Application of IBS and FSI Methods in the Full Sibling Testing of Yunnan Population

Na YI; Renwu HUANG; Jiamei JIANG; Cunwei MENG; Hao YE; Xiangping LI; Linlin LIU; Liping HU

doi:10.12259/j.issn.2095-610X.S20230626

Volume 44 Issue 6

Jun. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(6): 131-135

Na YI, Renwu HUANG, Jiamei JIANG, Cunwei MENG, Hao YE, Xiangping LI, Linlin LIU, Liping HU. Application of IBS and FSI Methods in the Full Sibling Testing of Yunnan Population[J]. Journal of Kunming Medical University, 2023, 44(6): 131-135. doi: 10.12259/j.issn.2095-610X.S20230626

Citation:

Na YI, Renwu HUANG, Jiamei JIANG, Cunwei MENG, Hao YE, Xiangping LI, Linlin LIU, Liping HU. Application of IBS and FSI Methods in the Full Sibling Testing of Yunnan Population[J]. Journal of Kunming Medical University, 2023, 44(6): 131-135. doi: 10.12259/j.issn.2095-610X.S20230626

Citation:

Na YI, Renwu HUANG, Jiamei JIANG, Cunwei MENG, Hao YE, Xiangping LI, Linlin LIU, Liping HU. Application of IBS and FSI Methods in the Full Sibling Testing of Yunnan Population[J]. Journal of Kunming Medical University, 2023, 44(6): 131-135. doi: 10.12259/j.issn.2095-610X.S20230626

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Application of IBS and FSI Methods in the Full Sibling Testing of Yunnan Population

doi: 10.12259/j.issn.2095-610X.S20230626

Na YI¹,
Renwu HUANG^{1, 2},
Jiamei JIANG¹,
Cunwei MENG¹,
Hao YE¹,
Xiangping LI¹,
Linlin LIU^{1, 2},
Liping HU^{1, 2
,
,}

1.
School of Forensic Medicine，Kunming Medical University
2.
Judicial Identification Center of Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-02-25
Available Online: 2023-06-16
Publish Date: 2023-06-25

Abstract

Abstract

Objective To explore the applicability of IBS and FSI methods in the identification of full sibling relationship in Yunnan population. Methods A total of 448 pairs of full siblings and 1020 pairs of unrelated individuals were genotyped for 19 STR loci, and CIBS and CFSI were calculated. Descriptive statistics, normality test and t-test were performed for lgCFSI values and CIBS values of whole sibling pairs and unrelated individual pairs using SPSS 25.0 software. χ² test was used for counting data. Results The lgCFSI and CIBS values of the whole sibling group and the unrelated individual group were in normal distribution. The difference between the unrelated individual group and the full sibling group was statistically significant in both the IBS and FSI methods. The statistical comparison of the difference between the three cutt-offs dividing methods in the old and new standards is statistically significant. For 19 autosomal STR loci, the system power of the three methods in the two standards were 0.7500, 0.5565 and 0.6625, respectively, while the system power of the Yunnan population in this study were 0.7405, 0.5109 and 0.6621, respectively. Conclusion The new standard has a high value of forensic medicine application in the identification of full sibling relationship in Yunnan. The IBS method and FSI method based on 19 autosomal STR loci detection system can effectively reduce the risk of misjudgment in the identification of full sibling relationship.
- Full sibling,
- IBS,
- FSI

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References(14)

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