The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents

Liping LI; Hongchao ZHAO; Huiqiong ZHAO; Jun LI

doi:10.12259/j.issn.2095-610X.S20230903

Volume 44 Issue 9

Sep. 2023

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Liping LI, Hongchao ZHAO, Huiqiong ZHAO, Jun LI. The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents[J]. Journal of Kunming Medical University, 2023, 44(9): 80-85. doi: 10.12259/j.issn.2095-610X.S20230903

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Liping LI, Hongchao ZHAO, Huiqiong ZHAO, Jun LI. The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents[J]. Journal of Kunming Medical University, 2023, 44(9): 80-85. doi: 10.12259/j.issn.2095-610X.S20230903

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The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents

doi: 10.12259/j.issn.2095-610X.S20230903

1.
Dept. of Ophthalmology，Yuxi People’s Hospital，Yuxi Yunnan 653100
2.
Dept. of Ophthalmology，The Affiliated Hospital of Yunnan University，Kunming Yunnan 650021，China

Received Date: 2023-07-11
Available Online: 2023-09-23
Publish Date: 2023-09-30

Abstract

Abstract

Objective To investigate the effect of different concentrations of atropine on myopia prevention and control in adolescents. Methods A prospective double-blind randomized controlled trial was conducted. A total of 86 adolescent myopia patients admitted to the Department of Ophthalmology, Yuxi People’s Hospital from October 2021 to October 2022 were selected and divided into three groups by random number table method. Among them, 26 cases only wore the proper framework of single focal lens. Study group 1 （n = 30） and study group 2 （n = 30） were treated with 0.01% and 0.05% atropine eye drops while wearing fully corrected monocular frames, respectively. The axial length （AL）, uncorrected visual acuity （UCVA）, and refractive index of three groups before and after the treatment, and the clinical treatment effectiveness and adverse reaction rates of study 1 and study 2 groups were recorded respectively. Results Before the treatment, there were no statistically significant differences in ocular axial length, naked eye sight, diopter index comparison among the three groups（P > 0.05）; After the treatment, the axial length of study group 1 and study group 2 was shorter than that of the control group, the uncorrected visual acuity was higher than that of the control group, and the diopter was lower than that of the control group. There were statistically significant differences （P < 0.05）. The axial length of study group 1 and study group 2 was shorter than that of the control group, and the naked eye vision was higher than that of the control group. The diopter was lower than that of the control group, and there was a statistically significant difference （P < 0.05）; The treatment effectiveness rate of 96.67% （29/30） in study group 2 was higher than that of 73.33% （22/30） in study group 1, with a statistically significant difference （P < 0.05）; In terms of the incidence of adverse reactions, study group 1 was 13.33% （4/30）, and study group 2 was 6.67% （2/30）, with no statistically significant difference （P > 0.05）. Conclusion Compared with those only wearing the whole framework of single focal lens correction, the application of 0.01% and 0.05% atropine eye drops in juvenile myopia prevention and control of all have a certain therapeutic effect. Among them, 0.05% atropine application is more effective and it can effectively shorten the ocular axial length and improve the naked eye sight so as to reduce the diopter and incidence of adverse reactions and effectively improve the clinical treatment.
- Juvenile myopia,
- Atropine,
- Axial length,
- Uncorrected visual acuity,
- Diopter,
- Response rate of treatment

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References(18)

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