MSCs Promote Autophagy to Alleviate Liver Injury in NASH by Regulating AMPK/mTOR Axis

Chenchen LIANG; Jianpeng GAO

doi:10.12259/j.issn.2095-610X.S20230728

Volume 44 Issue 7

Jul. 2023

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Chenchen LIANG, Jianpeng GAO. MSCs Promote Autophagy to Alleviate Liver Injury in NASH by Regulating AMPK/mTOR Axis[J]. Journal of Kunming Medical University, 2023, 44(7): 162-167. doi: 10.12259/j.issn.2095-610X.S20230728

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Chenchen LIANG, Jianpeng GAO. MSCs Promote Autophagy to Alleviate Liver Injury in NASH by Regulating AMPK/mTOR Axis[J]. Journal of Kunming Medical University, 2023, 44(7): 162-167. doi: 10.12259/j.issn.2095-610X.S20230728

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MSCs Promote Autophagy to Alleviate Liver Injury in NASH by Regulating AMPK/mTOR Axis

doi: 10.12259/j.issn.2095-610X.S20230728

Chenchen LIANG¹,
Jianpeng GAO^{2
,
,}

1.
School of Public Health，Dali University，Dali Yunnan 671013
2.
Administration Section，Yan’an Hospital，Kunming Yunnan 650041，China

Received Date: 2023-05-16
Available Online: 2023-08-08
Publish Date: 2023-07-25

Abstract

Abstract

NASH is the characteristic pathological manifestation of the liver in MAFLD, which is a key turning point in the development of MAFLD from a relatively benign and reversible stage to liver injury and even cirrhosis and hepatocellular carcinoma. Recent studies have shown that lipid deposition and oxidative stress run through MAFLD metabolic diseases, and improving hepatic lipid deposition and oxidative stress is the main intervention approach for the treatment and prevention of NASH disease. In general, promoting autophagy levels can reduce triglyceride （TG） accumulation and oxidative stress （OS） and promote hepatocyte survival, while blocking autophagy levels may accelerate the progression of NASH. However, the activation of autophagy levels is closely related to the activation of upstream signals AMPK/mTOR/ULK1 and the regulation of EI24. EI24, an essential autophagy protein closely related to the activation of AMPK and mTOR protein channels, can accelerate the activation of autophagy flow by promoting the degradation process of autophagy-lysosome. Meanwhile, mesenchymal stem cells （MSCs） as ideal autophagy inducers have been widely studied for their excellent therapeutic effects in treating various inflammatory diseases such as NAFLD through the activation of AMPK/mTOR-mediated autophagy. Therefore, “drug-acting” mesenchymal stem cells should be used to regulate the activation of autophagy level of EI24/AMPK/mTOR to promote autophagy, inhibit adipogenesis and reduce lipid deposition, and effectively alleviate or reverse NASH liver injury, to provide a basis for elucidating the pathogenesis of NASH related diseases and developing new therapeutic strategies.
- NASH,
- MSCs,
- AMPK,
- mTOR,
- Autophagy

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References(55)

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