The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients

Quanchang ZHANG; Qiaolian WU; Yu LIU; Xin ZHAO

doi:10.12259/j.issn.2095-610X.S20230919

Volume 44 Issue 9

Sep. 2023

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Quanchang ZHANG, Qiaolian WU, Yu LIU, Xin ZHAO. The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients[J]. Journal of Kunming Medical University, 2023, 44(9): 104-109. doi: 10.12259/j.issn.2095-610X.S20230919

Citation:

Quanchang ZHANG, Qiaolian WU, Yu LIU, Xin ZHAO. The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients[J]. Journal of Kunming Medical University, 2023, 44(9): 104-109. doi: 10.12259/j.issn.2095-610X.S20230919

Citation:

Quanchang ZHANG, Qiaolian WU, Yu LIU, Xin ZHAO. The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients[J]. Journal of Kunming Medical University, 2023, 44(9): 104-109. doi: 10.12259/j.issn.2095-610X.S20230919

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The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients

doi: 10.12259/j.issn.2095-610X.S20230919

Dept. of General Surgery，The 2nd People’s Hospital of Kunming， Kunming Yunnan 650000，China

Received Date: 2023-04-01
Available Online: 2023-09-21
Publish Date: 2023-09-30

Abstract

Abstract

Objective To investigate the effects of different methods of complete mesocolectomy （CME） on the platelet activation, complication rate and tumor recurrence in patients with colon cancer. Methods 80 patients with colon cancer in The 2nd People's Hospital of Kunming from January 2020 to January 2022 were selected and divided into 2 groups according to the treatment plan, with 40 cases in each group. The control group underwent open CME, and the observation group underwent laparoscopic CME to compare the perioperative situation, number of lymph node dissection, incidence of postoperative complications, as well as serum inflammatory [interleukin-6 （IL-6）, C-reactive protein （CRP）] and platelet activation indicators [platelet neutrophil aggregates （PNA）, platelet lymphocytic aggregation （PlyA）, platelet leukocyte aggregation （PMA）, platelet leukocyte aggregates （PLA）] before and after surgery and the tumor recurrence rate between the two groups. Results The intraoperative blood loss and postoperative drainage volume in the observation group were less than those in the control group, and the anal defecation time, anal exhaust time and hospitalization days were shorter than those in the control group （P < 0.05）. The number of stage III, positive and left and right hemicolic lymph nodes dissection in the observation group was higher than that in the control group, and the incidence of postoperative complications was lower than that in the control group （P < 0.05）. Serum IL-6 and CRP in the observation group were lower than those in the control group 1 day after the operation （P < 0.05）. PLA, PlyA, PMA and PNA in the observation group were lower than those in the control group 1 day after the operation （P < 0.05）. The one-year recurrence rate of the observation group was lower than that of the control group, and the survival time without recurrence was longer than that of the control group （P < 0.05）. Conclusion The operative time of laparoscopic CME for colon cancer is similar to that of open CME, but it can reduce the intraoperative bleeding, reduce the inflammatory response, improve the platelet activation, promote the disease recovery, improve the lymph node clearance, reduce the recurrence risk, prolong survival, and reduce complications.
- Colon cancer,
- Complete mesocolectomy,
- Open surgery,
- Laparoscopy,
- Lymph node dissection,
- Platelet activation,
- Recrudescence

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References(20)

