Clinical Observation of SGLT-2 Inhibitors in Delaying the Progression of Diabetic Nephropathy

Ling ZHAO; Hongling ZHONG; Xinru GAO; Mei LI; Tingting MAO; Rongyong LI; Tingyu KE

doi:10.12259/j.issn.2095-610X.S20230527

Volume 44 Issue 5

May 2023

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Ling ZHAO, Hongling ZHONG, Xinru GAO, Mei LI, Tingting MAO, Rongyong LI, Tingyu KE. Clinical Observation of SGLT-2 Inhibitors in Delaying the Progression of Diabetic Nephropathy[J]. Journal of Kunming Medical University, 2023, 44(5): 60-65. doi: 10.12259/j.issn.2095-610X.S20230527

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Clinical Observation of SGLT-2 Inhibitors in Delaying the Progression of Diabetic Nephropathy

doi: 10.12259/j.issn.2095-610X.S20230527

1.
Dept. of Endocrinology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
2.
The 2nd Clinical Medical College of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2023-02-17
Available Online: 2023-05-10
Publish Date: 2023-05-25

Abstract

Abstract

Objective To investigate the clinical efficacy of SGLT2 inhibitors in delaying the progression of diabetic nephropathy based on "real world" clinical data. Methods A retrospective analysis was performed on 98 patients with diabetes who were treated with SGLT2 inhibitors from the MMC database of the Second Affiliated Hospital of Kunming Medical University from January 2019 to December 2022. The baseline data of treatment with SGLT2 inhibitors were taken as the baseline and the data of 6 months of treatment were collected. （1） General data [age, sex, height, BMI, systolic blood pressure, diastolic blood pressure] were compared between baseline and 6 months of the treatment; （2） Indexes of glucose metabolism [blood glucose, glycosylated hemoglobin （HbA1c）]; （3） Liver function indexes [AST, ALT, alkaline phosphatase, YGT, ALB]; （4） Lipid indexes [total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDLc）, low density lipoprotein （LDLc）]; （5） Renal function indicators [urinary creatinine, urinary microalbumin, urinary microalbumin/creatinine （UACR）, urea nitrogen （BUN）, uric acid （UA）, creatinine （Cr）]. Following the "6 month interval" method, 98 patients with relatively complete data admitted to the hospital from January 2019 to December 2022 were divided into baseline group （98 cases, initial use of SGLT2 inhibitor） and 6 month group （98 cases, SGLT2 inhibitor treatment for 6 months）. Results The baseline age of the patients included in this study was 52.85±8.98 years old, and the baseline height was 167.62±8.04cm, including 72 males, accounting for 73.47%, and 26 females, accounting for 26.53%.After the 6 months of treatment: （1） The BMI, systolic blood pressure and diastolic blood pressure of the patients were lower than the baseline. There were significant differences in diastolic blood pressure （P < 0.05）. （2） The indexes of glucose metabolism, blood glucose and HbA1c were lower than the baseline, and the differences between the two indexes were statistically significant （P < 0.05）. （3） The liver function indexes AST, ALT, ALP, YGT and ALB were lower than the baseline, and the difference in ALT was statistically significant （P < 0.05）. （4） Lipid indexes TC, TG and LDLc were lower than the baseline, while HDLc was higher than the baseline, and the difference between TG and HDLc indexes was statistically significant （P < 0.05）. （5） The renal function indexes as urinary microalbumin, urinary microalbumin/creatinine （UACR） and urea nitrogen （BUN） were lower than the baseline, urinary creatinine, uric acid （UA） and creatinine （Cr） were higher than the baseline, and the differences in urinary microalbumin/creatinine （UACR） indexes were statistically significant （P<0.05）. Adverse reactions: In this study, no hypoglycemia, severe gastrointestinal reaction, urinary tract infection, lower limb wound injury or amputation were observed between the two groups. Conclusion SGLT2 inhibitors have the effects of lowering blood pressure, reducing body massindex controlling blood sugar level, regulating lipid metabolism, improving the renal function and reducing urinary protein in diabetic nephropathy patients. It can delay the progression of diabetic nephropathy and has high clinical safety.
- Diabetic nephropathy,
- SGLT2 inhibitors,
- Clinical efficacy,
- Safety

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References

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