Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma

Ting LI; Wei-Hua GUO

doi:10.12259/j.issn.2095-610X.S20230611

Volume 44 Issue 6

Jun. 2023

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Ting LI, Wei-Hua GUO. Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(6): 155-161. doi: 10.12259/j.issn.2095-610X.S20230611

Citation:

Ting LI, Wei-Hua GUO. Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2023, 44(6): 155-161. doi: 10.12259/j.issn.2095-610X.S20230611

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Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma

doi: 10.12259/j.issn.2095-610X.S20230611

Ting LI^{1, 2, 3, 4, 5},
Wei-Hua GUO^{1, 2, 3, 4, 5, 6
,
,}

1.
National Laboratory for Oral Regenerative Medicine Engineering，West China Hospital of Stomatology，Sichuan University
2.
Engineering Research Center of Oral Translational Medicine，West China Hospital of Stomatology，Sichuan University
3.
National Key Laboratory of Oral Diseases，West China Hospital of Stomatology
4.
National Clinical Research Center for Oral Diseases，West China Hospital of Stomatology，Sichuan University，Chengdu
5.
Department of Pediatric Dentistry，West China School of Stomatology，Chengdu Sichuan 610041
6.
Yunnan Key Laboratory of Stomatology，The Affiliated Hospital of Stomatology，School of Stomatology，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-03-09
Publish Date: 2023-06-25

Abstract

Abstract

Oral squamous cell carcinoma （OSCC） is the most common malignant tumor in the oral and maxillofacial region with high incidence and poor prognosis. Cancer cells change their metabolism through glycolytic metabolic reprogramming to support their increased demand for ATP. Glycolytic reprogramming mediates the development of multisystem tumors, including oral squamous cell carcinoma, involving multiple signaling pathways and key factors. In this paper, the changes of glycolytic metabolism, key factors and potential clinical diagnostic and theraputic approches of OSCC are summarized, and the role of OSCC in oral squamous cell carcinoma is reviewed in order to provide new research directions and ideas.
- Glycolysis metabolism,
- Oral squamous cell carcinoma,
- Cell proliferation,
- Molecular targeted therapy

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References(53)

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