Clinical Data Analysis of 108 Patients with Primary Hyperparathyroidism

Qingxia YANG; Changrong WU; Juanzhang LUO; Wei WANG; Yahong WANG; Ruimei SUN

doi:10.12259/j.issn.2095-610X.S20230411

Volume 44 Issue 4

Apr. 2023

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Qingxia YANG, Changrong WU, Juanzhang LUO, Wei WANG, Yahong WANG, Ruimei SUN. Clinical Data Analysis of 108 Patients with Primary Hyperparathyroidism[J]. Journal of Kunming Medical University, 2023, 44(4): 75-81. doi: 10.12259/j.issn.2095-610X.S20230411

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Qingxia YANG, Changrong WU, Juanzhang LUO, Wei WANG, Yahong WANG, Ruimei SUN. Clinical Data Analysis of 108 Patients with Primary Hyperparathyroidism[J]. Journal of Kunming Medical University, 2023, 44(4): 75-81. doi: 10.12259/j.issn.2095-610X.S20230411

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Clinical Data Analysis of 108 Patients with Primary Hyperparathyroidism

doi: 10.12259/j.issn.2095-610X.S20230411

1.
The 2nd Dept. of Head and Neck Surgery，Yunnan Cancer Hospital/The 3rd Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center，Kunming Yunnan 650118
2.
The Dept. of Tumor Surgery，The Northeast Yunnan Regional Central Hospital of Yunnan Province，Zhaotong Yunnan 657000，China

Received Date: 2022-12-26
Publish Date: 2023-04-25

Abstract

Abstract

Objective To analyze the clinical data of patients with PHPT in Yunnan Cancer Hospital, to explore the clinical characteristics, and improve the understanding, diagnosis and treatment of this disease. Methods The clinical data of 108 PHPT patients admitted to Yunnan Cancer Hospital from January 2012 to December 2021 were retrospectively analyzed, and the clinical differences between symptomatic PHPT and asymptomatic PHPT were compared. Results Among 108 patients with PHPT, 58 （53.7%） were in the symptomatic group and 50 （46.3%） were in the asymptomatic group. The age of onset was earlier in males than in females, the difference was statistically significant （P = 0.001）. The proportion of men in the symptom group was higher than that of women, the difference was statistically significant （P = 0.002）. Patients of sPHPT had an earlier onset age （P = 0.001） and longer disease duration than those of aPHPT （P < 0.001）. PHPT visits were increasing, and the increasing trend was more pronounced in aPHPT after 2018 than in sPHPT. Impairment of the skeletal system （84.5%）was the most common patient in the symptomatic group, while patients in the asymptomatic group often had unexpected findings of blood calcium elevation or suspicious lesions found by neck ultrasound.The accuracy of 99mTc-MIBI lesion localization （94.44%）is higher than neck ultrasound （78.7%）or neck contrast-enhanced CT, but 99mTc-MIBI combined with neck ultrasound examination may improve the accuracy of preoperative localization （97.22%）. Skeletal system damage was the most common in sPHPT （84.5%）, while in aPHPT group, patients were more likely to seek medical treatment due to accidental discovery of elevated blood calcium or suspicious lesions found by cervical ultrasound. The accuracy of 99mTc-MIBI lesion localization （94.44%） was higher than that of cervical ultrasound （78.7%） or cervical contrast CT （78.7%）, but 99mTc-MIBI combined with cervical ultrasound could improve the accuracy of preoperative localization （97.22%）. Conclusion There is an increasing trend for PHPT visits. In recent years, the increase trend of aPHPT patients is more obvious than that of sPHPT; Male patients were more severely ill than female patients and had an earlier onset in PHPT. The localization accuracy of 99mTc-MIBI is the highest, and the combination of neck ultrasound can improve the localization accuracy.
- Primary hyperparathyroidism,
- Asymptomatic diseases,
- Clinical features,
- Parathyroidectomy

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