui MIAO, Lin XIE. Correlation of Metastatic and Prognostic Factors in 318 Cases of Primary Gastric Cancer[J]. Journal of Kunming Medical University, 2023, 44(2): 75-87. doi: 10.12259/j.issn.2095-610X.S20230218
Citation: Jiadai TANG, Jing YANG, Hongli SONG, Jiaojiao CHEN, Zhonghui MIAO, Lin XIE. Correlation of Metastatic and Prognostic Factors in 318 Cases of Primary Gastric Cancer[J]. Journal of Kunming Medical University, 2023, 44(2): 75-87. doi: 10.12259/j.issn.2095-610X.S20230218

Correlation of Metastatic and Prognostic Factors in 318 Cases of Primary Gastric Cancer

doi: 10.12259/j.issn.2095-610X.S20230218
  • Received Date: 2022-12-23
  • Publish Date: 2023-02-25
  •   Objective   To explore the influencing factors of metastasis and prognosis in patients with primary gastric cancer (GC), and trying to find out the clinical indicators for early prediction of metastasis.   Methods   A retrospective study was conducted on the clinicopathological data of 318 patients with primary GC who were admitted to Yunnan Cancer Hospital from January 2018 to December 2021 and were divided into 2 groups: metastasis group (213 cases) and non-metastasis group (105 cases) according to whether metastasis occurred. The relationship between clinicopathological factors and GC metastasis and prognosis was analyzed, and the diagnostic efficacy of these factors for GC metastasis was explored.   Results   (1) The median overall survival (OS) and average progression-free survival (PFS) were 27 months and 22.16 months respectively in the metastasis group. While the median OS and average PFS in the non-metastasis group were 45 months and 41.98 months respectively. The differences in OS and PFS between these two groups were statistically significant (P < 0.0001). (2) Multivariate analysis suggested that infiltration depth > mucosal layer, no chemotherapy and carbohydrate antigen-125 (CA-125)≥14.4KU/L were independent risk factors for GC patients with metastasis ( P < 0.05). (3) The drawing of receiver operating characteristic curve (ROC curve) suggested that the combination of infiltration depth, prealbumin and CA-125 had more accurate sensitivity and specificity for predicting GC patients’ metastasis than the combination of double single or indexs. (4) Log-rank test and COX multivariate analysis suggested that total chemotherapy cycle < 8 cycles and CA-125≥14.4KU/L were independent risk factors for OS in patients with metastasis. The independent risk factors for PFS in patients with metastasis were no surgical treatment in the primary lesion, combined with metastasis at initial diagnosis, combined with distant metastasis during the course of disease and CA-125≥14.4KU/L, with statistically significant differences ( P < 0.05).   Conclusions   The prognosis of GC patients with metastasis is truly poor, clinical attention should be paid more attention to the early detection, diagnosis and treatment. The combination of multiple indexs has been proven to be more accurate in sensitivity and specificity for the diagnosis of GC metastasis, suggesting that GC patients should be actively evaluated and individualized treatment should be developed to diagnose and treat after metastasis as soon as possible, to provide a theoretical basis for improving patients’ prognosis, prolonging survival and improving life treatment.
  • [1]
    Joshi S S,Badgwell B D. Current treatment and recent progress in gastric cancer[J]. CA Cancer J Clin,2021,71(3):264-279. doi: 10.3322/caac.21657
    [2]
    Johnston F M,Beckman M. Updates on management of gastric cancer[J]. Curr Oncol Rep,2019,21(8):67. doi: 10.1007/s11912-019-0820-4
    [3]
    Lin M R,Yu L Z,Fu J J. Current treatment status and trends of early gastric cancer in China: analyzed based on the data of China Gastrointestinal Cancer Surgery Union[J]. Chinese Journal of Practical Surgery,2019,39(5):419-423.
    [4]
    Smyth E C,Nilsson M,Grabsch H I,et al. Gastric cancer[J]. Lancet,2020,396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5
    [5]
    肖正杰,田庆刚,海尔汗. 胃癌患者术后生存时间的影响因素分析[J]. 中国普外基础与临床杂志,2021,28(7):4.
    [6]
    Bray F,Ferlay J,Soerjomataram I,et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2018,68(6):394-424. doi: 10.3322/caac.21492
    [7]
    Fan X,Qin X,Zhang Y,et al. Screening for gastric cancer in China: Advances,challenges and visions[J]. Chin J Cancer Res,2021,33(2):168-180. doi: 10.21147/j.issn.1000-9604.2021.02.05
    [8]
    杨之洵,郑荣寿,张思维,等. 中国胃癌发病趋势及预测[J]. 中国肿瘤,2019,28(5):321-326.
    [9]
    高梓茗,徐惠绵. 胃癌精准外科治疗的研究新进展[J]. 中华医学信息导报,2021,36(1):7-8. doi: 10.3760/cma.j.issn.1000-8039.2021.01.106
    [10]
    武爱文,季加孚. 胃癌分期与临床诊治相关性[J]. 中国医学前沿杂志,2012,(5):3.
    [11]
    Youn G J,Chung W C. Micrometastasis in Gastric Cancer[J]. Korean J Gastroenterol,2017,69(5):270-277. doi: 10.4166/kjg.2017.69.5.270
    [12]
    姜晓东. 根治性手术与姑息性手术对老年胃癌患者的临床疗效及术后创伤的影响分析[J]. 国际医药卫生导报,2019,25(18):3. doi: 10.3760/cma.j.issn.1007-1245.2019.18.036
    [13]
    包永兴,惠周光. 术后放疗在接受新辅助化疗联合手术切除的非小细胞肺癌的应用进展[J]. 中华放射肿瘤学杂志,2022,31(1):7.
    [14]
    周希山, 郭俊, 杨静, 等. 恩度与化疗联合治疗多种晚期恶性肿瘤的临床观察. 世界最新医学信息文摘, 2017, 17(5): 1.
    [15]
    Emoto S,Ishigami H,Yamashita H,Yamaguchi H,Kaisaki S,Kitayama J. Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination[J]. Gastric Cancer,2012,15(2):154-61. doi: 10.1007/s10120-011-0091-8
    [16]
    Wang J,Wang X,Yu F,et al. Combined detection of preoperative serum CEA,CA19-9 and CA242 improve prognostic prediction of surgically treated colorectal cancer patients[J]. Int J Clin Exp Pathol,2015,8(11):14853-14863.
    [17]
    Liu X,Qiu H,Liu J,et al. Combined preoperative concentrations of CEA,CA 19-9,and 72-4 for predicting outcomes in patients with gastric cancer after curative resection[J]. Oncotarget,2016,7(23):35446-35453. doi: 10.18632/oncotarget.9060
    [18]
    Klump K E,Mc Ginnis J F. The role of reactive oxygen species in ocular malignancy[J]. Adv Exp Med Biol,2014,801(7):655-659.
    [19]
    Lin J X,Wang Z K,Huang Y Q,et al. Dynamic Changes in Pre- and Postoperative Levels of Inflammatory Markers and Their Effects on the Prognosis of Patients with Gastric Cancer[J]. J Gastrointest Surg,2021,25(2):387-396. doi: 10.1007/s11605-020-04523-8
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