Screening of Congenital Heart Disease at Different Time in Neonates in Anning Area by Auscultation Combined with Pulse Oximetry

Jianhong XU; Zhengmin REN; Yanjiao ZHAO; Shiyun LI; Ruijuan ZHANG; Faguo ZHANG

doi:10.12259/j.issn.2095-610X.S20230425

Volume 44 Issue 4

Apr. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(4): 128-132

Jianhong XU, Zhengmin REN, Yanjiao ZHAO, Shiyun LI, Ruijuan ZHANG, Faguo ZHANG. Screening of Congenital Heart Disease at Different Time in Neonates in Anning Area by Auscultation Combined with Pulse Oximetry[J]. Journal of Kunming Medical University, 2023, 44(4): 128-132. doi: 10.12259/j.issn.2095-610X.S20230425

Citation:

Jianhong XU, Zhengmin REN, Yanjiao ZHAO, Shiyun LI, Ruijuan ZHANG, Faguo ZHANG. Screening of Congenital Heart Disease at Different Time in Neonates in Anning Area by Auscultation Combined with Pulse Oximetry[J]. Journal of Kunming Medical University, 2023, 44(4): 128-132. doi: 10.12259/j.issn.2095-610X.S20230425

Citation:

Jianhong XU, Zhengmin REN, Yanjiao ZHAO, Shiyun LI, Ruijuan ZHANG, Faguo ZHANG. Screening of Congenital Heart Disease at Different Time in Neonates in Anning Area by Auscultation Combined with Pulse Oximetry[J]. Journal of Kunming Medical University, 2023, 44(4): 128-132. doi: 10.12259/j.issn.2095-610X.S20230425

PDF( 627 KB)

Screening of Congenital Heart Disease at Different Time in Neonates in Anning Area by Auscultation Combined with Pulse Oximetry

doi: 10.12259/j.issn.2095-610X.S20230425

1.
Dept. of Pediatrics，The 1st People’s Hospital of anning
2.
Dept. of Obstetrics and Gynecology
3.
Dept. of Medicical Administration
4.
Dept. of Neonatology
5.
Dept. of Ultrasound，Kunming Yunnan 650302，China

Received Date: 2022-12-19
Available Online: 2023-04-12
Publish Date: 2023-04-25

Abstract

Abstract

Objective To study the value of heart murmur auscultation （MUR） combined with pulse oximetry （POX） in the screening of congenital heart disease （CHD） at different time periods after birth in Anning area. Methods A total of 1833 newborns born in the obstetrics department and referred to the Department of Neonatology of Anning First People’s Hospital from June 2021 to November 2022 were selected as the study subjects. According to the age, the subjects were divided into 24-72 hours group （575 cases） and 2-4 weeks group （1258 cases）. The double-index method of heart murmur auscultation （MUR） combined with pulse oxygen saturation （POX） was used to screen CHD. The value of heart murmur auscultation combined with pulse oxygen saturation in screening CHD at different time points after birth was recorded. Results Among the 1833 neonates, 68 were diagnosed with CHD by echocardiography, with an incidence rate of 3.71%.The top three types of CHD were ventricular septal defect （23 cases, 33.82%）, atrial septal defect （22 cases, 32.35%）, and patent foramen ovale （16 cases, 23.53%）. The positive rate of heart murmur auscultation combined with pulse oxygen saturation detection in 24-72 hours group was 12.00%, and the missed diagnosis rate was 39.13%. The screening positive rate of 2-4 weeks group was 5.88%, and the missed diagnosis rate was 28.89%, Screening positive rate χ² = 2.474, missed diagnosis rate χ² = 3.441, P < 0.05. In 24-72 hours group, the sensitivity of heart murmur auscultation combined with pulse oxygen saturation detection was 60.87%, and the specificity was 90.04%, the accuracy was 88.87%, the false positive rate was 79.71%, the false negative rate was 1.78%, the positive predictive value was 20.29%, the negative predictive value was 98.22%, and the Youden index was 0.5089. The screening sensitivity, specificity, accuracy, false positive rate, false negative rate, positive predictive value, negative predictive value and Youden index of 2-4 weeks group were 71.11%, 96.54%, 95.63%, 56.76%, 1.10%, 43.24%, 98.90% and 0.6764, respectively;sensitivity χ² = 8.325, specificity χ² = 7.051, P < 0.05. Conclusion For CHD screening of newborns after birth, heart murmur auscultation （MUR） combined with pulse oxygen saturation （POX） has the highest accuracy and low rate of missed diagnosis at 2-4 weeks of screening time, which can improve the birth quality of newborns and play an important role in promoting neonatal eugenic and eugenic care in Anning area.
- Heart murmur auscultation,
- Pulse oximetry,
- Congenital heart disease,
- Newborn

