Analysis of Clinical Diagnosis and Treatment of Nonfunctional Pancreatic Neuroendocrine Neoplasms

Jing LI; Lin WANG; Qiang KANG; Yuehua LI; Hong ZHU; Yixuan CHEN; Xuefen LEI

doi:10.12259/j.issn.2095-610X.S20230706

Volume 44 Issue 7

Jul. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 47-51

Jing LI, Lin WANG, Qiang KANG, Yuehua LI, Hong ZHU, Yixuan CHEN, Xuefen LEI. Analysis of Clinical Diagnosis and Treatment of Nonfunctional Pancreatic Neuroendocrine Neoplasms[J]. Journal of Kunming Medical University, 2023, 44(7): 47-51. doi: 10.12259/j.issn.2095-610X.S20230706

Citation:

Jing LI, Lin WANG, Qiang KANG, Yuehua LI, Hong ZHU, Yixuan CHEN, Xuefen LEI. Analysis of Clinical Diagnosis and Treatment of Nonfunctional Pancreatic Neuroendocrine Neoplasms[J]. Journal of Kunming Medical University, 2023, 44(7): 47-51. doi: 10.12259/j.issn.2095-610X.S20230706

Citation:

Jing LI, Lin WANG, Qiang KANG, Yuehua LI, Hong ZHU, Yixuan CHEN, Xuefen LEI. Analysis of Clinical Diagnosis and Treatment of Nonfunctional Pancreatic Neuroendocrine Neoplasms[J]. Journal of Kunming Medical University, 2023, 44(7): 47-51. doi: 10.12259/j.issn.2095-610X.S20230706

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Analysis of Clinical Diagnosis and Treatment of Nonfunctional Pancreatic Neuroendocrine Neoplasms

doi: 10.12259/j.issn.2095-610X.S20230706

1.
Dept. of Hepatopancreatobiliary Surgery
2.
Dept. of Oncology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2023-05-23
Available Online: 2023-07-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To investigate the prognosis of surgical resection in patients with nonfunctioning pancreatic neuroendocrine neoplasms （NF-pNENs）. Methods The clinical and follow-up data of 45 patients who were pathologically confirmed NF-pNENs in the Second Affiliated Hospital of Kunming Medical University from January 2011 to December 2020 were retrospectively analyzed. Results The follow-up time was 6 to 112 months, and the median follow-up time was 47 months. A total of 43 patients were followed up. Postoperative recurrence occurred in 1 case, distant metastasis in 2 cases, 40 cases survived, and 3 cases died, one well-differentiated G2 patient died 83 months after surgery due to multiple systemic metastasis, and two poorly differentiated G3 patients died 6 months after surgery. The 5-year postoperative survival rate of patients with NF-pNENs was 95.3%. Univariate analysis showed that the tumor WHO grade and lymph node metastasis were related to the prognosis of NF-pNENs patients, and the difference was statistically significant （P < 0.05）. Multivariate analysis did not suggest independent factors affecting the prognosis of NF-pNENs. Conclusions Surgery is the only cure for pNENs currently, which is available in specialized pancreatic centers. Preoperative identification of WHO grade and lymph node metastasis is conducive to the choice of surgical mode. Standard intraoperative lymph node dissection is required to obtain a sufficient number of lymph nodes to clarify the metastasis, so as to better guide the prognostic evaluation.
- Pancreatic neuroendocrine neoplasms,
- Surgery,
- Curative effect

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