Research Progress of DNA Methylation and Schizophrenia

Wensa YIN; Yumei LU; Jinlian TONG; shengjie NIE; Ye RUAN

doi:10.12259/j.issn.2095-610X.S20230811

Volume 44 Issue 8

Aug. 2023

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Wensa YIN, Yumei LU, Jinlian TONG, shengjie NIE, Ye RUAN. Research Progress of DNA Methylation and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(8): 145-150. doi: 10.12259/j.issn.2095-610X.S20230811

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Wensa YIN, Yumei LU, Jinlian TONG, shengjie NIE, Ye RUAN. Research Progress of DNA Methylation and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(8): 145-150. doi: 10.12259/j.issn.2095-610X.S20230811

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Research Progress of DNA Methylation and Schizophrenia

doi: 10.12259/j.issn.2095-610X.S20230811

Wensa YIN^{1, 2, 3},
Yumei LU⁴,
Jinlian TONG^{1, 2, 3
,
,},
shengjie NIE⁵,
Ye RUAN^{1, 2, 3}

1.
Dept. of Medical Administration，The Psychiatric Hospital of Yunnan Province
2.
The Mental Health Prevention and Treatment Center of Yunnan Province
3.
The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
4.
School of Forensic Medicine，Kunming Medical University，Kunming Yunnan 650500
5.
Dept. of Postgraduate，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-06-11
Available Online: 2023-09-09
Publish Date: 2023-08-30

Abstract

Abstract

Schizophrenia is a mental disorder characterized by significant abnormalities in cognition, thinking, emotion, and behavior. It is one of the most common severe mental disorders and causes serious distress to individuals, families, and society. In recent years, epigenetic studies focusing on DNA methylation have been conducted to understand schizophrenia. This review summarizes the research progress on DNA methylation and schizophrenia in recent years, aiming to provide new insights and reference value for further research on schizophrenia.
- Schizophrenia,
- DNA methylation,
- MAOA gene,
- COMT gene,
- GAD1 gene

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References(50)

