Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn

Ling ZHAO; Shulan JIAO; Yongyu SI; Liu YANG; Yinghui BU

doi:10.12259/j.issn.2095-610X.S20230725

Volume 44 Issue 7

Jul. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(7): 100-104

Ling ZHAO, Shulan JIAO, Yongyu SI, Liu YANG, Yinghui BU. Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn[J]. Journal of Kunming Medical University, 2023, 44(7): 100-104. doi: 10.12259/j.issn.2095-610X.S20230725

Citation:

Ling ZHAO, Shulan JIAO, Yongyu SI, Liu YANG, Yinghui BU. Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn[J]. Journal of Kunming Medical University, 2023, 44(7): 100-104. doi: 10.12259/j.issn.2095-610X.S20230725

Citation:

PDF( 621 KB)

Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn

doi: 10.12259/j.issn.2095-610X.S20230725

1.
Dept. of Anesthesiology
2.
Dept. of Pharmacy，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2023-05-08
Available Online: 2023-07-10
Publish Date: 2023-07-25

Abstract

Abstract

Objective To investigate the pharmacokinetics of dexmedetomidine in burn patients with different degrees in order to improve the quality of anesthesia in burn patients. Methods Forty-five burn patients undergoing elective surgery were selected in this study. Among them, patients undergoing scar excision and skin grafting were included in group A, and patients with moderate and severe burns were respectively included in group B and group C, with 15 cases in each group. Patients in the three groups were respectively pumped dexmedetomidine 1µg/kg intravenously at a constant rate 10min before anesthesia induction. Before dexmedetomidine administration, during the administration of 1 （TCI1）, 3 （TCI3）, 5 （TCI5） and 10 （TCI10）min, after discontinuation of 2 （T2）, 5 （T5）, 10 （T10）, 15 （T15）, 20 （T20）, 25 （T25）, 30 （T30）, 45 （T45）, 60 （T60）, 90 （T90）, 120 （T120） min, we collected the arterial blood, and determined the plasma drug concentration （Cm） of dexmedetomidine. At last, we calculated the pharmacokinetic parameters. Results The Vd CL, K12, and K10 in group C were all higher than those in group A, the Vd, CL in group C were higher than those in group B, and the Vd in group B was higher than that in group A. Conclusions In severe burn patients, the Vd, CL, K12, and K10 of dexmedetomidine are increased, and Cm is decreased. The dose of dexmedetomidine can be appropriately increased to improve the quality of anesthesia and reduce complications.
- Burn,
- Dexmedetomidine,
- Pharmacokinetic

FullText(HTML)

References(17)

