Liping LI, Hongchao ZHAO, Huiqiong ZHAO, Jun LI. The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents[J]. Journal of Kunming Medical University, 2023, 44(9): 80-85. doi: 10.12259/j.issn.2095-610X.S20230903
Citation: Liping LI, Hongchao ZHAO, Huiqiong ZHAO, Jun LI. The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents[J]. Journal of Kunming Medical University, 2023, 44(9): 80-85. doi: 10.12259/j.issn.2095-610X.S20230903

The Effect of Different Concentrations of Atropine on Myopia Prevention and Control in Adolescents

doi: 10.12259/j.issn.2095-610X.S20230903
  • Received Date: 2023-07-11
    Available Online: 2023-09-23
  • Publish Date: 2023-09-30
  •   Objective  To investigate the effect of different concentrations of atropine on myopia prevention and control in adolescents.  Methods  A prospective double-blind randomized controlled trial was conducted. A total of 86 adolescent myopia patients admitted to the Department of Ophthalmology, Yuxi People’s Hospital from October 2021 to October 2022 were selected and divided into three groups by random number table method. Among them, 26 cases only wore the proper framework of single focal lens. Study group 1 (n = 30) and study group 2 (n = 30) were treated with 0.01% and 0.05% atropine eye drops while wearing fully corrected monocular frames, respectively. The axial length (AL), uncorrected visual acuity (UCVA), and refractive index of three groups before and after the treatment, and the clinical treatment effectiveness and adverse reaction rates of study 1 and study 2 groups were recorded respectively.  Results  Before the treatment, there were no statistically significant differences in ocular axial length, naked eye sight, diopter index comparison among the three groups(P > 0.05); After the treatment, the axial length of study group 1 and study group 2 was shorter than that of the control group, the uncorrected visual acuity was higher than that of the control group, and the diopter was lower than that of the control group. There were statistically significant differences (P < 0.05). The axial length of study group 1 and study group 2 was shorter than that of the control group, and the naked eye vision was higher than that of the control group. The diopter was lower than that of the control group, and there was a statistically significant difference (P < 0.05); The treatment effectiveness rate of 96.67% (29/30) in study group 2 was higher than that of 73.33% (22/30) in study group 1, with a statistically significant difference (P < 0.05); In terms of the incidence of adverse reactions, study group 1 was 13.33% (4/30), and study group 2 was 6.67% (2/30), with no statistically significant difference (P > 0.05).  Conclusion  Compared with those only wearing the whole framework of single focal lens correction, the application of 0.01% and 0.05% atropine eye drops in juvenile myopia prevention and control of all have a certain therapeutic effect. Among them, 0.05% atropine application is more effective and it can effectively shorten the ocular axial length and improve the naked eye sight so as to reduce the diopter and incidence of adverse reactions and effectively improve the clinical treatment.
  • [1]
    许晓丽,高路,杨晨皓. 上海市闵行区青少年儿童视力发育及屈光状态流行病学调查[J]. 中国儿童保健杂志,2021,29(9):1000-1003.
    [2]
    Diaz-Llopis M,Pinazo-Durán M D. Superdiluted atropine at 0.01% reduces progression in children and adolescents. A 5 year study of safety and effectiveness[J]. Archivos de la Sociedad Españ ola de Oftalmología (English Edition),2018,93(4):182-185.
    [3]
    Wang N L,Li S M,Wei S F. The key points and difficulties in prevention of myopia in Chinese children and adolescents[J]. [Zhong Hua Yan Ke Za Zhi] Chinese Journal of Ophthalmology,2021,57(4):241-244.
    [4]
    袁梅娟,林泉. 角膜塑形镜控制近视性屈光参差的研究进展[J]. 国际眼科杂志,2022,22(8):1318-1322.
    [5]
    李丽萍,赵洪超,陈前,等. 0.01%阿托品滴眼液联合视功能训练在轻度近视患者中的疗效及对视力水平的影响[J]. 昆明医科大学学报,2021,42(6):67-71.
