The Value of Urinary AD7c-NTP and P300 in the Diagnosis of AD-derived MCI

Xiaoyu TUO; Chao LI; Liping GUO; Huajun ZHAO

doi:10.12259/j.issn.2095-610X.S20230407

Volume 44 Issue 4

Apr. 2023

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Xiaoyu TUO, Chao LI, Liping GUO, Huajun ZHAO. The Value of Urinary AD7c-NTP and P300 in the Diagnosis of AD-derived MCI[J]. Journal of Kunming Medical University, 2023, 44(4): 62-68. doi: 10.12259/j.issn.2095-610X.S20230407

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Xiaoyu TUO, Chao LI, Liping GUO, Huajun ZHAO. The Value of Urinary AD7c-NTP and P300 in the Diagnosis of AD-derived MCI[J]. Journal of Kunming Medical University, 2023, 44(4): 62-68. doi: 10.12259/j.issn.2095-610X.S20230407

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The Value of Urinary AD7c-NTP and P300 in the Diagnosis of AD-derived MCI

doi: 10.12259/j.issn.2095-610X.S20230407

1.
Dept. of Pathology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Mental Health Center affiliated to Kunming Medical University，KunmingYunnan 650224，China

Received Date: 2023-01-28
Available Online: 2023-04-24
Publish Date: 2023-04-25

Abstract

Abstract

Objective To investigate the value of urine AD7c-NTP level test combined with ERP P300 in the diagnosis of AD-derived mild cognitive impairment （MCI）. Methods 78 healthy subjects in control group, 72 in MCI group and 108 in AD group were selected and assessed by MMSE and ADL scale. AD7c-NTP levels in urine of each group were determined by enzyme-linked immunosoradsorption method （ELLSA） and event-related potential （ERP） P300 tests were performed in each group. Results Urine AD7c-NTP and latent time of ERP P300 were siginificantly different among healthy control group, MCI group and AD group （P < 0.05）. Pair-wise comparison showed that urine AD7c-NTP and latent time of ERP P300 were different among healthy control and MCI group, MCI group and AD group, and healthy control and AD group （P < 0.05）. Conclusion The elevated AD7c-NTP in urine in this study indicated the neuronal damage from mild cognitive impairment （MCI） to AD. The abnormal P300 indicates the impaired brain function, and the two have the same pathophysiological process. These results showed that the detection rate of early AD can be effectively improved through the combination of laboratory and functional examination, which can be used as an important reference index for early diagnosis and treatment of AD, as well as a reference basis for screening MCI and early AD.
- Dementia caused by Alzheimer's disease,
- Mild cognitive impairment,
- Urinary AD7c-NTP,
- P300

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References(24)

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