Value of cMyBP-C in Clinical Diagnosis of Acute Myocardial Infarction

Xiaodong ZHU; Yanlong LIU; Xu ZHOU; Hailong DAI; Xiaolong YIN

doi:10.12259/j.issn.2095-610X.S20230328

Volume 44 Issue 3

Mar. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(3): 97-102

Xiaodong ZHU, Yanlong LIU, Xu ZHOU, Hailong DAI, Xiaolong YIN. Value of cMyBP-C in Clinical Diagnosis of Acute Myocardial Infarction[J]. Journal of Kunming Medical University, 2023, 44(3): 97-102. doi: 10.12259/j.issn.2095-610X.S20230328

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Xiaodong ZHU, Yanlong LIU, Xu ZHOU, Hailong DAI, Xiaolong YIN. Value of cMyBP-C in Clinical Diagnosis of Acute Myocardial Infarction[J]. Journal of Kunming Medical University, 2023, 44(3): 97-102. doi: 10.12259/j.issn.2095-610X.S20230328

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Value of cMyBP-C in Clinical Diagnosis of Acute Myocardial Infarction

doi: 10.12259/j.issn.2095-610X.S20230328

Dept .of Cardiology/Key Laboratory of Cardiovascular Disease of Yunnan Province/Clinical Medicine Center for Cardiovascular Disease of Yunnan Province，Yan’an Affiliated Hospital of Kunming Medical University，KunmingYunnan 650051，China

Received Date: 2022-11-09
Available Online: 2023-03-02
Publish Date: 2023-03-25

Abstract

Abstract

Objective To investigate the potential of cardiac myosin binding protein-C （cMyBP-C） as a novel marker of myocardial infarction by detecting the concentration of cardiac myosin binding protein-C （cMyBP-C） in venous blood of patients with acute myocardial infarction. Methods A total of 120 patients with chest pain as the first symptom and within 24 hours of the onset of chest pain were collected and divided into three groups, including 40 patients with acute myocardial infarction （group A）, 20 patients with angina pectoris （group B）, and 60 patients with non-cardiogenic chest pain （Group C）; 30 healthy volunteers （Group D） were selected as the control group. All patients with chest pain were immediately drawn elbow venous blood after admission, and 3 hours after admission. The control group was immediately drawn venous blood once after admission. The concentrations of cMyBP-C and cTnI in each sample were measured by ELISA and chemiluminescence. Results （1） The concentrations of cMyBP-C and cTnI in group A were significantly higher than those in groups B, C and D （P < 0.05）; （2） In group A, the onset time of 9 patients was less than 4h. The concentration of cMyBP-C measured by blood sampling immediately after admission was significantly higher than that in Group D. the concentration of cTnI measured by blood sampling immediately after admission did not increase significantly, and the difference was statistically significant （P < 0.05）; In group A, 35 patients underwent emergency PCI immediately after admission. The concentration of cMyBP-C measured after operation （3h after admission） was significantly lower than that before operation, and the concentration of cTnI after operation was higher than that before operation. The difference was statistically significant （P < 0.05）; （3） There was a positive correlation between cMyBP-C and cTnI concentrations in groups a, B and C. the AUC value of ROC curve of cMyBP-C in diagnosing acute myocardial infarction with onset time less than 24 hours was 0.954, the sensitivity was 92.5%, and the specificity was 90.0%. Conclusion cMyBP-C, similar to cTnI, has the potential to be used as a biomarker for early diagnosis of myocardial infarction and as an early evaluation index for the condition and surgical effect after PCI.
- Cardiac myosin binding protein C,
- Troponin I,
- Acute myocardial infarction,
- Biomarkers

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References(25)

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