FullText(HTML)

References(22)

References

[1]	邓润迪,张凤文. 介入治疗小儿先天性心脏病的围术期管理[J]. 中国循环杂志,2021,36(9):933-936.
[2]	胡晓静,马晓静,曾子倩,等. 应用脉搏血氧饱和度或/和临床评估(心脏杂音听诊)筛查新生儿危重型先天性心脏病的系统评价和Meta分析[J]. 中国循证儿科杂志,2020,15(5):325-332.
[3]	宋宏琳, 卢江, 周汝芳, 等. 中国五省中小学生社区筛查先心病患病率与海拔及民族关系[J]中国公共卫生, 2021, 37（10）: 1514-1516.
[4]	顾虹. 《中国肺动脉高压诊断与治疗指南(2021版)》解读——聚焦先天性心脏病相关肺动脉高压[J]. 中国实用内科杂志,2021,41(10):855-858.
[5]	刘雪贞,纪龙,张倩倩,等. 基于中国知网数据库(2007-2017)新生儿先心病研究的可视化分析[J]. 现代预防医学,2018,45(15):2756-2760.
[6]	李春妮,王峥. 产前超声诊断对先天性心脏病的诊断价值和漏诊及误诊的原因分析[J]. 昆明医科大学学报,2020,41(10):138-143.
[7]	刘媛媛. 实时三维超声用于先天性心脏病诊治中的进展[J]. 中国医疗器械信息,2021,27(12):17-18,190.
[8]	唐欣,叶洪强. 心脏杂音听诊综合考虑与诊断分析[J]. 临床合理用药,2019,12(12):51-52.
[9]	陆小涛,官子夺,达志煜,等. 先天性心脏病听诊及脉搏氧饱和度筛查诊断的排除标准[J]. 中国临床医学影像杂志,2020,31(7):1072-1074.
[10]	徐理想,刘雨欣,覃杰,等. 结合心脏杂音与脉搏氧饱和度检测的新生儿先天性心脏病筛查[J]. 中国实用医药,2020,15(19):5-7.
[11]	王晓红,史少娟,刘学,等. 先天性心脏病合并肺动脉高压患儿行根治术后的预后影响因素分析[J]. 东南国防医药,2021,23(2):131-135.
[12]	王灵玲,张赟. 2014-2019年台州市立医院新生儿先天性心脏病筛查情况[J]. 中国妇幼保健,2021,36(24):5800-5802.
[13]	泮思林,罗刚. 推进中国胎儿结构性心脏病宫内干预的相关问题与对策[J]. 中国实用儿科杂志,2021,36(5):332-335.
[14]	陈宇雨,路发文,杨帆,等. 新生儿危重先天性心脏病的术前术后一体化救治经验[J]. 中国心血管病研究,2021,19(7):623-628.
[15]	曹景颖,吴信,陈寄梅,等. 坚守初心与使命-我国先天性心脏病事业的开创与继承[J]. 中国心血管病研究,2021,19(7):577-581.
[16]	马新平,刘彩霞,秦珍珍. 新生儿危重先天性心脏病的围术期治疗策略[J]. 中国药物与临床,2021,21(17):2978-2980.
[17]	赵书嫣. 先天性心血管疾病筛查与基层医生培训进展[J]. 重庆医学,2018,47(17):2329-2332. doi: 10.3969/j.issn.1671-8348.2018.17.020
[18]	杨杪,贾品,田友平,等. 新生儿先天性心脏病筛查及成果转化探讨[J]. 医院管理论坛,2022,39(10):18-20. doi: 10.3969/j.issn.1671-9069.2022.10.005
[19]	陈纲,关吏,陈伟呈,等. 先天性心脏病产前产后诊治一体化管理初步经验[J]. 临床小儿外科杂志,2021,20(6):525-531.
[20]	陈叶,龚敬宇,杜鹃. 新生儿先天性心脏病筛查的临床价值分析[J]. 中国妇幼健康研究,2019,30(9):1125-1128.
[21]	董媛,张坚,李瑞真,等. 心脏杂音联合经皮血氧饱和度在新生儿先天性心脏病筛查中的应用价值[J]. 河北医药,2021,43(16):2459-2462.
[22]	刘丹. 心脏彩超在新生儿先天性心脏病筛查中的应用[J]. 中国冶金工业医学杂志,2022,39(2):243. doi: 10.13586/j.cnki.yjyx1984.2022.02.112

