Use and Replacement of Treatment Regimens for AIDS Patients on Antiretroviral Therapy

Bo TIAN; Chongxi LI; Yongmei JIN; Wei GUAN; Haiyun CHEN; Jun LIU

doi:10.12259/j.issn.2095-610X.S20230508

Volume 44 Issue 5

May 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(5): 162-167

Bo TIAN, Chongxi LI, Yongmei JIN, Wei GUAN, Haiyun CHEN, Jun LIU. Use and Replacement of Treatment Regimens for AIDS Patients on Antiretroviral Therapy[J]. Journal of Kunming Medical University, 2023, 44(5): 162-167. doi: 10.12259/j.issn.2095-610X.S20230508

Citation:

Bo TIAN, Chongxi LI, Yongmei JIN, Wei GUAN, Haiyun CHEN, Jun LIU. Use and Replacement of Treatment Regimens for AIDS Patients on Antiretroviral Therapy[J]. Journal of Kunming Medical University, 2023, 44(5): 162-167. doi: 10.12259/j.issn.2095-610X.S20230508

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Use and Replacement of Treatment Regimens for AIDS Patients on Antiretroviral Therapy

doi: 10.12259/j.issn.2095-610X.S20230508

The Third People’s Hospital of Kunming/ Yunnan Clinical Medical Center for Infectious Diseases. Kunming Yunnan 650041，China

Received Date: 2022-10-25
Available Online: 2023-05-11
Publish Date: 2023-05-25

Abstract

Abstract

Objective To understand the use of primary and menstrual ART regimens for HIV patients receiving antiviral treatment in different periods, and to analyze the dressing change situation and reasons of different drug combinations. Methods Patients initially enrolled in ART from January 2017 to June 2022 were included in the study. The demographic characteristics and the changes of the primary and menstrual ART regimens of the participants in different periods were analyzed and the differences in dressing change rates between the different regimens were compared. Results Most of the subjects were male, The average age was 41.35±14.2 years old and there was an increasing trend （P < 0.001）. TDF/AZT+3TC+EFV was the main ART regimens in newly diagnosed patients, but the utilization rate decreased after the treatment. The TDF+3TC+EFV regimen had the highest dressing change rate （17.3%）. Compared with the initial treatment, the utilization rate of the protocol containing LPV/r increased. Integrase-containing regimens increased significantly in the treated patients in 2021 and early 2022 （P < 0.001）. Drug change rates did not differ at 1, 2, 3, 4, and 5 years of treatment （P = 0.376）. The main reason for dressing change was drug side effects （57.4%）. Conclusion The selection of ART drugs gradually switches from nucleoside and non-nucleosides to integrase inhibitors.The choice of ART drugs is gradually changing from the nucleoside non-nucleoside to integrase inhibitor, which tends to be individualized. Combining the clinical characteristics and complications of patients and choosing the most efficient, low-toxic and simple scheme are more conducive to the long-term effective treatment of patients.
- HIV,
- AIDS,
- ART,
- Programme,
- Change of dressing

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