    [6]
    Zhao C,Cai C,Ding Q,et al. Efficacy and safety of atropine to control myopia progression: A systematic review and meta-analysis[J]. BMC Ophthalmology,2020,20(1):1-8. doi: 10.1186/s12886-019-1277-9
    [7]
    李松玉,杨迎新,杨潮,等. 不同浓度阿托品滴眼液控制儿童青少年近视进展的Meta分析[J]. 国际眼科杂志,2023,23(1):96-102.
    [8]
    吴雨璇,林卓玲,吴晓航,等. 光学眼科生物测量仪StarEyes900与IOLMaster500对眼球生物学测量的一致性评价[J]. 眼科学报,2022,37(2):125-130.
    [9]
    Ye L,Xu H,Shi Y,et al. Efficacy and safety of consecutive use of 1% and 0.01% atropine for myopia control in chinese children: The atropine for children and adolescent myopia progression study[J]. Ophthalmology and Therapy,2022,11(6):2197-2210. doi: 10.1007/s40123-022-00572-1
    [10]
    李媛媛,张晓峰. 青少年儿童近视形成的影响因素和治疗进展[J]. 国际眼科杂志,2018,18(12):2179-2182.
    [11]
    赵文辰,何鲜桂,邓俊杰. 关于儿童和青少年高度近视干预措施的争议[J]. 中华实验眼科杂志,2022,40(6):588-593.
    [12]
    白桂桃,胡丽婷,李慧,等. 角膜塑形镜控制青少年近视进展有效性和安全性观察[J]. 青岛大学学报(医学版),2022,58(2):221-224.
    [13]
    Zhu Q,Yin J,Li X,et al. Effects of long-term wear and discontinuation of orthokeratology lenses on the eyeball parameters in children with Myopia[J]. International Journal of Medical Sciences,2023,20(1):50-56. doi: 10.7150/ijms.79496
    [14]
    张育,舒红莉,程妮. 低浓度阿托品滴眼液联合多焦点渐变镜治疗青少年中度近视的临床效果[J]. 临床医学研究与实践,2022,7(35):29-32.
    [15]
    张立新,刘辉焜,朱国平,等. 不同低浓度阿托品制剂对青少年近视防控效果及安全性探析[J]. 国际医药卫生导报,2019,25(24):4002-4006.
    [16]
    戴荣源. 无近视儿童夜间使用0.05%阿托品滴眼液可显著降低近视发生率[J]. 中国临床药理学杂志,2023,39(7):965.
    [17]
    Yam J C,Zhang X J,Zhang Y,et al. Three-year clinical trial of low-concentration atropine for myopia progression (LAMP) study: Continued versus washout: phase 3 report[J]. Ophthalmology,2022,129(3):308-321. doi: 10.1016/j.ophtha.2021.10.002
    [18]
    Zhang M,Qiu W,An M,et al. Analysis of the reports of low-concentration atropine in controlling myopia in children[J]. Journal Franç ais d'Ophtalmologie,2023,46(3):239-248.
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    Periodical cited type(26)

    1. 张丽丽,冯煦苑. 2016—2022年河南省驻马店市食源性疾病暴发事件监测结果. 现代疾病预防控制. 2024(03): 231-236 .
    2. 杨小玲,黄东升,钟玉娟,赵金燕,李婧,苏玮玮. 2018—2022年保山市食源性疾病暴发事件流行病学特征分析. 食品安全导刊. 2024(09): 1-5 .
    3. 刘光杰,王银梦,番凤仙,陈正统,郭超. 腾冲市2012—2023年蘑菇中毒事件流行病学特征分析. 食品安全导刊. 2024(20): 60-64 .
    4. 程永兵,薛波,史伟,王甜. 2018-2022年陕西省食源性疾病暴发事件流行病学特征分析. 预防医学论坛. 2024(10): 779-782 .
    5. 郜明明,陆金凤,孙佳皓. 2011—2021年盐城市食源性疾病暴发事件监测结果分析. 职业与健康. 2023(09): 1206-1209 .
    6. 邢超,王琦梅,任蒋磊,陈吉铭,何琴芬,蒋卓婧. 2012—2022年绍兴市食源性疾病暴发事件流行特征分析. 预防医学. 2023(06): 506-508+513 .
    7. 袁蒲,韩涵,叶冰,张书芳,付鹏钰,李杉,杨丽. 2019年河南省食源性疾病事件监测分析. 预防医学情报杂志. 2022(02): 152-155+160 .
