Network Meta-Analysis of Three Different Interventional Methods for the Treatment of Tracheobronchial Tuberculosis

Xiaodie YAO; Hao FAN; Lingjun SHEN; Shengan ZHENG; Menghan JIANG; Lei SHEN; Jie CHEN; Xing LIU

doi:10.12259/j.issn.2095-610X.S20230912

Volume 44 Issue 9

Sep. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(9): 110-120

Xiaodie YAO, Hao FAN, Lingjun SHEN, Shengan ZHENG, Menghan JIANG, Lei SHEN, Jie CHEN, Xing LIU. Network Meta-Analysis of Three Different Interventional Methods for the Treatment of Tracheobronchial Tuberculosis[J]. Journal of Kunming Medical University, 2023, 44(9): 110-120. doi: 10.12259/j.issn.2095-610X.S20230912

Citation:

Xiaodie YAO, Hao FAN, Lingjun SHEN, Shengan ZHENG, Menghan JIANG, Lei SHEN, Jie CHEN, Xing LIU. Network Meta-Analysis of Three Different Interventional Methods for the Treatment of Tracheobronchial Tuberculosis[J]. Journal of Kunming Medical University, 2023, 44(9): 110-120. doi: 10.12259/j.issn.2095-610X.S20230912

Citation:

Xiaodie YAO, Hao FAN, Lingjun SHEN, Shengan ZHENG, Menghan JIANG, Lei SHEN, Jie CHEN, Xing LIU. Network Meta-Analysis of Three Different Interventional Methods for the Treatment of Tracheobronchial Tuberculosis[J]. Journal of Kunming Medical University, 2023, 44(9): 110-120. doi: 10.12259/j.issn.2095-610X.S20230912

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Network Meta-Analysis of Three Different Interventional Methods for the Treatment of Tracheobronchial Tuberculosis

doi: 10.12259/j.issn.2095-610X.S20230912

1.
School of Pharmaceutical Sciences，Dali University，Dali Yunnan 671000
2.
The Third People’s Hospital of Kunming/Yunnan Provincial Infectious Disease Clinical Medical Center，Kunming Yunnan 650041，China

Received Date: 2023-06-16
Available Online: 2023-09-23
Publish Date: 2023-09-30

Abstract

Abstract

Objective To systematically evaluate the efficacy and safety of different bronchoscopic intervention methods combined with the conventional anti-tuberculosis regimen in the treatment of tracheobronchial tuberculosis （TBTB）, and to provide the evidence-based reference for clinical practice. Methods Computer search PubMed, Web of Science, EMBase, CNKI, Wanfang Database, VIP database, randomized controlled trials （RCTS） of different bronchoscopic interventions （local administration, cryotherapy, and atomization） combined with conventional anti-tuberculosis therapy were collected. After the data extraction and quality evaluation, network meta-analysis was performed using Stata 16.0 software. Results A total of 38 RCTS were included, involving a total of 3114 patients and three interventions （conventional + local administration, conventional+ cryotherapy, conventional + local administration + atomization）. Compared with the conventional treatment, conventional+ cryotherapy, conventional + local administration, conventional + local administration + atomization could significantly improve the total clinical response rate （P < 0.05）. The results of mesh Meta ranking were conventional + local administration + atomization > conventional + local administration > conventional + cryotherapy > conventional. Compared with the conventional treatment, conventional + cryotherapy, conventional + local administration, conventional + local administration + atomization could significantly improve the effective rate of fiberoptic bronchoscopy （P < 0.05）. The results of mesh Meta ranking were conventional + local administration > conventional + local administration + atomization > conventional + cryotherapy > conventional. Compared with the conventional treatment, conventional + local administration, conventional + local administration + atomization could significantly improve the sputum negative conversion rate at the end of 8 weeks after the treatment （P < 0.05）. Compared with conventional + cryotherapy, conventional + local administration could significantly improve the sputum negative conversion rate at the end of 8 weeks after treatment （P < 0.05）. The results of mesh Meta ranking were conventional + local administration > conventional + local administration + atomization > conventional + cryotherapy > conventional. Compared with the conventional treatment, conventional + local administration could significantly improve the sputum negative conversion rate at the end of 24 weeks after treatment （P < 0.05）. The results of mesh Meta ranking were conventional + local administration > conventional + local administration + atomization > conventional + cryotherapy > conventional. There was no statistically significant difference in the incidence of adverse reactions among all groups （P > 0.05）. Conclusion The conventional + local administration + atomization scheme has the most significant improvement effect, while the conventional + local administration scheme has the best effect in improving the effective rate under bronchoscopy. In TBTB patients, the conventional + local administration + atomization regimen can accelerate the sputum to negative in the early stage, but the conventional + local administration regimen can accelerate the conversion of sputum to negative in the long-term treatment. Bronchoscopic intervention on the basis of conventional anti-tuberculosis therapy does not increase adverse reactions and has the good safety. However, this study needs to be further verified by including more high-quality, double-blind RCTS.
- Network meta-analysis,
- Bronchoscopic interventional therapy,
- Tracheobronchial tuberculosis,
- Curative effect,
- Systematic evaluation

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