Volume 44 Issue 8
Aug.  2023
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Binbin MA, Ning WANG, Jianping LIU, Kaiquan ZHANG, Yongli GAO, Gaohui LI, Chen ZHANG. Risk Factors of Deep Vein Thrombosis after Soft Tissue Trauma of Lower Extremities[J]. Journal of Kunming Medical University, 2023, 44(8): 110-116. doi: 10.12259/j.issn.2095-610X.S20230817
Citation: Binbin MA, Ning WANG, Jianping LIU, Kaiquan ZHANG, Yongli GAO, Gaohui LI, Chen ZHANG. Risk Factors of Deep Vein Thrombosis after Soft Tissue Trauma of Lower Extremities[J]. Journal of Kunming Medical University, 2023, 44(8): 110-116. doi: 10.12259/j.issn.2095-610X.S20230817

Risk Factors of Deep Vein Thrombosis after Soft Tissue Trauma of Lower Extremities

doi: 10.12259/j.issn.2095-610X.S20230817
  • Received Date: 2023-06-10
    Available Online: 2023-09-09
  • Publish Date: 2023-08-30
  •   Objective  To retrospectively analyze the risk factors of deep vein thrombosis (DVT) in patients with soft tissue trauma of the lower extremities, and to provide reference for the prevention and treatment of DVT.   Methods  The general clinical data, trauma status, laboratory tests data, imaging data, clinical management information, complications, and other factors of patients with lower limb soft tissue trauma admitted to a single center from January 2020 to December 2021 were collected and statistically analyzed. The risk factors of lower limb soft tissue trauma complicated with DVT were analyzed.   Results  The incidence of deep vein thrombosis (DVT) in 363 patients with lower limb soft tissue trauma was 8.8%. DVT involved the iliac vein in 1 case, the femoral vein in 1 case, the popliteal vein in 3 cases, the posterior tibial vein in 3 cases, the peroneal vein in 3 cases, and the muscular veins in 31 cases. There were significant differences between the DVT group and the non-DVT group in terms of age, gender, smoking, alcohol consumption, heart disease, type and severity of trauma, hemoglobin, fibrin degradation products (FDP), D-dimer, waiting time for admission, lack of prophylactic anticoagulation, post-traumatic local infection, and soft tissue defects (P < 0.05). Multivariate logistic regression analysis showed that age, smoking, post-traumatic local infection, waiting time for admission, lack of prophylactic anticoagulation, severity of trauma, and elevated D-dimer ( > 0.5 μg/mL) were independent risk factors for DVT after lower limb soft tissue trauma (P < 0.05).   Conclusion  DVT following soft tissue trauma of the lower limb mainly involves the intermuscular veins. Age, smoking history, local infection after trauma, waiting time for admission, unprotected anticoagulation, severity of trauma, and elevated D-dimer ( > 0.5 μg/mL) is closely related to the occurrence of DVT.
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  • [1]
    中华医学会呼吸病学分会肺栓塞与肺血管病学组. 肺血栓栓塞症诊治与预防指南[J]. 中华医学杂志,2018,98(14):1060-1087.
    [2]
    Kearon C. Natural history of venous thromboembolism[J]. Circulation, 2003 , 107(23 Suppl 1): I22-130.
    [3]
    Galanaud J P, Monreal M, Kahn S R. Epidemiology of the post-thrombotic syndrome[J]. Thromb Res, 2018 , 164: 100-109.
    [4]
    Geerts W H, Heit J A, Clagett G P, et al. Prevention of venous thromboembolism[J]. Chest, 2001 , 119(1 Suppl): 132S-175S.
    [5]
    Geerts W H, Pineo G F, Heit J A, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy[J]. Chest, 2004, 126(3 Supp l): 338S-400S.
    [6]
    Bates S M, Jaeschke R, Stevens S M, et al. Diagnosis of DVT: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines[J]. Chest, 2012 , 141(2 Suppl): e351S-e418S.