References

[1]	Snell J A,Loh N H,Mahambrey T,et al. Clinical review: the critical care management of the burn patient[J]. Critical Care,2013,17(5):241-242. doi: 10.1186/cc12706
[2]	李芸芸,龚孝春. 右美托咪定复合氟比洛芬酯对重度烧伤患者全身麻醉苏醒期应激因子及血糖的影响[J]. 中国处方药,2018,16(9):67-68. doi: 10.3969/j.issn.1671-945X.2018.09.042
[3]	覃凤均,陈忠,卞婧,等. 大面积严重烧伤患者休克期应用亚胺培南药代动力学研究[J]. 临床军医杂志,2022,50(6):595-598.
[4]	肖如红,张忠,米志华. PI3K/Akt 信号传导通路在右美托咪定抗大鼠肢端缺血/再灌注致急性肺损伤中的作用[J]. 北方药学,2017,14(1):140-141. doi: 10.3969/j.issn.1672-8351.2017.01.120
[5]	Dalley A J,Deans R,Lipman J. Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury[J]. Antimicrob Agents Chemother,2009,53(12):5303-5305. doi: 10.1128/AAC.01600-08
[6]	邹磊. 右美托咪定对大面积烧伤切痂植皮患者麻醉效果及应激反应的影响[J]. 中国烧伤创疡杂志,2020,32(1):33-37. doi: 10.3969/j.issn.1001-0726.2020.01.007
[7]	代涛,李延仓,娄季鹤,等. 不同镇痛镇静模式在严重烧伤患者回收期应用效果分析[J]. 新乡医学院学报,2020,37(1):44-47.
[8]	Farag E,Argalious M,Abd-Elsayed A. The use of dexmedetomidine in anesthesia and intensive care: A review[J]. Current Pharmaceutical Design,2012,18(38):6257-6265. doi: 10.2174/138161212803832272
[9]	赵秀洁,王业文,宋倩倩,等. 右美托咪定药理作用及肺保护作用机制的研究进展[J]. 中国医学创新,2022,19(33):185-188. doi: 10.3969/j.issn.1674-4985.2022.33.042
[10]	Zhang T,Deng Y,He P. Effects of mild hypoalbuminemia on the pharmacokinetics and pharmacodynamics of dexmedetomidine in patients after major abdominal or thoracic surgery[J]. Journal of Clinical Anesthesia,2015,27(8):632-637. doi: 10.1016/j.jclinane.2015.06.002
[11]	Li B L,Zhang N,Huang J X. A comparison of intranasal dexmedetomidine for sedation in children administered either by atomiser or by drops[J]. Anaesthesia,2016,71(5):522-528. doi: 10.1111/anae.13407
[12]	李湘燕,吕媛. 低蛋白血症对危重症患者抗菌药物疗效的影响[J]. 中华结核和呼吸杂志,2018,41(8):600-603.
[13]	Bonate P L. Pathophysiology and pharmacokinetics following burn injury[J]. Clin Pharmacokinetics,1990,18(5):118-130.
[14]	杨洁, 黄英姿. 重症感染患者病情严重程度对抗菌药物表观分布容积的影响因素分析[J/OL]. 中华重症医学电子杂志, 2019, 5（3）: 282-285.
[15]	Blanchet B T,Jullien V T,Vinsonneau C E. Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients[J]. Clin Pharmacokinetics,2008,47(10):635-654. doi: 10.2165/00003088-200847100-00002
[16]	Benet L. Changes in plasma protein binding have little clinical relevance[J]. Clin Pharmacol Ther,2002,71(3):115-121. doi: 10.1067/mcp.2002.121829
[17]	Dutta S,Lal R,Karol M D. Influence of cardiac output on dexmedetomidine pharmacokinetics[J]. Pharm Sci,2000,89(4):519-527. doi: 10.1002/(SICI)1520-6017(200004)89:4<519::AID-JPS9>3.0.CO;2-U

Relative Articles(20)