Relative Articles(20)

Relative Articles

[1]	Ting HU, Luyao WANG, Jing LIANG, Jing ZHANG, Jiao LENG, Xiufang LI. A Survey on the Current Situation of Demand for Extended Nursing Services for Newborns after Discharge. Journal of Kunming Medical University, 2024, 46(): 1-7.
[2]	Tuan LI, Yu’e ZHOU, Li MA, Gui LIAO. Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice. Journal of Kunming Medical University, 2023, 44(1): 80-84. doi: 10.12259/j.issn.2095-610X.S20230122
[3]	Weijie LI, Liqin CHEN, Yaling LI, Yonghui HAN, Xiaojuan LI, Ruogu WANG. Epidemiology of CRKP Infection Outbreak in a Neonatal Intensive Care Unit. Journal of Kunming Medical University, 2023, 44(12): 144-149. doi: 10.12259/j.issn.2095-610X.S20231223
[4]	Shuangshuang WANG, Liqin CHEN, Yaling LI, Weijie LI, Jiayi YANG. Analysis of Epidemiological Characteristics of Neonatal Rotavirus Infection from 2020 to 2022. Journal of Kunming Medical University, 2023, 44(5): 26-31. doi: 10.12259/j.issn.2095-610X.S20230509
[5]	Caiying ZHANG, Zhengping KUI, Qiong WANG, Xiaolong ZHAO, Xiaomei HOU, Zhiye QI. Perinatal Risk Factors of Neonatal Hyperthyrotropinemia. Journal of Kunming Medical University, 2022, 43(9): 48-52. doi: 10.12259/j.issn.2095-610X.S20220929
[6]	Jie WU, Jun LIU, Yan ZHANG, Xudong DONG, Xingzi FENG, Qinnan LU, Lingyan LIU. Analysis on the Trend of Birth Weight of 36551 Newborns in Last Ten Years. Journal of Kunming Medical University, 2022, 43(4): 75-81. doi: 10.12259/j.issn.2095-610X.S20220414
[7]	Jing WANG, Lian-fang TANG, Mei-qun GU, Xiao-yan XU, Jian-hua YU, Shan HE, Zi-wei LI, Kai BI, Li-qiao LIU, Qiong ZHAO, Hong-ying MI. Risk Factors and Early Clinical Characteristics of Neonatal Necrotizing Enterocolitis. Journal of Kunming Medical University, 2021, 42(11): 99-104. doi: 10.12259/j.issn.2095-610X.S20211118
[8]	Xiao Yan , Mi Hong Ying , Hu Jian Ying , Liu Yu . . Journal of Kunming Medical University, 2020, 41(01): 73-79.
[9]	Yang Hui Bo , Yu Run Liu , Miao Qin , Liu De Liang . . Journal of Kunming Medical University, 2020, 41(07): 144-148.
[10]	He Ling , Xiao Jing , Yang Bi Yan , Wang Song . . Journal of Kunming Medical University, 2019, 40(07): 84-87.
[11]	Jiang Yu Hui , Liu Ling , He Can Lin , Li Yang . . Journal of Kunming Medical University, 2019, 40(04): 20-22.
[12]	Li Zhen , Ye Qing , He Biao Hua , Li Guan Xi , Wang Hong , Zeng Yong Li , Yu Zhuo , Li Hua , Chen Zhi Song . Epidemiological Investigation on Children and Teenagers with Congenital Heart Disease in three Counties in Zhaotong Area from 2015 to 2016. Journal of Kunming Medical University, 2018, 39(03): 77-80.
[13]	Xia Li Bin , Shi Xin , Shen Yan , Luo Zhi Ling . . Journal of Kunming Medical University, 2018, 39(12): 16-22.
[14]	Yang Xu , Ma Run Wei , Song Yi , Zhang Xiao Yu , Wang Ji Yang , Zhang Da Yong . . Journal of Kunming Medical University, 2017, 38(05): 68-73.
[15]	Han Ci Lin , Jiang Li Hong , Hou Zong Liu , Wang Wen Ju , Zhang Yu . Epidemic Characteristics of Congenital Heart Disease of Adolescents between 3 to 18 ages Among Different Regions in Yunnan. Journal of Kunming Medical University, 2017, 38(08): 30-34.
[16]	Zhang Yi . . Journal of Kunming Medical University,
[17]	Ding Yun Chuan . . Journal of Kunming Medical University,
[18]	Chen Wen Min . . Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	Wen Yong . . Journal of Kunming Medical University,