Clinicopathological Features and Prognosis of Mucinous Breast Carcinoma

Ting GAO; Sheng HUANG; Rong GUO; Dedian CHEN

doi:10.12259/j.issn.2095-610X.S20230306

Volume 44 Issue 3

Mar. 2023

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Ting GAO, Sheng HUANG, Rong GUO, Dedian CHEN. Clinicopathological Features and Prognosis of Mucinous Breast Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20230306

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Ting GAO, Sheng HUANG, Rong GUO, Dedian CHEN. Clinicopathological Features and Prognosis of Mucinous Breast Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20230306

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Clinicopathological Features and Prognosis of Mucinous Breast Carcinoma

doi: 10.12259/j.issn.2095-610X.S20230306

The Second Department of Breast Surgery，The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan，Kunming Yunnan 650118，China

Received Date: 2022-11-14
Available Online: 2023-03-02
Publish Date: 2023-03-25

Abstract

Abstract

Objective To investigate the clinicopathological characteristics of mucinous breast carcinoma （MuBC） and its relationship with prognosis, so as to provide reference for patients to make a personalized treatment plan. Methods The clinical and pathological data of 139 MuBC patients admitted to Yunnan Cancer Hospital from January 2008 to September 2021 were retrospectively collected. They were divided into pure mucinous breast carcinoma （PMuBC） group （n = 76） and mixed mucinous breast carcinoma （MMuBC） group （n = 63）, and compared between two groups. COX proportional hazards regression model was used to determine the prognostic factors of MuBC.Kaplan-Meier and log-rank tests were used for survival analysis. Results The 10-year overall survival rate of PMuBC group was higher than that of MMuBC group （98.6% vs 83.7%, P = 0.019）. The proportion of uninvolved lymph nodes （81.6% vs 47.6%, P < 0.001） in PMuBC group was higher than those in MMuBC group.COX multivariate analysis showed that tumor size was stage T1 （P = 0.005）, tumor size was stage T2 （P = 0.006） and positive PR （P = 0.033） were prognostic protective factors. Lymph node involvement reached stage N3 （P = 0.052） and distant metastasis （P = 0.025） are prognostic risk factors. Conclusions Tumor size, lymph node metastasis, distant metastasis and PR status are independent prognostic factors for MuBC. Compared with MMuBC, PMuBC has lower lymph node metastasis rate, higher positive rate of PR and better prognosis.
- Mucinous breast carcinoma,
- Pathological feature,
- Prognosis,
- Survival

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References(27)

