Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect  on Peripheral Blood PD-1 and PD-L1

Xia ZHANG; Wensha NIE; Huiping WANG; Zuohua WANG; Chunxia WANG; Yuxia ZHENG

doi:10.12259/j.issn.2095-610X.S20230428

Volume 44 Issue 4

Apr. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(4): 123-127

Xia ZHANG, Wensha NIE, Huiping WANG, Zuohua WANG, Chunxia WANG, Yuxia ZHENG. Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect on Peripheral Blood PD-1 and PD-L1[J]. Journal of Kunming Medical University, 2023, 44(4): 123-127. doi: 10.12259/j.issn.2095-610X.S20230428

Citation:

Xia ZHANG, Wensha NIE, Huiping WANG, Zuohua WANG, Chunxia WANG, Yuxia ZHENG. Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect on Peripheral Blood PD-1 and PD-L1[J]. Journal of Kunming Medical University, 2023, 44(4): 123-127. doi: 10.12259/j.issn.2095-610X.S20230428

Citation:

Xia ZHANG, Wensha NIE, Huiping WANG, Zuohua WANG, Chunxia WANG, Yuxia ZHENG. Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect on Peripheral Blood PD-1 and PD-L1[J]. Journal of Kunming Medical University, 2023, 44(4): 123-127. doi: 10.12259/j.issn.2095-610X.S20230428

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Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect on Peripheral Blood PD-1 and PD-L1

doi: 10.12259/j.issn.2095-610X.S20230428

Dept. of Neurology，Kunming Children’s Hospital，Kunming Yunnan 650103，China

Received Date: 2023-01-11
Available Online: 2023-04-24
Publish Date: 2023-04-25

Abstract

Abstract

Objective To investigate the efficacy of rituximab combined with methylprednisolone in the treatment of autoimmune encephalitis （AE） and its effect on programmed death factor-1 （PD-1） and programmed death factor ligand 1 （PD-L1） in peripheral blood. Methods A total of 60 patients with AE admitted to Kunming Children's hospital from February 2019 to July 2022 were selected as research subjects, and were divided into observation group （n = 30） and control group （n = 30） according to random number table. The control group was treated with methylprednisolone, and the observation group was treated with rituximab combined with methylprednisolone. Both groups were evaluated after 4 weeks of treatment. The curative effect, T lymphocyte subsets, peripheral blood PD-1, PD-L1 levels and immunoglobulin levels were compared between the two groups. Results The total effective rate of the observation group （90.00%） was higher than that of the control group （66.67%）, P < 0.05. After treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the observation group were higher than those in the control group, and the level of CD8⁺ was lower than that in the control group （P < 0.05）. PD-1 and PD-L1 in peripheral blood were higher than those in control group （P < 0.05）, and the levels of IgA, IgG and IgM in the control group were obviously lower than those in the control group （P < 0.05）. Conclusion Rituximab combined with methylprednisolone has a definite therapeutic effect on AE; it can improve the immune function of the body and increase PD-1 and PD-L1 levels. Our findings can be used as a guide for clinical application.
- Rituximab,
- Methylprednisolone,
- Autoimmune encephalitis,
- Programmed death factor-1,
- Programmed death factor ligand-1

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