The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients

Quanchang ZHANG; Qiaolian WU; Yu LIU; Xin ZHAO

doi:10.12259/j.issn.2095-610X.S20230919

Volume 44 Issue 9

Sep. 2023

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Quanchang ZHANG, Qiaolian WU, Yu LIU, Xin ZHAO. The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients[J]. Journal of Kunming Medical University, 2023, 44(9): 104-109. doi: 10.12259/j.issn.2095-610X.S20230919

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The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients

doi: 10.12259/j.issn.2095-610X.S20230919

Dept. of General Surgery，The 2nd People’s Hospital of Kunming， Kunming Yunnan 650000，China

Received Date: 2023-04-01
Available Online: 2023-09-21
Publish Date: 2023-09-30

Abstract

Abstract

Objective To investigate the effects of different methods of complete mesocolectomy （CME） on the platelet activation, complication rate and tumor recurrence in patients with colon cancer. Methods 80 patients with colon cancer in The 2nd People's Hospital of Kunming from January 2020 to January 2022 were selected and divided into 2 groups according to the treatment plan, with 40 cases in each group. The control group underwent open CME, and the observation group underwent laparoscopic CME to compare the perioperative situation, number of lymph node dissection, incidence of postoperative complications, as well as serum inflammatory [interleukin-6 （IL-6）, C-reactive protein （CRP）] and platelet activation indicators [platelet neutrophil aggregates （PNA）, platelet lymphocytic aggregation （PlyA）, platelet leukocyte aggregation （PMA）, platelet leukocyte aggregates （PLA）] before and after surgery and the tumor recurrence rate between the two groups. Results The intraoperative blood loss and postoperative drainage volume in the observation group were less than those in the control group, and the anal defecation time, anal exhaust time and hospitalization days were shorter than those in the control group （P < 0.05）. The number of stage III, positive and left and right hemicolic lymph nodes dissection in the observation group was higher than that in the control group, and the incidence of postoperative complications was lower than that in the control group （P < 0.05）. Serum IL-6 and CRP in the observation group were lower than those in the control group 1 day after the operation （P < 0.05）. PLA, PlyA, PMA and PNA in the observation group were lower than those in the control group 1 day after the operation （P < 0.05）. The one-year recurrence rate of the observation group was lower than that of the control group, and the survival time without recurrence was longer than that of the control group （P < 0.05）. Conclusion The operative time of laparoscopic CME for colon cancer is similar to that of open CME, but it can reduce the intraoperative bleeding, reduce the inflammatory response, improve the platelet activation, promote the disease recovery, improve the lymph node clearance, reduce the recurrence risk, prolong survival, and reduce complications.
- Colon cancer,
- Complete mesocolectomy,
- Open surgery,
- Laparoscopy,
- Lymph node dissection,
- Platelet activation,
- Recrudescence

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