    8. 刘仁泉,曹建国,杨平华,杨彦玲. 2010—2019年云南省昭通市食源性疾病暴发情况分析. 公共卫生与预防医学. 2022(02): 69-72 .
    9. 刘春梅,孙玲,白俊,毛琦,朱静,何慧芝,程锦芳,牛晓文,杨晓敏,杨洪元,罗会平,何国敏. 云南省勐腊县2017—2021年食源性疾病暴发事件的流行特征分析. 上海预防医学. 2022(10): 1002-1006 .
    10. 万蓉,赵江,万青青,李娟娟,彭敏,刘志涛. 2011—2019年云南省食物中毒流行特征分析及预防措施探讨. 食品安全质量检测学报. 2021(04): 1620-1624 .
    11. 刘志涛,赵江,李娟娟,闵向东,阮元,苏玮玮,朱晓,陈留萍,杨彦玲,张强,董海燕. 云南省2015—2020年野生蕈中毒流行特征及趋势预测. 食品安全质量检测学报. 2021(17): 7074-7079 .
    12. 袁蒲,叶冰,付鹏钰,周昇昇,李杉,杨丽,韩涵,钞凤,张书芳. 河南省2019年食源性疾病暴发事件流行病学特征分析. 医学动物防制. 2021(12): 1207-1209+1214 .
    13. 袁蒲,张书芳,付鹏钰,叶冰,韩涵,李杉,杨丽,周昇昇,钞凤. 2016—2020年河南省餐饮单位食源性疾病暴发事件流行病学特征分析. 现代预防医学. 2021(23): 4240-4244 .
    14. 郑艳敏,滕臣刚,张梦寒,田礼钦. 2014-2018年苏州市食源性疾病暴发事件流行特征分析. 现代预防医学. 2020(02): 215-218+232 .
    15. 黄信有,张芝平,刘振江,吴春蕾,程莹婷,陈华,杨铭建. 1998—2017年南平市食源性疾病事件流行病学特征分析. 中国食品卫生杂志. 2020(02): 184-189 .
    16. 刘颜,何玲玲,罗赟,孙雪梅,童菲. 2010—2018年绵阳市食源性疾病事件流行病学分析. 实用预防医学. 2020(05): 538-542 .
    17. 李英菊. 2012—2018年梧州市食源性疾病暴发监测分析. 职业与健康. 2020(13): 1767-1770 .
    18. 张晶晶,朱静静,金富红,杨海鑫,黄艾祥. 云南部分地区熟肉制品中食源性致病菌的污染情况及耐药性分析. 食品安全质量检测学报. 2020(18): 6552-6556 .
    19. 刘志涛,张强,李娟娟,阮元,杨彦玲,苏玮玮,彭敏,万青青,赵江. 2010~2019年云南省野生蜂蜜中毒事件分析. 食品安全质量检测学报. 2020(23): 9063-9067 .
    20. 田礼钦,王小龙,郑艳敏. 2001~2018年苏州市学校食源性疾病暴发事件分析. 食品安全质量检测学报. 2019(06): 1690-1694 .
    21. 刘颜,何玲玲,罗赟,吴晓红. 2015—2018年绵阳市食源性疾病事件监测结果. 职业与健康. 2019(17): 2341-2345 .
    22. 万蓉,刘志涛,万青青,李娟娟,彭敏,赵江. 2011-2017年云南省野生菌中毒情况分析. 卫生软科学. 2019(10): 84-86+97 .
    23. 刘桂丹,范正轩,黄伟,杨万里. 2017—2018年自贡市食源性疾病暴发事件监测分析. 职业与健康. 2019(23): 3205-3208 .
    24. 陆子春,蒋一,曾宏. 2013—2018年佳木斯市食源性疾病暴发事件特征分析. 中国初级卫生保健. 2019(11): 72-75 .
    25. 赵江,汤钦岚,闵向东,张强,万蓉,刘志涛. 2010-2018年云南省毒蕈中毒事件分析. 首都公共卫生. 2019(06): 280-282 .
    26. 李荣华. 2014~2018年济宁市食源性疾病事件流行病学特征分析. 预防医学论坛. 2019(11): 872-874 .

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