Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children

Lu LI; Yunfen TIAN

doi:10.12259/j.issn.2095-610X.S20230708

Volume 44 Issue 7

Jul. 2023

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Lu LI, Yunfen TIAN. Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children[J]. Journal of Kunming Medical University, 2023, 44(7): 148-155. doi: 10.12259/j.issn.2095-610X.S20230708

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Lu LI, Yunfen TIAN. Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children[J]. Journal of Kunming Medical University, 2023, 44(7): 148-155. doi: 10.12259/j.issn.2095-610X.S20230708

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Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children

doi: 10.12259/j.issn.2095-610X.S20230708

Lu LI,
Yunfen TIAN^,

Dept. of Pediatrics，The Affiliated Hospital of Kunming University of Science and Technology/ Dept. of Pediatrics，The 1st People’s Hospital of Yunnan Province， Kunming Yunnan 650032，China

Received Date: 2022-02-24
Available Online: 2023-07-18
Publish Date: 2023-07-25

Abstract

Abstract

Pediatric non-alcoholic fatty liver disease （NAFLD） is the most common cause of pediatric chronic liver disease worldwide, and its incidence is gradually increasing with the global epidemic of obesity, but there is no standardized and effective treatment plan. At present, the pathogenesis of NAFLD has not been fully elucidated, Among many pathogenic factors, intestinal microflora disorder is the current research hotspot, which opens up a new direction for the diagnosis, prevention, and treatment of NAFLD. However, the treatment of NAFLD in children is still being explored. In this paper, the possible mechanism of intestinal flora and its metabolites mediating NAFLD in children in recent years was reviewed, as well as the diagnosis and treatment methods using intestinal flora as an intervention target, hoping to provide some new ideas and methods for the treatment of NAFLD in children.
- Non-alcoholic fatty liver disease,
- Children,
- Gut microbiota,
- Gut-liver axis,
- Targeted therapy

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References(72)

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