Clinical Significance of a Marker of Thrombin Activity-fibrin Monomer after Surgery

Jinxi YUE; Linjun WAN; Ruiling ZHANG; Xiaoran ZHANG; Ouya LIU; Xiaofan YU; Qingqing HUANG; Zongfang REN

doi:10.12259/j.issn.2095-610X.S20230325

Volume 44 Issue 3

Mar. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(3): 87-91

Jinxi YUE, Linjun WAN, Ruiling ZHANG, Xiaoran ZHANG, Ouya LIU, Xiaofan YU, Qingqing HUANG, Zongfang REN. Clinical Significance of a Marker of Thrombin Activity-fibrin Monomer after Surgery[J]. Journal of Kunming Medical University, 2023, 44(3): 87-91. doi: 10.12259/j.issn.2095-610X.S20230325

Citation:

Jinxi YUE, Linjun WAN, Ruiling ZHANG, Xiaoran ZHANG, Ouya LIU, Xiaofan YU, Qingqing HUANG, Zongfang REN. Clinical Significance of a Marker of Thrombin Activity-fibrin Monomer after Surgery[J]. Journal of Kunming Medical University, 2023, 44(3): 87-91. doi: 10.12259/j.issn.2095-610X.S20230325

Citation:

Jinxi YUE, Linjun WAN, Ruiling ZHANG, Xiaoran ZHANG, Ouya LIU, Xiaofan YU, Qingqing HUANG, Zongfang REN. Clinical Significance of a Marker of Thrombin Activity-fibrin Monomer after Surgery[J]. Journal of Kunming Medical University, 2023, 44(3): 87-91. doi: 10.12259/j.issn.2095-610X.S20230325

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Clinical Significance of a Marker of Thrombin Activity-fibrin Monomer after Surgery

doi: 10.12259/j.issn.2095-610X.S20230325

Dept. of Critical Care Medicine，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2022-10-08
Available Online: 2023-03-02
Publish Date: 2023-03-25

Abstract

Abstract

Objective To investigate the clinical significance and monitoring value of fibrin monomer （FM）after surgery. Methods A total of 93 patients after surgery admitted to the Department of Critical Care Medicine, the Second Affiliated Hospital of Kunming Medical University from December 2021 to May 2022 were retrospectively analyzed. Plasma fibrin monomer （FM）, antithrombinⅢ （AT-Ⅲ）, von willebrand factor （vWF） and fibrin degradation products （DD ） were collected before operation （T₀）, on the day after operation （T₁） and 24 hours after operation （T₂）. According to the normal reference range of FM value, patients were divided into normal group, low level group, medium level group and high level group. The clinical data of patients were statistically analyzed, the influencing factors of FM were analyzed by ordinal logistic regression, the correlation between vWF, AT-Ⅲ, DD dimer and FM was analyzed by multivariate regression, and the correlation between Fib and FM was analyzed by univariate regression. Results （1） A total of 93 patients were enrolled, with an average age of 59±13 years, including 49 males and 44 females. Of these, 61 were malignant （66%） and 32 were non-tumor （34%）. （2） The patients were divided into normal group （≤5 μg/mL, n = 9 （9.7%）, FM （4.32±1.07） μg/mL. The low level group was 6-54 μg/mL, 39 cases （41.9%）, FM （20.67±13.25） μg/mL; Medium level group （55～103 μg/mL, 11 cases （11.8%）, FM （73.96±13.38） μg/mL; High level group ≥104 μg/mL, 34 cases （36.6%）, FM （172.30±26.78） μg/mL.Analysis of variance （ANOVA） showed that the difference between the normal level group and the low level group was statistically significant （P < 0.05）, and the difference between the other groups was significant （P < 0.0010.00）. Ordinal logistic regression analysis showed that blood loss volume, vWF, primary disease, age and gender had no significant effect on fibrin monomer （FM）（P > 0.05）. （3） Bivariate correlation analysis showed that FM was not correlated with Fib at T₀ and T₁, but was negatively correlated with Fib at T₂ （r = -0.258, P < 0.05）. DD at T₂ was positively correlated with FM （r = 0.536, P = 0.000）. （4） The plasma fibrin monomer （FM） concentration of patients with liver malignant tumor after surgery （76.4 μg/mL） was significantly higher than that of patients with gastrointestinal tumor after surgery （25.7 μg/mL）. DunnettT3 test showed that the difference was statistically significant （P < 0.05）. Conclusions Monitoring of thrombin activation marker fibrin monomer （FM） in patients after surgery has certain clinical significance, which is expected to be an early marker for predicting thrombosis or guiding anticoagulant therapy. A large amount of thrombin activation after surgery can consume fibrinogen （Fib）, and attention should be paid to the concentration of fibrinogen to avoid postoperative bleeding.
- Fibrin monomer,
- Thrombin,
- Markers,
- Postoperative surgery

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