    [7]
    中华医学会骨科学分会创伤骨科学组,等. 中国创伤骨科患者围手术期静脉血栓栓塞症预防指南(2021)[J]. 中华创伤骨科杂志,2021,23(3):185-192. doi: 10.3760/cma.j.cn115530-20201228-00795
    [8]
    Dauzat M,Laroche J P. Diagnosis of acute lower limb deep venous thrombosis with ultrasound: trends and controversies[J]. J Clin Ultrasound,1997,25(7):343-358. doi: 10.1002/(SICI)1097-0096(199709)25:7<343::AID-JCU1>3.0.CO;2-A
    [9]
    龙安华. 下肢骨折患者静脉血栓栓塞症流行病学研究初步分析[D]. 天津: 南开大学, 2015.
    [10]
    陆芸,马宝通,郭若霖,等. 骨科创伤患者深静脉血栓危险因素的研究[J]. 中华骨科杂志,2007,27(9):693-698.
    [11]
    吕波,薛锋,唐果,等. 下肢骨折后深静脉血栓形成的影响因素分析[J]. 国际骨科学杂志,2018,39(6):373-377.
    [12]
    Hofmann L V, Kuo W T. Catheter-directed thrombolysis for acute DVT[J]. Lancet, 2012, 379(9810): 3-4.
    [13]
    Qiu T,Zhang T,Liu L,et al. The anatomic distribution and pulmonary embolism complications of hospital-acquired lower extremity deep venous thrombosis[J]. J Vasc Surg Venous Lymphat Disord,2021,9(6):1391-1398.e3. doi: 10.1016/j.jvsv.2021.03.004
    [14]
    Galanaud J P,Sevestre M A,Genty C,et al. OPTIMEV-SFMV investigators. Incidence and predictors of venous thromboembolism recurrence after a first isolated distal deep vein thrombosis[J]. J Thromb Haemost,2014,12(4):436-443. doi: 10.1111/jth.12512
    [15]
    Schellong S M. Low risk is not enough: the dilemma of calf vein thrombosis[J]. Lancet Haematol,2016,3(12):e548-e549. doi: 10.1016/S2352-3026(16)30164-8
    [16]
    牛文强,李鲁滨,车海杰,等. 小腿肌肉静脉血栓的诊疗进展[J]. 中国临床医生杂志,2022,50(4):411-413.
    [17]
    中华医学会骨科学分会创伤骨科学组. 创伤骨科患者深静脉血栓形成筛查与治疗的专家共识[J]. 中华创伤骨科杂志,2013,15(12):1013-1017.
    [18]
    Sivagangailakshmi V,Rajkumar D. Effects of cigarette smoking on coagulation profile among smokers[J]. IAIM,2017,4(8):116-20.
    [19]
    田雪婧,李南. 炎症在肺血栓栓塞症发生及发展中的作用[J]. 国际呼吸杂志,2022,42(3):222-226. doi: 10.3760/cma.j.cn131368-20211130-00882
    [20]
    鲁敏晔. 老年脑卒中后卧床患者下肢深静脉血栓发生的影响因素调查[J]. 中华全科医学,2016,14(10):1710-1712.
    [21]
    美国机动车医学促进会(AAAM), 重庆市急救医疗中心编译. 简明损伤定级标准2005[M]. 重庆: 重庆出版社, 2005: 1-35.
    [22]
    杨超,张旭,等. 创伤严重程度评分对多发创伤患者深静脉血栓形成的预测价值[J]. 实用医学杂志,2021,37(18):2371-2374.
    [23]
    傅一牧,荆尧,李冬冬,等. 多发伤患者急性下肢深静脉血栓形成的危险因素分析[J]. 上海交通大学学报(医学版),2019,39(3):278-281.
    [24]
    李树灏. 下肢闭合骨折24小时内和延迟入院后下肢深静脉血栓的发生规律[D]. 西安: 西安医学院, 2020.
    [25]
    Kujath P,Spannagel U,Habscheid W. Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb[J]. Haemostasis,1993,23(Suppl 1):20-26.
    [26]
    侯国进,周方,等. 下肢骨折患者围手术期静脉血栓栓塞症的影响因素及预防[J]. 中华创伤骨科杂志,2014,16(8):690-694.
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