Analysis of Molecular Characteristics of Mycobacterium Tuberculosis and Factors Associated with Transmission in Yunnan Province

Lianyong CHEN; Xing YANG; Haohao RU; Tao CHEN; Shuangqun YAN; Lin XU

doi:10.12259/j.issn.2095-610X.S20230821

Volume 44 Issue 8

Aug. 2023

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Lianyong CHEN, Xing YANG, Haohao RU, Tao CHEN, Shuangqun YAN, Lin XU. Analysis of Molecular Characteristics of Mycobacterium Tuberculosis and Factors Associated with Transmission in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(8): 1-7. doi: 10.12259/j.issn.2095-610X.S20230821

Citation:

Lianyong CHEN, Xing YANG, Haohao RU, Tao CHEN, Shuangqun YAN, Lin XU. Analysis of Molecular Characteristics of Mycobacterium Tuberculosis and Factors Associated with Transmission in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(8): 1-7. doi: 10.12259/j.issn.2095-610X.S20230821

Citation:

Lianyong CHEN, Xing YANG, Haohao RU, Tao CHEN, Shuangqun YAN, Lin XU. Analysis of Molecular Characteristics of Mycobacterium Tuberculosis and Factors Associated with Transmission in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(8): 1-7. doi: 10.12259/j.issn.2095-610X.S20230821

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Analysis of Molecular Characteristics of Mycobacterium Tuberculosis and Factors Associated with Transmission in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20230821

Institute for Tuberculosis Control and Prevention，Yunnan Center for Disease Control and Prevention，Kunming Yunnan 650022，China

Received Date: 2023-06-07
Available Online: 2023-09-05
Publish Date: 2023-08-30

Abstract

Abstract

Objective To understand the distribution characteristics, transmission, and related influencing factors of Mycobacterium tuberculosis genotypes in Yunnan Province, and to provide policy basis for tuberculosis control. Methods Mycobacterium tuberculosis strains isolated from 32 drug-resistant monitoring counties districts in Yunnan Province from 2016 to 2019 were collected, and Spoligotyping and 15 MIRU-VNTR loci were used for genetic typing of Mycobacterium tuberculosis. Results A total of 846 Mycobacterium tuberculosis strains were collected, of which 539 strains were Beijing genotype （63.71%）, 307 strains were non-Beijing genotype, including 16 genotypes such as T1 （20.69%, 175/846）, T3 （4.49%, 38/846）, T2 （2.36%, 20/846）, and 42 strains （4.96%） were newly discovered or undefined strains. The clustering rate of 846 Mycobacterium tuberculosis strains was 25.89%, of which the clustering rate of Beijing genotype was 29.68%, and the clustering rate of non-Beijing genotype was 19.22%. There was a significant difference between the two （χ² = 15.14, P < 0.001）. Beijing genotype and non-Beijing genotype Mycobacterium tuberculosis were not related to drug resistance. Logistic regression analysis showed that the clustering risk of Beijing genotype was 1.861 times that of non-Beijing genotype （P < 0.05, 95% CI 1.376-2.516）, and the risk of INH-sensitive strains was 1.869 times that of drug-resistant strains （P < 0.05, 95% CI 1.129-3.094）. Conclusion The Mycobacterium tuberculosis genotypes in Yunnan province are highly polymorphic, but the Beijing genotype is still the main epidemic strain. There is recent prevalence of tuberculosis in Yunnan Province, and Beijing genotype and INH sensitivity are influencing factors for recent transmission.
- Tuberculosis,
- Mycobacterium tuberculosis,
- Genotype,
- Molecular epidemiology,
- Recent prevalence

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