Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus

Yanbo YUAN; Zhaojuan RUAN; Liangju CAO; Wanjuan YANG; Yu JIANG; Xue ZHOU

doi:10.12259/j.issn.2095-610X.S20230720

Volume 44 Issue 7

Jul. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 125-129

Yanbo YUAN, Zhaojuan RUAN, Liangju CAO, Wanjuan YANG, Yu JIANG, Xue ZHOU. Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(7): 125-129. doi: 10.12259/j.issn.2095-610X.S20230720

Citation:

Yanbo YUAN, Zhaojuan RUAN, Liangju CAO, Wanjuan YANG, Yu JIANG, Xue ZHOU. Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(7): 125-129. doi: 10.12259/j.issn.2095-610X.S20230720

Citation:

Yanbo YUAN, Zhaojuan RUAN, Liangju CAO, Wanjuan YANG, Yu JIANG, Xue ZHOU. Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(7): 125-129. doi: 10.12259/j.issn.2095-610X.S20230720

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Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20230720

1.
Dept. of Stomatology，Kunming 1st People’s Hospital ，Kunming Yunnan 650011
2.
Dept. of Endocrinology，The 92nd Hospital of the Joint Logistic Support Force of the PLA ， Kunming Yunnan 650032，China

Received Date: 2022-12-16
Available Online: 2023-07-10
Publish Date: 2023-07-25

Abstract

Abstract

Objective To study the growth factors and its contents in the concentrated growth factor （CGF） fibrin gel for type 2 diabetes mellitus （T2DM）. Methods T2DM patients who needed tooth extraction and implantation under insulin hypoglycemic were selected and grouped according to the hemoglobin A 1 c （HbA1c） results, peripheral blood was drawn and centrifuged to obtain CGF. In samples, TGF-β1, EGF, OPG, PDGF-BB, VEGF, IGF-1, BMP-2, Bfgf, TNF-αand IL-1βwere tested by enzyme-linked immunosorbent assay （ELISA）. Results The CGF gels from insulin-controlled T2DM patients contained the same 10 growth factors as those from healthy controls. There was no significant difference in the content of OPG in T2DM patients with good and moderate insulin control compared with the healthy control group （P > 0.05）. There were significant differences from the poorly controlled groups （P < 0.05）. The content of partial growth factors （TGF-1, EGF） of T2DM patients in different groups was lower than that of healthy controls （P < 0.05）. There was no significant difference in the contents of some growth factors （PDGF-BB, VEGF, IGF-1, BMP-2, bFGF, TNF-αand IL-1β） between the observation group and healthy control group （P > 0.05）. Conclusion The CGF fibrin gel of insulin-controlled T2DM patients contains a variety of growth factors, which can stimulate cell proliferation, migration and differentiation, improve bone formation quality, and promote soft and hard tissue healing, with strong regeneration and repair potential functions.
- Type 2 diabetes mellitus,
- Concentrated growth factor,
- Active factors,
- ELISA

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References(21)

