Study on Fluencing Factors of Colorectal Polyp Canceration

Na KONG; Yinglei MIAO; Liping HE; Junkun NIU; Xiangqian DONG; Fan ZHANG

doi:10.12259/j.issn.2095-610X.S20230401

Volume 44 Issue 4

Apr. 2023

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Na KONG, Yinglei MIAO, Liping HE, Junkun NIU, Xiangqian DONG, Fan ZHANG. Study on Fluencing Factors of Colorectal Polyp Canceration[J]. Journal of Kunming Medical University, 2023, 44(4): 53-61. doi: 10.12259/j.issn.2095-610X.S20230401

Citation:

Na KONG, Yinglei MIAO, Liping HE, Junkun NIU, Xiangqian DONG, Fan ZHANG. Study on Fluencing Factors of Colorectal Polyp Canceration[J]. Journal of Kunming Medical University, 2023, 44(4): 53-61. doi: 10.12259/j.issn.2095-610X.S20230401

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Study on Fluencing Factors of Colorectal Polyp Canceration

doi: 10.12259/j.issn.2095-610X.S20230401

1.
Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
School of Public Health，Kunming Medical University，Kunming Yunnan，650500
3.
Dept. of Gastroenterology，The 3rd People’s Hospital of Yunnan Province，Kunming Yunnan 650200，China

Received Date: 2023-01-07
Available Online: 2023-04-24
Publish Date: 2023-04-25

Abstract

Abstract

Objective To investigate the influencing factors of colorectal polyp canceration, to improve the early diagnosis and treatment of colorectal cancer, and to reduce the incidence. Methods Patients diagnosed with intestinal polyps during hospitalization in the Department of Gastroenterology, the First Affiliated Hospital of Kunming Medical University from January 2020 to December 2022 were retrospectively selected. Clinical data including gender, age, height, weight, history of smoking, drinking, diabetes and hypertension, family and personal history of bowel cancer, the position, shape, size, number and pathological type of polyps were collected and analyzed. Results A total of 4700 patients were investigated and cancer occurred in 665 cases, with a cancer rate of 14.1%. There was no significant difference in the rate of intestinal polyp canceration in gender, BMI, diabetes mellitus, alcohol consumption or family history of bowel cancer groups （P > 0.05）. There were significant differences in intestinal polyp canceration rate among patients in different age groups, hypertension, smoking, history of bowel cancer, different polyp sites, different polyp morphology, different polyp surface conditions, different number of polyps （single or multiple）, and different polyp diameters （P < 0.05）. The results of unconditioned binary Logistic regression analysis showed that age, hypertension, smoking, polyp location, morphology, surface and size were the factors affecting the carcinogenesis of intestinal polyps （P < 0.05）. When analyzing the relationship between pathological types and canceration, 5 cases of villous adenoma among 4700 patients investigated were too few to be included in the analysis, but the number of cases was too small to be included in the analysis. 69 cases were found to be “adenocarcinoma”, and the pathological types before canceration could not be identified, so they were not included in the analysis. Finally, 4, 626 patients were included in the analysis. The cancer rate of different pathological types was statistically significant （P < 0.05）. Pair-wise comparison showed that there were differences between the following groups （P < 0.001） : the cancer rate of tubulovillous adenoma was the highest （42.0%）, followed by tubulovillous adenoma （6.1%）, and the lowest non-neoplastic polyps （0%）. Conclusion The most common pathological type of large intestine polyp is tubular adenoma, and the risk of polyp canceration increases with the increase of villi. The endoscopic characteristics of high-risk polyps include locating at rectal and sigmoid colon, lobed surface, type Ⅱ and Ⅲ of Polyp field classification, large diameter polyps. The risk of colorectal polyp canceration was positively correlated with age, and the risk of polyp canceration increased with age, especially over 60 years old. Smoking and high blood pressure are the risk factors for intestinal polyp canceration.
- Large intestine polyp,
- Canceration,
- Influencing factors

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References(20)

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