References

[1]	Fonseka L N,Woo B. Wearables in Schizophrenia: Update on Current and Future Clinical Applications[J]. JMIR Mhealth Uhealth,2022,10(4):356-362.
[2]	Sadeghi D,Shoeibi A,Ghassemi N,et al. An overview of artificial intelligence techniques for diagnosis of Schizophrenia based on magnetic resonance imaging modalities: Methods,challenges,and future works[J]. Comput Biol Med,2022,146:105-155.
[3]	Zamanpoor M. Schizophrenia in a genomic era: a review from the pathogenesis,genetic and environmental etiology to diagnosis and treatment insights[J]. Psychiatr Genet,2020,30(1):1-9. doi: 10.1097/YPG.0000000000000245
[4]	Cromby J,Chung E,Papadopoulos D,et al. Reviewing the epigenetics of schizophrenia[J]. J Ment Health,2019,28(1):71-79. doi: 10.1080/09638237.2016.1207229
[5]	Lisoway A J,Chen C C,Zai C C,et al. Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment[J]. Schizophr Res,2021,232:112-124. doi: 10.1016/j.schres.2021.05.010
[6]	Richetto J,Meyer U. Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability[J]. Biol Psychiatry,2021,89(3):215-226. doi: 10.1016/j.biopsych.2020.03.008
[7]	Khavari B,Cairns M J. Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers[J]. Cells,2020,9(8):1837-1864. doi: 10.3390/cells9081837
[8]	Wang M,Ngo V,Wang W. Deciphering the genetic code of DNA methylation[J]. Brief Bioinform,2021,22(5):424-434. doi: 10.1093/bib/bbaa424
[9]	Shirvani-Farsani Z,Maloum Z,Bagheri-Hosseinabadi Z,et al. DNA methylation signature as a biomarker of major neuropsychiatric disorders[J]. J Psychiatr Res,2021,141:34-49. doi: 10.1016/j.jpsychires.2021.06.013
[10]	Skvortsova K,Bogdanovic O. TAB-seq and ACE-seq Data Processing for Genome-Wide DNA hydroxymethylation Profiling[J]. Methods Mol Biol,2021,2272:163-178.
[11]	De Borre M,Branco M R. Oxidative Bisulfite Sequencing: An Experimental and Computational Protocol[J]. Methods Mol Biol,2021,2198:333-348.
[12]	Kouter K,Šalamon Arčan I,Videtič Paska A. Epigenetics in psychiatry: Beyond DNA methylation[J]. World J Psychiatry,2023,13(6):319-330. doi: 10.5498/wjp.v13.i6.319
[13]	Snajder R,Leger A,Stegle O,et al. pycoMeth: a toolbox for differential methylation testing from Nanopore methylation calls[J]. Genome Biol,2023,24(1):83-102. doi: 10.1186/s13059-023-02917-w
[14]	Shen L,Lv X,Huang H,et al. Genome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese[J]. E Bio Medicine,2021,72:103609-103618. doi: 10.1016/j.ebiom.2021.103609
[15]	Perzel Mandell K A,Eagles N J,Wilton R,et al. Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk[J]. Nat Commun,2021,12(1):5251-5263. doi: 10.1038/s41467-021-25517-3
[16]	Berdenis van Berlekom A,Notman N,Sneeboer M A,et al. DNA methylation differences in cortical grey and white matter in schizophrenia[J]. Epigenomics,2021,13(15):1157-1169. doi: 10.2217/epi-2021-0077
[17]	Chen J,Zang Z,Braun U,et al. Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function[J]. JAMA Psychiatry,2020,77(6):628-636. doi: 10.1001/jamapsychiatry.2019.4792
[18]	Jauhar S,Johnstone M,McKenna P J. Schizophrenia[J]. Lancet,2022,399(10323):473-486. doi: 10.1016/S0140-6736(21)01730-X
[19]	Blokhin I O,Khorkova O,Saveanu R V,et al. Molecular mechanisms of psychiatric diseases[J]. Neurobiol Dis,2020,146:105-136.
[20]	Wawrzczak-Bargieła A,Bilecki W,Maćkowiak M. Epigenetic Targets in Schizophrenia Development and Therapy[J]. Brain Sci,2023,13(3):426-447. doi: 10.3390/brainsci13030426
[21]	Ni P,Zhou C,Liang S,et al. YBX1-Mediated DNA Methylation-Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia[J]. Adv Sci (Weinh),2023,10(20):455-469.
[22]	Labonté B,Abdallah K,Maussion G,et al. Regulation of impulsive and aggressive behaviours by a novel lncRNA[J]. Mol Psychiatry,2021,26(8):3751-3764. doi: 10.1038/s41380-019-0637-4
[23]	Ikegame T,Bundo M,Okada N,et al. Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia[J]. Schizophr Bull,2020,46(6):1577-1586. doi: 10.1093/schbul/sbaa075
[24]	Gao S,Cheng J,Li G,et al. Catechol-O-methyltransferase gene promoter methylation as a peripheral biomarker in male schizophrenia[J]. Eur Psychiatry,2017,44:39-46. doi: 10.1016/j.eurpsy.2017.03.002
[25]	Hu Y,Li C,Wang Y,et al. Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior[J]. Int J Legal Med,2018,132(6):1537-1544. doi: 10.1007/s00414-018-1773-0
[26]	Magwai T,Shangase K B,Oginga F O,et al. DNA Methylation and Schizophrenia: Current Literature and Future Perspective[J]. Cells,2021,10(11):289-300.
[27]	Walton E,Liu J,Hass J,et al. MB-COMT promoter DNA methylation is associated with working-memory processing in schizophrenia patients and healthy controls[J]. Epigenetics,2014,9(8):1101-1107. doi: 10.4161/epi.29223
