Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer

Dongyang ZHANG; Zheng LI; Yahong WANG; Guangshun LIU; Yuhang QUAN; Xiang MA

doi:10.12259/j.issn.2095-610X.S20230721

Volume 44 Issue 7

Jul. 2023

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Dongyang ZHANG, Zheng LI, Yahong WANG, Guangshun LIU, Yuhang QUAN, Xiang MA. Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer[J]. Journal of Kunming Medical University, 2023, 44(7): 113-118. doi: 10.12259/j.issn.2095-610X.S20230721

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Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer

doi: 10.12259/j.issn.2095-610X.S20230721

1.
Dept. of Anesthesiology
2.
Dept. of Gynecologic Oncology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2023-04-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To investigate the effects of combined subanesthetic doses of esketamine and propofol anesthesia in three-dimensional after loading treatment of cervical cancer. Methods One hundred patients who received three-dimensional afterloading treatment for cervical cancer in our hospital between February 2022 and January 2023 were randomly divided into two groups, with 50 cases in each group. Patients in the control S group received Sulfentany combined with propofol for anesthesia, while those in the experimental E group received esketamine together with propofol. The duration of surgery, wake-up time, the incidence of intraoperative respiratory adverse events, the incidence of postoperative adverse events, changes in vital signs at the same time point, and a self-reported satisfaction survey were recorded for both groups of patients. Results There was no significant difference between the two groups in terms of operation time and wake-up time （P > 0.05）. The effects of anesthetic and time on heart rate （HR）, mean arterial pressure （MAP）, and oxygen saturation （SpO ₂） were analyzed by two-way ANOVA. It was found that HR was higher in the E group than in the S group （F = 12.353, P = 0.001）, and the HR differed significantly at different times （F = 6.637, P = 0.002）. The MAP was also significantly higher in the E group compared with the S group （F = 11.245, P = 0.001）, and also differed at different times （F = 17.023, P < 0.001）, although there were no interactive effects between group and time （ F = 1.861, P = 0.159）. Both group and time were observed to affect the SpO₂, which was higher in the E group than in the S group （F = 4.960, P = 0.027） and also differed significantly at different times （F = 183.045, P < 0.001）, although no interactive effects between group and time were observed （ F = 0.054, P = 0.947）. No significant differences in the visual analog scale （VAS） scores were found between the two groups at different time points （P > 0.05）, and both anesthesia methods had good analgesic effects. In terms of intraoperative adverse events, the incidence of hypotension （MAP ≤65 mmHg） or a decrease in blood pressure of ≥20% and requirements for vasoactive drug administration during surgery were lower in the E group than in the S group （ P < 0.05）, while the incidence of psychiatric symptoms was higher in the E group than in the S group （ P < 0.05）. As shown by the self-reported anesthesia satisfaction survey, all 100 patients were satisfied with the anesthesia, with no significant difference in the satisfaction rates between the two groups （ P > 0.05）. Conclusions The combination of subanesthetic doses of esketamine and propofol anesthesia in the three-dimensional after loading treatment of cervical cancer resulted in stable hemodynamics, good analgesic effect, and patient satisfaction. However, the incidence of postoperative psychiatric symptoms was higher compared to the control group.
- Subanesthetic,
- Esketamine,
- Propofol,
- Three-dimensional after loading treatment,
- Cervical cancer

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References

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