The Relationship between Arsenic Exposure and DNA Damage of EGFR，PTEN，Kras，and PIK3CA Genes in Arsenic Factory Workers

Jiang WU; He MA; Jinyun JIANG; Na LIU; Ruihuan ZHAO; Yuefeng HE

doi:10.12259/j.issn.2095-610X.S20230717

Volume 44 Issue 7

Jul. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 29-33

Jiang WU, He MA, Jinyun JIANG, Na LIU, Ruihuan ZHAO, Yuefeng HE. The Relationship between Arsenic Exposure and DNA Damage of EGFR，PTEN，Kras，and PIK3CA Genes in Arsenic Factory Workers[J]. Journal of Kunming Medical University, 2023, 44(7): 29-33. doi: 10.12259/j.issn.2095-610X.S20230717

Citation:

Jiang WU, He MA, Jinyun JIANG, Na LIU, Ruihuan ZHAO, Yuefeng HE. The Relationship between Arsenic Exposure and DNA Damage of EGFR，PTEN，Kras，and PIK3CA Genes in Arsenic Factory Workers[J]. Journal of Kunming Medical University, 2023, 44(7): 29-33. doi: 10.12259/j.issn.2095-610X.S20230717

Citation:

Jiang WU, He MA, Jinyun JIANG, Na LIU, Ruihuan ZHAO, Yuefeng HE. The Relationship between Arsenic Exposure and DNA Damage of EGFR，PTEN，Kras，and PIK3CA Genes in Arsenic Factory Workers[J]. Journal of Kunming Medical University, 2023, 44(7): 29-33. doi: 10.12259/j.issn.2095-610X.S20230717

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The Relationship between Arsenic Exposure and DNA Damage of EGFR，PTEN，Kras，and PIK3CA Genes in Arsenic Factory Workers

doi: 10.12259/j.issn.2095-610X.S20230717

1.
Dept. of Physical Education，Kunming Medical University
2.
Key Laboratory of Public Health and Disease Control，Education Department of Yunnan Province，School of Public Health，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-06-01
Available Online: 2023-07-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To explore the relationship between DNA damage and urinary arsenic metabolism in four genes of EGFR, PTEN, Kras and PIK3CA in workers exposed to arsenic in arsenic factories. Methods A total of 78 first-line occupational arsenic exposure workers in an arsenic factory in Yunnan were selected as the exposure group and 24 people without history of arsenic exposure were included as the control group. The DNA damage of EGFR, PTEN, Kras and PIK3CA genes in peripheral blood lymphocytes was detected by real-time fluorescence quantitative PCR, and the contents of inorganic arsenic, monomethyl arsine acid and dimethylamine in the urine of all workers were detected and the percentages were calculated. Results The DNA damage and mean damage of the four genes in the occupational arsenic exposure group were significantly higher than those in the control group （P < 0.05）. The mean damage of the four genes was positively correlated with inorganic arsenic, monomethyl arsine acid, dimethylamine acid, and the percentage of monomethyl arsine in urine and negatively correlated with the percentage of dimethylamine （P < 0.05）. Conclusion The damage of important genes caused by arsenic exposure and the average damage of four genes have the potential to be used as markers of damage assessment.
- Arsenic,
- EGFR,
- PTEN,
- Kras,
- PIK3CA

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References(18)

References

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