Correlation of <i>ERAP</i> Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine

Yuhan SHI; Jing LI; Shuyuan LIU; Ting ZHAO; Jingsi YANG; Li SHI; Jiangli LIANG

doi:10.12259/j.issn.2095-610X.S20230711

Volume 44 Issue 7

Jul. 2023

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Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG. Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine[J]. Journal of Kunming Medical University, 2023, 44(7): 22-28. doi: 10.12259/j.issn.2095-610X.S20230711

Citation:

Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG. Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine[J]. Journal of Kunming Medical University, 2023, 44(7): 22-28. doi: 10.12259/j.issn.2095-610X.S20230711

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Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine

doi: 10.12259/j.issn.2095-610X.S20230711

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
College of Agronomy and Biotechnology，Yunnan Agricultural University，Kunming Yunnan 650201，China

Received Date: 2023-06-11
Available Online: 2023-07-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To analyze the relationship between endoplasmic reticulum aminopeptidases （ERAP） gene polymorphisms and serum polio antibodies induced by sequential polio vaccine immunization. Methods A total of 243 Zhuang individuals were selected from the Guangxi Zhuang Autonomous Region who received two doses of inactivated polio vaccine and one dose of bivalent oral polio vaccine. Polio-neutralizing antibodies types I, II and III were tested from pre-immunization and 28 days after immunizations, and six ERAP1 and two ERAP2 SNPs were genotyped using TaqMan probe genotyping. The allele frequency and genotype frequency were calculated for each SNP, and the association between the SNPs and the polio antibody response was analyzed. Results It was found that individuals carrying the rs2549782-G andrs2248374-A allele of the ERAP1 gene had lower levels of type I polio-neutralizing antibodies compared to those carrying the T and G alleles, respectively （both of 11.590±1.979 vs 11.950±1.895, Padj = 0.031）. In addition, it was observed that GT and AG genotypes of rs2549782 of rs2248374 exhibited lower GMT type I polio-neutralizing antibodies than those of TT and GG genotypes （both of 11.741±0.141 vs 12.378±0.157, Padj = 0.045）. Conclusion Polio vaccine-induced antibody responses may be associated with ERAP2 gene polymorphism.

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References(31)

References

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