Changes and Meaning of Serum IL-1β，IL-2，IL-4，IL-5， IL-6 in Patients with Pregnancy Syndrome in Hypertensive Diseases

Wenbiao SHI; Cailiang MA; Yalin ZHAO; Feng WANG; Julin WANG; Mihui ZHANG

doi:10.12259/j.issn.2095-610X.S20230909

Volume 44 Issue 9

Sep. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(9): 100-103

Wenbiao SHI, Cailiang MA, Yalin ZHAO, Feng WANG, Julin WANG, Mihui ZHANG. Changes and Meaning of Serum IL-1β，IL-2，IL-4，IL-5， IL-6 in Patients with Pregnancy Syndrome in Hypertensive Diseases[J]. Journal of Kunming Medical University, 2023, 44(9): 100-103. doi: 10.12259/j.issn.2095-610X.S20230909

Citation:

Wenbiao SHI, Cailiang MA, Yalin ZHAO, Feng WANG, Julin WANG, Mihui ZHANG. Changes and Meaning of Serum IL-1β，IL-2，IL-4，IL-5， IL-6 in Patients with Pregnancy Syndrome in Hypertensive Diseases[J]. Journal of Kunming Medical University, 2023, 44(9): 100-103. doi: 10.12259/j.issn.2095-610X.S20230909

Citation:

Wenbiao SHI, Cailiang MA, Yalin ZHAO, Feng WANG, Julin WANG, Mihui ZHANG. Changes and Meaning of Serum IL-1β，IL-2，IL-4，IL-5， IL-6 in Patients with Pregnancy Syndrome in Hypertensive Diseases[J]. Journal of Kunming Medical University, 2023, 44(9): 100-103. doi: 10.12259/j.issn.2095-610X.S20230909

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Changes and Meaning of Serum IL-1β，IL-2，IL-4，IL-5， IL-6 in Patients with Pregnancy Syndrome in Hypertensive Diseases

doi: 10.12259/j.issn.2095-610X.S20230909

1.
Section 1 of The Childbirth Department
2.
Section 3 of The Gynecology Department
3.
The Clinical Laboratory of Qujing Maternal and Child Health Hospital， Qujing Yunnan 655000，China

Received Date: 2023-07-15
Publish Date: 2023-09-25

Abstract

Abstract

Objective To observe the expression of peripheral blood IL-1β, IL-2, IL-4, IL-5, IL-6 levels in patients with gestational hypertension and explore the importance of peripheral blood cytokines in HDCP and their relations to the severity of the disease. Methods Multiple microsphere flow immunofluorescence assay was used to measure the levels of IL-1β, IL-2, IL-4, IL-5, IL-6 （27 patients with gestational hypertension, 18 patients with preeclampsia, 15 patients with severe preeclampsia）and 20 normal pregnant women were measured in 60 HDCP patients . Results The serum levels of IL-1β, IL-2, IL-4, IL-5 and IL-6 in HDCP group were（12.53±1.32） pg/mL, （10.69±1.40） pg/mL, （1.02± 6.77） pg/mL, （4.41±1.29） pg/mL, （23.32±4.58） pg/mL, respectively. Normal pregnant women were（10.25±1.42） pg/mL, （4.41±1.32） pg/mL, （6.86±4.62） pg/mL, （5.31±1.31） pg/mL, and（6.82±1.02） pg/mL, respectively, The difference in IL-2、IL-4、IL-6 was statistically significant（ P < 0.05） , while the difference in IL-1β and IL-5 was not statistically significant （ P > 0.05） . The levels of IL-2 and IL-6 were significantly different in the classificationof HDCP（ P < 0.05）. However, there was no significant difference in serum levels of IL-4（ P > 0.05） . Conclusion Patients with gestational hypertension have significantly increased levels of IL-2 and IL-6 in their peripheral blood, which increase with the severity of the condition. IL-4 levels are significantly reduced but not related to the severity of the disease. Abnormal expression levels of IL-2, IL-6, and IL-4 in peripheral blood may induce the endothelial cell damage, abnormal immune activation, and promote the occurrence and development of pregnancy-induced hypertension.
- Hypertensive disorder complicating pregnancy,
- Il-1β,
- IL-2,
- IL-4,
- IL-5,
- IL-6,
- Flow immunofluorescence assay

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References(10)

References

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