To Investigate the Application Effect of Dapagliflozin in Elderly Patients with HFpEF and Type 2 Diabetes Mellitus and Its Effect on Inflammatory Factors

Jianpei SU; Miyu HE; Yongli WANG; Qi WU; Weimeng TIAN; Jin LI; Bijuan LIANG

doi:10.12259/j.issn.2095-610X.S20230405

Volume 44 Issue 4

Apr. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(4): 112-116

Jianpei SU, Miyu HE, Yongli WANG, Qi WU, Weimeng TIAN, Jin LI, Bijuan LIANG. To Investigate the Application Effect of Dapagliflozin in Elderly Patients with HFpEF and Type 2 Diabetes Mellitus and Its Effect on Inflammatory Factors[J]. Journal of Kunming Medical University, 2023, 44(4): 112-116. doi: 10.12259/j.issn.2095-610X.S20230405

Citation:

Jianpei SU, Miyu HE, Yongli WANG, Qi WU, Weimeng TIAN, Jin LI, Bijuan LIANG. To Investigate the Application Effect of Dapagliflozin in Elderly Patients with HFpEF and Type 2 Diabetes Mellitus and Its Effect on Inflammatory Factors[J]. Journal of Kunming Medical University, 2023, 44(4): 112-116. doi: 10.12259/j.issn.2095-610X.S20230405

Citation:

Jianpei SU, Miyu HE, Yongli WANG, Qi WU, Weimeng TIAN, Jin LI, Bijuan LIANG. To Investigate the Application Effect of Dapagliflozin in Elderly Patients with HFpEF and Type 2 Diabetes Mellitus and Its Effect on Inflammatory Factors[J]. Journal of Kunming Medical University, 2023, 44(4): 112-116. doi: 10.12259/j.issn.2095-610X.S20230405

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To Investigate the Application Effect of Dapagliflozin in Elderly Patients with HFpEF and Type 2 Diabetes Mellitus and Its Effect on Inflammatory Factors

doi: 10.12259/j.issn.2095-610X.S20230405

1.
Dept. of Geriatrics
2.
Dept. of Comprehensive Geriatrics，The 2nd People’s Hospital of Kunming，Kunming Yunnan 650204，China

Received Date: 2023-01-18
Available Online: 2023-04-12
Publish Date: 2023-04-25

Abstract

Abstract

Objective To investigate the efficacy of dapagliflozin in elderly heart failure patients with preserved ejection fraction （HFpEF） complicated with type 2 diabetes mellitus （T2DM） and its effect on inflammatory factors. Methods From March 2021 to September 2022, 64 patients with HFpEF and type 2 diabetes in the Second People’s Hospital of Kunming were randomly divided into two groups. The control group was treated with metformin, and the study group was treated with dapagliflozin. The indexes of cardiac ultrasound, changes in exercise endurance, inflammatory factors, N-terminal pro-brain natriuretic peptide levels, and adverse reactions were studied. Results After 3 months and 6 months of treatment, the LVEF and 6 min walking distance indexes of the two groups were significantly higher than those before treatment （P < 0.05）, and the LVEDD and E/e′ indexes were significantly lower than those before treatment （P < 0.05）. After 3 months and 6 months of treatment, LVEF and 6 min walking distance indexes of the study group were significantly higher than those of the control group （P < 0.05）, LVEDD and E/e′ indexes were significantly lower than those of the control group, and the differences were statistically significant （P < 0.05）. The hs-CRP, TNF-α and NT-proBNP of the two groups at 3 months and 6 months after treatment significantly were lower than those before treatment （P < 0.05）. The hs-CRP, TNF-α and NT-proBNP in the study group were significantly lower than those in the control group at 3 months and 6 months after treatment （P < 0.05）. There were no adverse reactions such as allergic rash, hypotension, acute renal injury, and hyperkalemia in two groups during treatment, and there were no statistically significant differences in the incidence of adverse reactions such as gastrointestinal reaction, urinary system infection, and hypoglycemia between the two groups （P > 0.05）. Conclusion In the treatment of elderly HFpEF patients with type 2 diabetes mellitus, compared with metformin dapagliflozin can improve cardiac function and exercise endurance , without significant adverse reactions.
- Type 2 diabetes mellitus,
- Ejection fraction retention heart failure,
- Sports endurance,
- Left ventricular ejection fraction

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References(17)

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