References

[1]	Borgnakke W S. IDF diabetes atlas:Diabetes and oral health-a two-way relationship of clinical importance[J]. Diabetes Res Clin Pract,2019,11(157):107839-107858.
[2]	Li Y,Teng D,Shi X,et al. Prevalence of diabetes recorded in maidland China using 2018 diagnostic criteria from the American Diabetes Association: National cross sectional study[J]. BMJ,2020,4(369):m997.
[3]	Rhys W, Stephen C, Joe C, et al. IDF Atlas 9th Edition 2019[M]. 9th ed. Brussels, Belgium: International Diabetes Federation, 2019: 45.
[4]	Monje A,Catena A,Borgnakke W S. Association between diabetes mellitus/hyperglycemia and peri-implant diseases:Systematic review and meta-analysis[J]. Journal of Clinical Periodontology,2017,44(6):636-648. doi: 10.1111/jcpe.12724
[5]	Chrcanovic B,Albrektsson T,Wennerberg A. Diabetes and oral implant failure: A systematic review[J]. J Dent Res,2014,93(9):859-867. doi: 10.1177/0022034514538820
[6]	陈亚楠,李文晋,李鹏翠. 浓缩生长因子在拔牙后牙槽嵴位点保存中应用的 meta 分析[J]. 临床口腔医学杂志,2022,38(6):367-371. doi: 10.3969/j.issn.1003-1634.2022.06.014
[7]	陈晖璐,郭彦君,唐海洋,等. 浓缩生长因子对受损周围神经影响的实验研究[J]. 临床口腔医学杂志,2020,36(5):270-274. doi: 10.3969/j.issn.1003-1634.2020.05.005
[8]	Sema K,Zihni C K,Vakur O. The effect of concentrated growth factor on calvarial bone in diabetic healingreview[J]. J Craniofac Surg,2020,31(1):158-161. doi: 10.1097/SCS.0000000000006087
[9]	Wang X Y,Tong S H Q,Huang S H Y,et al. Application of a new type of natural calcined bone repair material combined with concentrated growth factors in bone regeneration in rabbit critical-sized calvarial defect[J]. Biomed Res Int,2020,2020(11):8810747-8810753.
[10]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 中华糖尿病杂志,2021,13(4):315-409.
[11]	韩尚志,兰玲莉,刘锐,等. CGF、PRF 和 PRP 中各种生长因子定量分析[J]. 河北医药,2022,44(2):184-187. doi: 10.3969/j.issn.1002-7386.2022.02.005
[12]	齐喜娟. 富自体浓缩生长因子纤维蛋白凝胶（液体）活性因子及其含量分析[D]. 石家庄: 河北医科大学, 2014.
[13]	Mijiritsky E,Assaf H D,Peleg O,et al. Use of PRP,PRF and CGF in periodontal regeneration and facial rejuvenation-A narrative review[J]. Biology (Basel),2021,10(4):317-340. doi: 10.3390/biology10040317
[14]	Lili Z,Hongjun A. Concentrated growth factor promotes proliferation,osteogenic differentiation,and angiogenic potential of rabbit periosteum-derived cells in vitro[J]. J Dent Health Oral Disord Ther,2019,14(1):146-156.
[15]	Takahashi A,Tsujino T,Yamaguchi S,et al. Distribution of platelets,transforming growth factor-β1,platelet-derived growth factor-BB,vascular endothelial growth factor and matrix metalloprotease-9 in advanced platelet-rich fibrin and concentrated growth factormatrices[J]. J Investig Clin Dent,2019,10(4):e12458.
[16]	Napoli N,Chandran M,Pierroz D D,et al. Mechanisms of diabetes mellitus-induced bone fragility[J]. Nat Rev Endocrinol,2017,13(4):208-219.
[17]	Raju K, Mani U M, Vaidyanathan A K. Evaluating the osteogenic potential of insulin-like growth factor-1 microspheres on osteoblastic activity around dental implants in patients with type 2 diabetes mellitus using bone scintigraphy: A split-mouth randomized controlled trial[J/OL]. J Prosthet Dent, 2023, 129（4）: 561-565.
[18]	Hernandez M,Baeza M,Contreras J,et al. MMP-8,TRAP-5,and OPG levels in GCF diagnostic potential to discriminate between healthy patients’,mild and severe periodontitis sites[J]. Biomolecules,2020,10(11):1500-1509. doi: 10.3390/biom10111500
[19]	PryStaz K,Kaiser K,Kovtun A,et a1. Distinct effects of IL-6 classic and trans-signaling in bone fracture healing[J]. The American Joumal of Pathology,2018,188(2):474-490. doi: 10.1016/j.ajpath.2017.10.011
[20]	Gomes A M,Douglasdeoliveira D W,Ferreira S D,et al. Periodontal disease,peri-implant disease andlevels of salivary biomarkers IL-1β,IL-10,RANK,OPG,MMP-2,TGF-β and TNF-α: follow-up over5 years[J]. Journal of Applied Oral Science,2019,72(11):1498-1508.
[21]	Gidding S S,Bacha F,Bjornstad P,et al. Cardiacbiomarkers in youth with type 2 diabetes mellitus: Results from the today study[J]. The Journal of Pediatrics,2018,192:86-92.

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