Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer

Dongyang ZHANG; Zheng LI; Yahong WANG; Guangshun LIU; Yuhang QUAN; Xiang MA

doi:10.12259/j.issn.2095-610X.S20230721

Volume 44 Issue 7

Jul. 2023

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Yuxin XIONG, Ying YANG. Research Progress of Diabetic Tubulopathy[J]. Journal of Kunming Medical University, 2023, 44(9): 148-154. doi: 10.12259/j.issn.2095-610X.S20230920

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Dongyang ZHANG, Zheng LI, Yahong WANG, Guangshun LIU, Yuhang QUAN, Xiang MA. Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer[J]. Journal of Kunming Medical University, 2023, 44(7): 113-118. doi: 10.12259/j.issn.2095-610X.S20230721

Yuxin XIONG, Ying YANG. Research Progress of Diabetic Tubulopathy[J]. Journal of Kunming Medical University, 2023, 44(9): 148-154. doi: 10.12259/j.issn.2095-610X.S20230920

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Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer

doi: 10.12259/j.issn.2095-610X.S20230721

1.
Dept. of Anesthesiology
2.
Dept. of Gynecologic Oncology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2023-04-17
Publish Date: 2023-07-25

Abstract

Abstract

Objective To investigate the effects of combined subanesthetic doses of esketamine and propofol anesthesia in three-dimensional after loading treatment of cervical cancer. Methods One hundred patients who received three-dimensional afterloading treatment for cervical cancer in our hospital between February 2022 and January 2023 were randomly divided into two groups, with 50 cases in each group. Patients in the control S group received Sulfentany combined with propofol for anesthesia, while those in the experimental E group received esketamine together with propofol. The duration of surgery, wake-up time, the incidence of intraoperative respiratory adverse events, the incidence of postoperative adverse events, changes in vital signs at the same time point, and a self-reported satisfaction survey were recorded for both groups of patients. Results There was no significant difference between the two groups in terms of operation time and wake-up time （P > 0.05）. The effects of anesthetic and time on heart rate （HR）, mean arterial pressure （MAP）, and oxygen saturation （SpO ₂） were analyzed by two-way ANOVA. It was found that HR was higher in the E group than in the S group （F = 12.353, P = 0.001）, and the HR differed significantly at different times （F = 6.637, P = 0.002）. The MAP was also significantly higher in the E group compared with the S group （F = 11.245, P = 0.001）, and also differed at different times （F = 17.023, P < 0.001）, although there were no interactive effects between group and time （ F = 1.861, P = 0.159）. Both group and time were observed to affect the SpO₂, which was higher in the E group than in the S group （F = 4.960, P = 0.027） and also differed significantly at different times （F = 183.045, P < 0.001）, although no interactive effects between group and time were observed （ F = 0.054, P = 0.947）. No significant differences in the visual analog scale （VAS） scores were found between the two groups at different time points （P > 0.05）, and both anesthesia methods had good analgesic effects. In terms of intraoperative adverse events, the incidence of hypotension （MAP ≤65 mmHg） or a decrease in blood pressure of ≥20% and requirements for vasoactive drug administration during surgery were lower in the E group than in the S group （ P < 0.05）, while the incidence of psychiatric symptoms was higher in the E group than in the S group （ P < 0.05）. As shown by the self-reported anesthesia satisfaction survey, all 100 patients were satisfied with the anesthesia, with no significant difference in the satisfaction rates between the two groups （ P > 0.05）. Conclusions The combination of subanesthetic doses of esketamine and propofol anesthesia in the three-dimensional after loading treatment of cervical cancer resulted in stable hemodynamics, good analgesic effect, and patient satisfaction. However, the incidence of postoperative psychiatric symptoms was higher compared to the control group.
- Subanesthetic,
- Esketamine,
- Propofol,
- Three-dimensional after loading treatment,
- Cervical cancer

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References(19)

