Mechanism and Progress of MSC Derived Extracellular Vesicles in the Treatment of Ischemic Stroke

Shijie CAO; Hongwei AN

doi:10.12259/j.issn.2095-610X.S20230913

Volume 44 Issue 9

Sep. 2023

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Shijie CAO, Hongwei AN. Mechanism and Progress of MSC Derived Extracellular Vesicles in the Treatment of Ischemic Stroke[J]. Journal of Kunming Medical University, 2023, 44(9): 155-160. doi: 10.12259/j.issn.2095-610X.S20230913

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Shijie CAO, Hongwei AN. Mechanism and Progress of MSC Derived Extracellular Vesicles in the Treatment of Ischemic Stroke[J]. Journal of Kunming Medical University, 2023, 44(9): 155-160. doi: 10.12259/j.issn.2095-610X.S20230913

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Mechanism and Progress of MSC Derived Extracellular Vesicles in the Treatment of Ischemic Stroke

doi: 10.12259/j.issn.2095-610X.S20230913

Shijie CAO¹,
Hongwei AN^{2
,
,}

1.
Guangxi University of Chinese Medicine，Nanning Guangxi 530001
2.
Liuzhou Traditional Chinese Medicine Hospital，Liuzhou Guangxi 545001，China

Received Date: 2023-05-09
Available Online: 2023-09-23
Publish Date: 2023-09-30

Abstract

Abstract

Cerebral ischemic stoke is a disease in which oxidative stress, activation of inflammatory storms, interference, induction of apoptosis, and blood reperfusion aggravate the tissue and cell damage due to ischemia and hypoxia. Mesenchymal stem cells（MSCs） induce the angiogenesis and can be used to treat the ischemia-reperfusion injury, anti-apoptosis and anti-inflammatory. Preclinical studies have confirmed that targeted delivery of mesenchymal-derived exosomes to recipient cells exerts the effects of inducing angiogenesis, anti-apoptosis, and anti-inflammatory, while avoiding the shortcomings of mesenchymal stem cell therapy. The purpose of this study is to summarize the mechanism of exosomes derived from mesenchymal stem cells in the treatment of stroke so as to provide new opportunities for treating ischemic cerebrovascular disease clinically.
- Mesenchymal stem cells,
- Exosomes,
- Stroke

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References(31)

References

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