Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis

Chenglin YANG; Jie HU; Jing WANG; Minhua WANG; Ling HUANG

doi:10.12259/j.issn.2095-610X.S20230511

Volume 44 Issue 5

May 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(5): 95-101

Chenglin YANG, Jie HU, Jing WANG, Minhua WANG, Ling HUANG. Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis[J]. Journal of Kunming Medical University, 2023, 44(5): 95-101. doi: 10.12259/j.issn.2095-610X.S20230511

Citation:

Chenglin YANG, Jie HU, Jing WANG, Minhua WANG, Ling HUANG. Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis[J]. Journal of Kunming Medical University, 2023, 44(5): 95-101. doi: 10.12259/j.issn.2095-610X.S20230511

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Clinical Correletions between Helper T Cells 17，Regulatory T Cells and Chronic Actinic Dermatitis

doi: 10.12259/j.issn.2095-610X.S20230511

1.
Dept.of Internal Medicine，Dali Nursing Vocational College，Dali Yunnan，671000
2.
Dept.of Dermatology，Traditional Chinese Hospital of LuAn，Luan Anhui 237000
3.
Dept.of Dermatology，Jinshan Hospital of Fudan University，Shanghai 200540
4.
Dept.of Dermatology，The 1st Affiliated Hospital of Dali University，Dali Yunnan 671001，China

Received Date: 2023-01-16
Available Online: 2023-05-11
Publish Date: 2023-05-25

Abstract

Abstract

Objective To investigate the the possible roles of helper T cells 17 （Thl7 cells） and regulatory T cells （Treg cells） of chronic actinic dermatitis. Methods The percentages of Th17 cells and Treg cells in CD4+ T cells in peripheral blood of 25 CAD patients and 20 healthy volunteers were detected by flow cytometry, and the expression of IL-17 and Foxp3 in skin lesions of 25 patients with chronic actinic dermatitis and 10 healthy people were detected by immunohistochemistry. Results Compared with the healthy volunteers, Th17 cells in CAD patients were significantly more than those in volunteers; Treg cells in CAD patients were significantly less than those in volunteers; Th17/Treg in CAD patients was significantly higher than that in volunteers and all the differences were statistically significant （P < 0.05）. The correlation coefficients of Th17 cells and EASI scores showed that there was a positive correlation between them （P < 0.05）; the correlation coefficients of Treg cells and EASI scores showed that there was a negative correlation between them. The expression of IL-17 in lesions of CAD group was higher than that of healthy control group and the difference was statistically significant （P < 0.05）. There was no significant difference in the expression of Foxp3 in the skin compared with the healthy control group （P > 0.05）. Conclusion The imbalance of Th17/Treg in patients with CAD leads to the development of immune response to pro-inflammatory, which may be an important pathogenesis of CAD.
- Chronic actinic dermatitis,
- T help cells 17,
- Regulatory T cells

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References(16)

References

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