Relative Articles

[1]	Baochuan HUANG, Wuquan LI, Yi TANG. An Epidemiological Analysis of 1500 Pediatric BurnsPatients at the Burn Center in Yunnan. Journal of Kunming Medical University, 2024, 45(10): 1-9.
[2]	Hongmei BAO, Rong QIN, Yu ZHANG, Meiju YANG, Gang SU. Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy. Journal of Kunming Medical University, 2024, 45(9): 110-115. doi: 10.12259/j.issn.2095-610X.S20240917
[3]	Wei CHEN, Zichen ZHANG, Ruoyu WANG, He JIANG, Wende CAO, Yulan MIAO. Analysis of Clinical Data of 471 Elderly Patients Hospitalized with Burns. Journal of Kunming Medical University, 2023, 44(2): 88-97. doi: 10.12259/j.issn.2095-610X.S20230202
[4]	Rong QIN, Gang SU, Yu ZHANG, Wei YIN, zhen ZHAO. Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy. Journal of Kunming Medical University, 2023, 44(2): 156-160. doi: 10.12259/j.issn.2095-610X.S20230215
[5]	Yue LU, Changming QIU, Yunli YANG, Zhiguo HUANG, Zhigui LI, Weiqing MA, Na LI. Analgesia of Ultrasound-guided Single-dose Adductor Canal Block with Dexmedetomidine Combined with Ropivacaine after Patella Fracture Surgery in Adults. Journal of Kunming Medical University, 2022, 43(6): 68-73. doi: 10.12259/j.issn.2095-610X.S20220613
[6]	Zhao-sen FENG, Yu FANG, Ding-qin OU, Yi-han YANG, Zhi-yao WANG, Jie HUANG. Clinical Effect of Dexmedetomidine and Dexamethasone as Adjuvants for Brachial Plexus Block. Journal of Kunming Medical University, 2021, 42(10): 68-75. doi: 10.12259/j.issn.2095-610X.S20211005
[7]	Yan CAO, Hong-yan JIANG, Yan-xue WANG, Dou-wei WU, Chuan-yun QIAN, Hai-ying WU, Ping LI. Dexmedetomidine Inhibits Neuronal Apoptosis after Traumatic Brain Injury in Rats. Journal of Kunming Medical University, 2021, 42(2): 1-5. doi: 10.12259/j.issn.2095-610X.S20210202
[8]	Yuan YANG, Li-jia PENG, Lan-qing PU, Jun-jie LI, Jian-lin SHAO, Xin YANG. Application of Propofol Combined with Dexmedetomidine or Midazolam in Painless Gastrointestinal Endoscopy in the Elderly. Journal of Kunming Medical University, 2021, 42(2): 43-48. doi: 10.12259/j.issn.2095-610X.S20210221
[9]	Feng YUANG, Shu-lan JIAO, Rui CHEN, Bing-bing XIANG, Yong-yu SI. Pharmacokinetics of Etomidate in Patients with Different Degrees of Burn. Journal of Kunming Medical University, 2021, 42(6): 94-97. doi: 10.12259/j.issn.2095-610X.S20210637
[10]	Mai-qiao YANG, Fu-rong ZHANG, Li-li LIU, Xiao-ying LIU, ping LIU. Clinical Effect of Dexmedetomidine on Shivering Reaction in Cesarean Section Patients during Combined Spinal-epidural Anesthesia. Journal of Kunming Medical University, 2020, 41(11): 98-102. doi: 10.12259/j.issn.2095-610X.S20201125
[11]	Qing-qing XIONG, Xiao-dong LUO, Bu-fang FU, Jia-yi ZHONG, Guo-lian HE. Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas. Journal of Kunming Medical University, 2020, 41(12): 85-88. doi: 10.12259/j.issn.2095-610X.S20201224
[12]	Liu YANG, Qi-cai QU, Rui CHEN, Shu-lan JIAO, Yong-yu SI, Hua ZHOU. Effects of Dexmedetomidine on Inflammatory Response in Rats with Smoke Inhalation Lung Injury. Journal of Kunming Medical University, 2020, 41(11): 30-37. doi: 10.12259/j.issn.2095-610X.S20201124
[13]	Yang Yue, Tao Jian Ping . . Journal of Kunming Medical University, 2019, 40(12): 135-139.
[14]	Wang Xing Yao , Chen Jian Chun , Qu Qi Cai , Ou Yang Jie , Ma Jun , Zhou Chen . . Journal of Kunming Medical University, 2018, 39(11): 35-38.
[15]	Xiao Qun Wen , Yang Long , He Xiang Ying , Li Qi , You Jun . Research of the Pharmacokinetics and Pharmacodynamics of Torasemide in the Treatment of Children Patients with Acute Heart Failure. Journal of Kunming Medical University, 2018, 39(05): 66-69.
[16]	Duan Er Yun , Jiao Shu Lan , Yang Jian . . Journal of Kunming Medical University, 2018, 39(10): 79-83.
[17]	Li Wen Feng , Fan Xiao Hua , Dong Fa Tuan , Li Na . . Journal of Kunming Medical University, 2017, 38(02): 118-121.
[18]	Song Shi Qin . Influence of Dexmedetomidine on the Oxygenation and Cardio-pulmonary Function of Elderly Patients with Surgery. Journal of Kunming Medical University, 2017, 38(07): 122-125.
[19]	Dan Ke Ji . . Journal of Kunming Medical University,
[20]	Zhang Meng Si . . Journal of Kunming Medical University,