[28]	Ghit A,Assal D,Al-Shami A S,et al. GABA(A) receptors: structure,function,pharmacology,and related disorders[J]. J Genet Eng Biotechnol,2021,19(1):123-138. doi: 10.1186/s43141-021-00224-0
[29]	Zong L,Zhou L,Hou Y,et al. Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia[J]. J Psychiatr Res,2017,88:9-17. doi: 10.1016/j.jpsychires.2016.12.019
[30]	Linde J,Zimmer-Bensch G. DNA Methylation-Dependent dysregulation of GABAergic interneuron functionality in neuropsychiatric diseases[J]. Front Neurosci,2020,14:133-141. doi: 10.3389/fnins.2020.00133
[31]	Yamamoto Y,Kida H,Kagawa Y,et al. FABP3 in the anterior cingulate cortex modulates the methylation status of the glutamic acid decarboxylase (67) promoter region[J]. J Neurosci,2018,38(49):10411-10423. doi: 10.1523/JNEUROSCI.1285-18.2018
[32]	Tao R,Davis K N,Li C,et al. GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development,schizophrenia[J]. Mol Psychiatry,2018,23(6):1496-1505.
[33]	Hwang I,Ahn J Y. Dysregulation of epigenetic control contributes to schizophrenia-like behavior in Ebp1(+/-) mice[J]. Int J Mol Sci,2020,21(7):2609-2629. doi: 10.3390/ijms21072609
[34]	Fachim H A,Corsi-Zuelli F,Loureiro C M,et al. Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation[J]. Prog Neuropsychopharmacol Biol Psychiatry,2021,108:110-168.
[35]	Nieto R R,Carrasco A,Corral S,et al. BDNF as a biomarker of cognition in schizophrenia/psychosis: an updated review[J]. Front Psychiatry,2021,12:407-413.
[36]	Ho N F,Tng J,Wang M,et al. Plasticity of DNA methylation,functional brain connectivity and efficiency in cognitive remediation for schizophrenia[J]. J Psychiatr Res,2020,126:122-133. doi: 10.1016/j.jpsychires.2020.03.013
[37]	Ursini G,Cavalleri T,Fazio L,et al. BDNF rs6265 methylation and genotype interact on risk for schizophrenia[J]. Epigenetics,2016,11(1):11-23. doi: 10.1080/15592294.2015.1117736
[38]	Keller S,Errico F,Zarrilli F,et al. DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects[J]. Psychiatry Res,2014,220(3):1147-1150. doi: 10.1016/j.psychres.2014.08.022
[39]	Mohammadi A,Rashidi E,Amooeian V G. Brain,blood,cerebrospinal fluid,and serum biomarkers in schizophrenia[J]. Psychiatry Res,2018,265:25-38. doi: 10.1016/j.psychres.2018.04.036
[40]	Armstrong N C,Anderson R C,McDermott K W. Reelin: Diverse roles in central nervous system development,health and disease[J]. Int J Biochem Cell Biol,2019,112:72-75. doi: 10.1016/j.biocel.2019.04.009
[41]	Hattori M,Kohno T. Regulation of reelin functions by specific proteolytic processing in the brain[J]. J Biochem,2021,169(5):511-516. doi: 10.1093/jb/mvab015
[42]	Jossin Y. Reelin Functions,Mechanisms of action and signaling pathways during brain development and maturation[J]. Biomolecules,2020,10(6):964-995. doi: 10.3390/biom10060964
[43]	Dong E,Locci V,Gatta E,et al. N-phthalyl-l-tryptophan (RG108),like clozapine (CLO),induces chromatin remodeling in brains of prenatally stressed mice[J]. Mol Pharmacol,2019,95(1):62-69. doi: 10.1124/mol.118.113415
[44]	Saxena S,Maroju P A,Choudhury S,et al. Analysis of transcript levels of a few schizophrenia candidate genes in neurons from a transgenic mouse embryonic stem cell model overexpressing DNMT1[J]. Gene,2020,757:449-455.
[45]	Alfimova M V,Kondratiev N V,Golov A K,et al. Methylation of the reelin gene promoter in peripheral blood and its relationship with the cognitive function of schizophrenia patients[J]. Mol Biol (Mosk),2018,52(5):782-792.
[46]	Kho S H,Yee J Y,Puang S J,et al. DNA methylation levels of RELN promoter region in ultra-high risk,first episode and chronic schizophrenia cohorts of schizophrenia[J]. Schizophrenia (Heidelb),2022,8(1):81-90. doi: 10.1038/s41537-022-00278-0
[47]	Terry A V Jr,Callahan P M. α7 nicotinic acetylcholine receptors as therapeutic targets in schizophrenia: Update on animal and clinical studies and strategies for the future[J]. Neuropharmacology,2020,170:108053-108063. doi: 10.1016/j.neuropharm.2020.108053
[48]	Misiak B,Samochowiec J,Konopka A,et al. Clinical correlates of the NR3C1 gene methylation at various stages of psychosis[J]. Int J Neuropsychopharmacol,2021,24(4):322-332. doi: 10.1093/ijnp/pyaa094
[49]	Qing L,Liu L,Zhou L,et al. Sex-dependent association of mineralocorticoid receptor gene (NR3C2) DNA methylation and schizophrenia[J]. Psychiatry Res,2020,292:113318-113324. doi: 10.1016/j.psychres.2020.113318
[50]	Liu L,Hu Y,Lu Y,et al. Sex-dependent DNA hypermethylation of SLC6A4 in patients with schizophrenia[J]. Neurosci Lett,2022,769:136394-136399. doi: 10.1016/j.neulet.2021.136394

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