Volume 44 Issue 3
Mar.  2023
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Article Contents
Jie LI, Yuan HE, Chunyan WU, Bin SHAN, Rui ZHENG, Zhifu GUAN, Baojun REN, Chunxia SHI, Youquan ZHOU, Hanyu LIU, Mi ZHANG, Yanming KANG, Guibo SONG. Distribution and Drug Resistance Analysis of Bacteria in Sterile Body Fluids in Yunnan from 2017 to 2021[J]. Journal of Kunming Medical University, 2023, 44(3): 61-67. doi: 10.12259/j.issn.2095-610X.S20230309
Citation: Jie LI, Yuan HE, Chunyan WU, Bin SHAN, Rui ZHENG, Zhifu GUAN, Baojun REN, Chunxia SHI, Youquan ZHOU, Hanyu LIU, Mi ZHANG, Yanming KANG, Guibo SONG. Distribution and Drug Resistance Analysis of Bacteria in Sterile Body Fluids in Yunnan from 2017 to 2021[J]. Journal of Kunming Medical University, 2023, 44(3): 61-67. doi: 10.12259/j.issn.2095-610X.S20230309

Distribution and Drug Resistance Analysis of Bacteria in Sterile Body Fluids in Yunnan from 2017 to 2021

doi: 10.12259/j.issn.2095-610X.S20230309
  • Received Date: 2022-11-14
    Available Online: 2023-03-02
  • Publish Date: 2023-03-25
  •   Objective  To explore the bacterial distribution and drug resistance of sterile body fluid specimens (excluding blood) in nine tertiary general hospitals in Yunnan Province from 2017-2021, and to provide a reference basis for the rational clinical use of antibiotics in the region.   Methods  Repeated strains from the same patients were excluded, and drug sensitivity tests were performed by instrumental method or paper method, and the results were interpreted according to the 2021 CLSI standard.   Results  Ascites was the specimen type with the highest strain isolation rate, accounting for 32.7%. A total of 5305 strains were isolated from all specimens, with Gram-positive bacteria accounting for 53.3%, predominantly Staphylococcus epidermidis, and Gram-negative bacteria accounting for 46.7%, predominantly Escherichia coli. Methicillin-resistant coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus were comparable in both cases and should not be underestimated. Enterococcus faecalis showed a decreasing trend of resistance to commonly used antimicrobials. The resistance rates of Klebsiella pneumoniae to meropenem and imipenem were 35.6% and 40.3%, respectively, both of which were higher than the 2021 CHINET level, and the resistance rates showed a trend of increasing year by year. Acinetobacter baumannii was highly resistant to most antibiotics, especially to carbapenems with a resistance rate of 82%.   Conclusion  The source of pathogenic bacteria in sterile body fluid is extensive, and the form of carbapenem resistance among different genera is severe. It is still necessary to focus on monitoring the third-generation cephalosporin-resistant Enterobacteriaceae and carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii.
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