References

[1]	Zheng R,Zhang S,Zeng H,et al. Cancer incidence and mortality in China,2016[J]. Journal of the National Cancer Center,2022,2(1):1-9. doi: 10.1016/j.jncc.2022.02.002
[2]	贾怡童,罗芳. “舒适化医疗”的发展与医学伦理学的关系[J]. 医学与哲学(B),2017,38(5):86-88.
[3]	贾涛,滕金亮. 新型麻醉镇痛药: 艾司氯胺酮[J]. 中国临床药理学与治疗学,2022,27(7):834-840.
[4]	周辉,王东雁,罗铭,等. 《FIGO 2021 妇癌报告》——子宫颈癌指南解读[J]. 中国使用妇科与产科杂志,2022,38(5):538-544.
[5]	Jonkman K,van Rijnsoever E,Olofsen E,et al. Esketamine counters opioid-induced respiratory depression[J]. Br J Anaesth,2018,120(5):1117-1127. doi: 10.1016/j.bja.2018.02.021
[6]	Lei C,Huang M,Li N,et al. Intensity-modulated radiotherapy combined with intracavitary brachytherapy for locally advanced cervical cancer with uterus didelphys[J]. Gynecol Oncol Rep,2021,36:100724. doi: 10.1016/j.gore.2021.100724
[7]	张维帅,高玉华,卢庆刚,等. 全身麻醉与局部麻醉在局部晚期宫颈癌腔内联合组织间插植放疗中剂量比较[J]. 临床军医杂志,2022,50(4):430-433.
[8]	袁静静,陈书涵,谢艳乐,等. 亚麻醉剂量艾司氯胺酮对胸腔镜手术后阿片类药物镇痛消耗量的影响[J]. 中华医学杂志,2022,102(15):1108-1113.
[9]	万幸,杨青青,樊迪,等. 亚麻醉剂量艾司氯胺酮复合丙泊酚应用于无痛胃肠镜检查的效果[J]. 临床麻醉学杂志,2022,38(2):144-148.
[10]	Eberl S,Koers L,van Hooft J E,et al. Sedation with propofol during ERCP: is the combination with esketamine more effective and safer than with alfentanil? Study protocol for a randomized controlled trial[J]. Trials,2017,18(1):472. doi: 10.1186/s13063-017-2197-8
[11]	钱夏丽,夏凡,沈晓凤,等. 艾司氯胺酮复合丙泊酚在宫腔镜检查术中的应用[J]. 临床麻醉学杂志,2021,37(7):706-708.
[12]	陈晓红,李萌萌,解群. 右旋氯胺酮的药理学特征及其与阿片类药物联合应用的研究进展[J]. 感染、炎症、修复,2021,22(3):183-185.
[13]	王晓东,于明涛,刘子强,等. 苯磺酸瑞马唑仑联合艾司氯胺酮静脉麻醉在内镜下逆行胰胆管造影术中的临床应用[J]. 中国医刊,2021,56(3):274-277.
[14]	Zhang F,Ding J,Luo M,et al. Effects of subanesthesia dose S‐ketamine induction on postoperative psychiatric complications after gynecological surgery[J]. Ibrain,2022,8(2):165-175. doi: 10.1002/ibra.12039
[15]	Mihaljević S,Pavlović M,Reiner K,et al. Therapeutic mechanisms of ketamine[J]. Psychiatr Danub,2020,32(3-4):325-333. doi: 10.24869/psyd.2020.325
[16]	李艳丽,王振山,李晓娟,等. 艾司氯胺酮在临床麻醉中的研究进展[J]. 医学理论与实践,2023,36(5):756-758.
[17]	陈盛岚,朱翔,赵江峰,等. 丙泊酚联合艾司氯胺酮在无痛胃肠镜检查中的应用效果[J]. 中国医学创新,2022,19(5):74-77.
[18]	Trujillo K A,Heller C Y. Ketamine sensitization: Influence of dose,environment,social isolation and treatment interval[J]. Behav Brain Res,2020,378:112271. doi: 10.1016/j.bbr.2019.112271
[19]	丁钦,解成兰,岳苏阳,等. 艾司氯胺酮临床应用研究进展[J]. 实用药物与临床,2022,25(8):754-758.

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