Clinical Application of Esketamine Combined with Propofol in Painless Abortion

Ningli ZHANG; Chen ZHOU; Yongyu SI; Jie OUYANG; Lan LIN; Ying CHEN; Qin NIU; Hong LI

doi:10.12259/j.issn.2095-610X.S20230514

Volume 44 Issue 5

May 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(5): 102-106

Ningli ZHANG, Chen ZHOU, Yongyu SI, Jie OUYANG, Lan LIN, Ying CHEN, Qin NIU, Hong LI. Clinical Application of Esketamine Combined with Propofol in Painless Abortion[J]. Journal of Kunming Medical University, 2023, 44(5): 102-106. doi: 10.12259/j.issn.2095-610X.S20230514

Citation:

Ningli ZHANG, Chen ZHOU, Yongyu SI, Jie OUYANG, Lan LIN, Ying CHEN, Qin NIU, Hong LI. Clinical Application of Esketamine Combined with Propofol in Painless Abortion[J]. Journal of Kunming Medical University, 2023, 44(5): 102-106. doi: 10.12259/j.issn.2095-610X.S20230514

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Clinical Application of Esketamine Combined with Propofol in Painless Abortion

doi: 10.12259/j.issn.2095-610X.S20230514

Dept. of Anesthesia，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2023-01-18
Available Online: 2023-05-12
Publish Date: 2023-05-25

Abstract

Abstract

Objective To explore the advantages of esketamine combined with propofol in painless abortion. Methods 50 patients who underwent the painless abortion were selected and randomly divided into the control group and the observation group, with 25 in each group. The control group received Fentanyl combined with propofol intravenous anesthesia while the observation group received Esketamine combined with propofol intravenous anesthesia and the HR, MAP and SpO₂ before the induction （T1）, immediately after the operation （T2）, 3 min after the operation （T3） and immediately after the operation （T4） was recorded respectively. The time of consciousness loss and recovery, operation duration and dosage of propofol were recorded. The intraoperative body motor reaction, propofol injection pain, circulation depression, respiratory depression, postoperative adverse reactions and postoperative pain were scored （VAS score）. Results The comparison of the operation time, propofol dose, VAS score and recovery time between the two groups proved to be statistically insignificant （P > 0.05）. At T3, MAP, HR, and SpO₂ in the control group were lower than those in the observation group （P < 0.05）; The incidence of injection pain, postoperative dizziness, nausea, and vomiting between the two groups proved to be statistically insignificant （P > 0.05）. The incidence of body movement, respiration, and circulation depression in the observation group was lower than that in the control group （P < 0.05）; The overall incidence of adverse reactions in the observation group was lower than that in the control group （P < 0.05）. Conclusion The application of esketamine combined with propofol in TIVA for painless abortion has been proved to be safe and feasible, and can reduce the incidence of intraoperative body motor reaction, respiratory circulation inhibition and other adverse reactions, and maintain the stability of intraoperative hemodynamics.
- Esketamine,
- Propofol,
- Painless abortion,
- Intravenous anesthesia

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References(18)

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