The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion

Xiaopei LV; Shuai YUAN

doi:10.12259/j.issn.2095-610X.S20230922

Volume 44 Issue 9

Sep. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(9): 143-147

Xiaopei LV, Shuai YUAN. The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion[J]. Journal of Kunming Medical University, 2023, 44(9): 143-147. doi: 10.12259/j.issn.2095-610X.S20230922

Citation:

Xiaopei LV, Shuai YUAN. The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion[J]. Journal of Kunming Medical University, 2023, 44(9): 143-147. doi: 10.12259/j.issn.2095-610X.S20230922

Citation:

Xiaopei LV, Shuai YUAN. The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion[J]. Journal of Kunming Medical University, 2023, 44(9): 143-147. doi: 10.12259/j.issn.2095-610X.S20230922

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The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion

doi: 10.12259/j.issn.2095-610X.S20230922

Xiaopei LV¹,
Shuai YUAN²

1.
Dept. of Neurology，Shijiazhuang People’s Hospital，Shijiazhuang Hebei 050000
2.
Dept. of Radiology，Hebei Chest Hospital，Shijiazhuang Hebei 050041，China

Received Date: 2023-03-01
Available Online: 2023-09-14
Publish Date: 2023-09-30

Abstract

Abstract

Objective To investigate the effect of butylphthalide on cognitive dysfunction after the stroke caused by cerebral small vessel disease and its effect on cerebral blood perfusion. Methods 84 patients with the cognitive impairment after the stroke caused by small vessel disease were retrospectively selected from the Neurology Department of Shijiazhuang People’s Hospital from March 2019 to March 2021. According to the different treatment methods, they were divided into the control group （basic treatment） and the study group （basic treatment+butylphthalide treatment）, with 42 patients in each group. Cognitive function, daily living ability, neurological function deficits, and changes in cerebral blood flow perfusion were observed. Results After 3 months of treatment, MMSE and Barthel index scores increased and NIHSS scores decreased in the two groups （P < 0.05）. After the treatment, MMSE and Barthel index scores in the study group were higher than those in the control group （P < 0.05）. The mean passage time of patients in the two groups decreased, and the CEREBRAL blood flow and blood flow velocity increased. In comparison with the results between the two groups, the mean passage time of patients in the study group was lower than that of the control group after the treatment, while the cerebral blood flow and blood flow velocity were significantly higher than that of the control group （P < 0.05）. Conclusion Butylphthalide can improve the cerebral blood flow perfusion and promote the recovery of patients’ cognitive function and daily living ability in the treatment of cognitive dysfunction after the stroke caused by cerebral small vascular disease.
- Butylphthalide,
- Cerebrovascular disease,
- Stroke,
- Cognitive dysfunction,
- Cerebral perfusion

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References(20)

References

[1]	樊建华. 脑小血管病所致急性腔隙性脑卒中静脉溶栓的疗效及预后分析[J]. 中国血液流变学杂志,2017,27(4):392-395,407.
[2]	朱慧,付文君,陈绪丰,等. 脑小血管病对大动脉粥样硬化型脑梗死患者神经功能及脑卒中复发的影响[J]. 中华神经医学杂志,2018,17(4):419-423. doi: 10.3760/cma.j.issn.1671-8925.2018.04.019
[3]	Wang B N,Wu C B,Chen Z M,et al. DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress[J]. Acta Pharmacologica Sinica,2021,42(3):347-360. doi: 10.1038/s41401-020-00583-3
[4]	王小晗,郝新彬,张立军. 丁苯酞在脑小血管病患者中的疗效观察及对Aβ、T淋巴细胞百分比的影响研究[J]. 湖南师范大学学报(医学版),2020,17(6):139-142.
[5]	中华医学会老年医学分会老年神经病学组,脑小血管病认知功能障碍诊疗指南中国撰写专家组. 脑小血管病相关认知功能障碍中国诊疗指南(2019)[J]. 中华老年医学杂志,2019,38(4):345-354.
[6]	Cummings,Jeffrey L. Mini-mental state examination[J]. JAMA: Journal of the American Medical Association,1993,269(18):2420. doi: 10.1001/jama.1993.03500180112046
[7]	Kwah L K,Diong J. National institutes of health stroke scale (NIHSS)[J]. J Physiother,2014,60(1):61. doi: 10.1016/j.jphys.2013.12.012
[8]	Collin C,Wade D T,Davies S,et al. The barthel ADL index: A reliability study[J]. Int Disabil Stud,1988,10(2):61-3. doi: 10.3109/09638288809164103
[9]	杨萍,邢凤梅,张小丽. 老年脑卒中患者认知障碍的临床特征及影响因素[J]. 中国老年学杂志,2011,31(17):3217-3219.
[10]	H Wanting,C Liezhen,D Ling,et al. Dl-3-n-butylphthalide induced anaphylactic shock:A case report[J]. European Journal of Hospital Pharmacy:Science and Practice,2023,30(5):e23. doi: 10.1136/ejhpharm-2021-003124
[11]	马琳. 脑卒中后认知障碍诊治现状[J]. 中华老年心脑血管病杂志,2020,22(4):337-339.
[12]	刘婷婷. 丁苯肽联合吡拉西坦治疗脑卒中后认知功能障碍疗效及对血清同型半胱氨酸、胱抑素C水平影响[J]. 临床军医杂志,2019,47(4):377-378,380.
[13]	吴丽娟,黄文娟. 丁苯酞治疗缺血性脑卒中患者的临床研究[J]. 中国临床药理学杂志,2020,36(21):3418-3421.
[14]	张晓璇,朱江,李佳佳,等. 丁苯酞对缺血性脑卒中大鼠脑组织NF-κBp65、IL-6、TNF-α表达的影响[J]. 中国免疫学杂志,2019,35(15):1825-1828,1834.
[15]	邱珂,邓淑文,刘慧,等. 丁苯酞对SD大鼠脑出血后血脑屏障的影响及其机制[J]. 中南大学学报(医学版),2019,44(12):1321-1329.
[16]	邬刚,战丽萍,安明顺,等. 脑梗死急性期使用丁苯酞注射液对患者脑血流灌注和认知功能的影响[J]. 中国卒中杂志,2018,13(9):51-56.
[17]	代晓燕. 丁苯酞联合多奈哌齐治疗脑小血管病认知功能下降的疗效分析[J]. 基层医学论坛,2021,25(11):1556-1558.
[18]	李娜,贾晓静,司景荣. 丁苯酞联合养血清脑颗粒对脑小血管病认知障碍的疗效[J]. 北华大学学报(自然科学版),2020,21(3):362-365.
[19]	Wang Xinghua,Luan Xinchi,Yang Zhigang. The effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy[J]. Medicine,2023,102(34):e34616.
[20]	Yang Dan,Zhang Mi,Wang Xiaoyan,et al. Clinical efficacy and short-term prognosis of butylphthalide and sodium chloride injection compared to edaravone in the treatment of patients with acute stroke[J]. Alternative Therapies in Health and Medicine,2023,29(7):370-375.

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