References

[1]	Fabregas J C,Ramnaraign B,George T J. Clinical updates for colon cancer care in 2022[J]. Clin Colorectal Cancer,2022,21(3):198-203. doi: 10.1016/j.clcc.2022.05.006
[2]	Argilés G,Tabernero J,Labianca R,et al. Localised colon cancer: ESMO clinical practice guidelines for diagnosis,treatment and follow-up[J]. Ann Oncol,2020,31(10):1291-1305. doi: 10.1016/j.annonc.2020.06.022
[3]	Tejedor P,Francis N,Jayne D,et al. Consensus statements on complete mesocolic excision for right-sided colon cancer-technical steps and training implications[J]. Surg Endosc,2022,36(8):5595-5601. doi: 10.1007/s00464-021-08395-0
[4]	Degiuli M,Solej M,Resendiz Aguilar H A,et al. Complete mesocolic excision in comparison with conventional surgery for right colon cancer: A nationwide multicenter study of the Italian society of surgical oncology colorectal cancer network (CoME-in trial). Study protocol for a randomized controlled trial[J]. Jpn J Clin Oncol,2022,52(10):1232-1241.
[5]	张超超,付大磊,崔金凤. 3D腹腔镜下全结肠系膜切除术治疗右半结肠癌的效果观察[J]. 中国实用医刊,2020,47(24):70-73. doi: 10.3760/cma.j.cn115689-20200909-04391
[6]	Di Buono G,Buscemi S,Cocorullo G,et al. Feasibility and safety of laparoscopic complete mesocolic excision (CME) for right-sided colon cancer: Short-term outcomes. A randomized clinical study[J]. Ann Surg,2021,274(1):57-62. doi: 10.1097/SLA.0000000000004557
[7]	Leal-Noval S R,Casado M,Palomares C,et al. Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme[J]. Platelets,2023,34(1):2216802. doi: 10.1080/09537104.2023.2216802
[8]	Preckel B,Staender S,Arnal D,et al. Ten years of the helsinki declaration on patient safety in anaesthesiology: An expert opinion on peri-operative safety aspects[J]. Eur J Anaesthesiol,2020,37(7):521-610. doi: 10.1097/EJA.0000000000001244
[9]	国家卫生计生委医政医管局,中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2017年版)[J]. 中华胃肠外科杂志,2018,21(1):92-106.
[10]	Weiser M R. AJCC 8th Edition: Colorectal cancer[J]. Ann Surg Oncol,2018,25(6):1454-1455.
[11]	Benson A B,Venook A P,Al-Hawary M M,et al. Colon cancer,version 2.2021,NCCN Clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw,2021,19(3):329-359. doi: 10.6004/jnccn.2021.0012
[12]	Sica G S,Vinci D,Siragusa L,et al. Definition and reporting of lymphadenectomy and complete mesocolic excision for radical right colectomy: A systematic review[J]. Surg Endosc,2023,37(2):846-861. doi: 10.1007/s00464-022-09548-5
[13]	高王军,张光亚,王治伟. 腹腔镜全结肠系膜切除术治疗结肠癌的疗效观察[J]. 中国肿瘤临床与康复,2021,28(7):806-809.
[14]	Magistro C,Bertoglio C L,Giani A,et al. Laparoscopic complete mesocolic excision versus conventional resection for right-sided colon cancer: A propensity score matching analysis of short-term outcomes[J]. Surg Endosc,2022,36(5):3049-3058. doi: 10.1007/s00464-021-08601-z
[15]	陆峰,王刚,周井荣,等. 腹腔镜与开腹全结肠系膜切除手术治疗右半结肠癌的疗效比较[J]. 中国基层医药,2019,26(22):2716-2720.
[16]	崔艳成,周宇石,申占龙,等. 癌结节对根治性手术后Ⅲ期结肠癌患者预后的影响[J]. 中华普通外科杂志,2022,37(4):260-264.
[17]	Milone M,Desiderio A,Velotti N,et al. Surgical stress and metabolic response after totally laparoscopic right colectomy[J]. Sci Rep,2021,11(1):9652. doi: 10.1038/s41598-021-89183-7
[18]	翟金海,张佳怡,徐速. 血小板活化对肠微血管内皮细胞血管生成影响的实验研究[J]. 实用医学杂志,2021,37(5):579-584.
[19]	Nielsen V G,Goff T,Hunsaker B D,et al. The gilded clot: Review of metal-modulated platelet activation,coagulation,and fibrinolysis[J]. Int J Mol Sci,2023,24(4):3302. doi: 10.3390/ijms24043302
[20]	Ren J,He J,Zhang H,et al. Platelet TLR4-ERK5 axis facilitates NET-mediated capturing of circulating tumor cells and distant metastasis after surgical stress[J]. Cancer Res,2021,81(9):2373-2385. doi: 10.1158/0008-5472.CAN-20-3222

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