References

[1]	Sung H,Ferlay J,Siegel R L,et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2021,71(3):209-249. doi: 10.3322/caac.21660
[2]	Leil,Yu X,Chen B,et al. Clinicopathological characteristics of mucinous breast cancer: A retrospective analysis of a 10-Year study[J]. PLoS One,2016,11(5):e0155132. doi: 10.1371/journal.pone.0155132
[3]	Budzik M P,Fudalej M M,Badowska-Kozakiewicz A M. Histopathological analysis of mucinous breast cancer subtypes and comparison with invasive carcinoma of no special type[J]. Sci Rep,2021,11(1):5770. doi: 10.1038/s41598-021-85309-z
[4]	Gannon L M,Cotter M B,Quinn C M. The classification of invasive carcinoma of the breast[J]. Expert Rev Anticancer Ther,2013,13(8):941-954. doi: 10.1586/14737140.2013.820577
[5]	Marrazzo E,Frusone F,Milana F,et al. Mucinous breast cancer: A narrative review of the literature and a retrospective tertiary single-centre analysis[J]. Breast,2020,49:87-92. doi: 10.1016/j.breast.2019.11.002
[6]	Li C I. Risk of mortality by histologic type of breast cancer in the United States[J]. Horm Cancer,2010,1(3):156-165. doi: 10.1007/s12672-010-0016-8
[7]	Hu T,Huang J,Fang K. Overall survival in patients with mucinous carcinoma of breast:A population-based study[J]. Int J Gen Med,2021,14:9991-10001. doi: 10.2147/IJGM.S343137
[8]	Cserni G. Histological type and typing of breast carcinomas and the WHO classification changes over time[J]. Pathologica,2020,112(1):25-41. doi: 10.32074/1591-951X-1-20
[9]	Castaneda C A,Andrés E,Barcena C,et al. Behaviour of breast cancer molecular subtypes through tumour progression[J]. Clin Transl Oncol,2012,14(6):481-485. doi: 10.1007/s12094-012-0827-x
[10]	Rakha E A,Tse G M,Quinn C M. An update on the pathological classification of breast cancer[J]. Histopathology,2023,82(1):5-16. doi: 10.1155/2022/1230812
[11]	Sas-KorczyŃska B,MituŚ J,Stelmach A,et al. Mucinous breast cancer - clinical characteristics and treatment results in patients treated at the Oncology Centre in Kraków between 1952 and 2002[J]. Contemp Oncol (Pozn),2014,18(2):120-123.
[12]	西部多中心临床合作流行病学调查组. 我国乳腺癌发病年龄前移 [J]. 中国肿瘤临床与康复, 2015, 22（10）: 1274.
[13]	Tseng H S,Lin C,Chan S E,et al. Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwan residents women[J]. World J Surg Oncol,2013,11:139. doi: 10.1186/1477-7819-11-139
[14]	Cao A Y,He M,Liu Z B,et al. Outcome of pure mucinous breast carcinoma compared to infiltrating ductal carcinoma: a population-based study from China[J]. Annals of Surgical Oncology,2012,19(9):3019-3027. doi: 10.1245/s10434-012-2322-6
[15]	Pan B,Yao R,Shi J,et al. Prognosis of subtypes of the mucinous breast carcinoma in Chinese women: a population-based study of 32-year experience (1983-2014)[J]. Oncotarget,2016,7(25):38864-38875. doi: 10.18632/oncotarget.8778
[16]	Zhang M,Teng X D,Guo X X,et al. Clinicopathological characteristics and prognosis of mucinous breast carcinoma[J]. J Cancer Res Clin Oncol,2014,140(2):265-2659. doi: 10.1007/s00432-013-1559-1
[17]	Skotnicki P,Sas-Korczynska B,Strzepek L,et al. Pure and mixed mucinous carcinoma of the breast: A comparison of clinical outcomes and treatment results[J]. The Breast Journal,2016,22(5):529-534. doi: 10.1111/tbj.12621
[18]	Yu P,Liu P,Zou Y,et al. Breast-conserving therapy shows better prognosis in mucinous breast carcinoma compared with mastectomy: A SEER population-based study[J]. Cancer Med,2020,9(15):5381-5391. doi: 10.1002/cam4.3202
[19]	Di Saverio S,Gutierrez J,Avisar E. A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma[J]. Breast Cancer Res Treat,2008,111(3):541-547. doi: 10.1007/s10549-007-9809-z
[20]	Zhou X,Zheng Z,Li Y,et al. The clinical features and prognosis of patients with mucinous breast carcinoma compared with those with infiltrating ductal carcinoma: a population-based study[J]. BMC Cancer,2021,21(1):536. doi: 10.1186/s12885-021-08262-0
[21]	Wu S L,Gai J D,Yu X M,et al. A novel nomogram and risk classification system for predicting lymph node metastasis of breast mucinous carcinoma:A SEER-based study[J]. Cancer Med,2022,11(24):4767-4783.
[22]	Komenaka I K,El-Tameer M B,Troxel A,et al. Pure mucinous carcinoma of the breast[J]. The American Journal of Surgery,2004,187(4):528-532. doi: 10.1016/j.amjsurg.2003.12.039
[23]	Barkley C R,Ligibel J A,Wong J S,et al. Mucinous breast carcinoma: a large contemporary series[J]. American Journal of Surgery,2008,196(4):549-551. doi: 10.1016/j.amjsurg.2008.06.013
[24]	Gwark S C,Lee H S,Lee Y,et al. Clinical implication of HER2 status in hormone receptor-positive mucinous breast cancer[J]. Annals of Surgical Oncology,2019,26(7):2166-2174. doi: 10.1245/s10434-019-07332-9
[25]	Kangleon-Tan H L,Sim J,You J Y,et al. Omission of chemotherapy for hormone receptor-positive and human epidermal growth factor receptor 2-negative breast cancer:patterns of treatment and outcomes from the Korean Breast Cancer Society Registry[J]. Ann Surg Treat Res,2022,103(6):313-322.
[26]	Kim H S,Lee J U,Yoo T K,et al. Omission of chemotherapy for the treatment of mucinous breast cancer: A nationwide study from the Korean breast cancer society[J]. J Breast Cancer,2019,22(4):599-612. doi: 10.4048/jbc.2019.22.e46
[27]	Chen R,Wang Y,Li T,et al. Oncotype DX 21-gene test has a low recurrence score in both pure and mixed mucinous breast carcinoma[J]. Oncol Lett,2021,22(5):771. doi: 10.3892/ol.2021.13032

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